Subarachnoid Enhancement Secondary to Subarachnoid Hemorrhage with Special Reference to the Clinical Significance and Pathogenesis

Neurosurgery ◽  
1982 ◽  
Vol 11 (3) ◽  
pp. 367-371 ◽  
Author(s):  
Yoshifumi Hirata ◽  
Yasuhiko Matsukado ◽  
Akinobu Fukumura
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Intracranial Aneurysm ◽  
Cerebral Infarction ◽  
Early Stage ◽  
Diffuse Type ◽  
Positive Group ◽  
Computed Tomographic ◽  
Contrast Enhanced ◽  
Ruptured Intracranial Aneurysm ◽  
Acute Subarachnoid Hemorrhage

Abstract Contrast-enhanced computed tomographic scans of 30 patients with acute subarachnoid hemorrhage due to ruptured intracranial aneurysm were analyzed in relation to subarachnoid enhancement and clinical features. In 15 cases, subarachnoid enhancement was noted either early or late during the clinical progress of subarachnoid hemorrhage. In the positive group, hydrocephalus and cerebral infarction due to vasospasm frequently accompanied enhancement during the early stage of subarachnoid hemorrhage. The diffuse type of subarachnoid enhancement was most valuable for predicting cerebral infarction due to vasospasm. The authors review the literature on the pathogenesis of subarachnoid enhancement.

scholarly journals Identification of upregulated NF-κB inhibitor alpha and IRAK3 targeting lncRNA following intracranial aneurysm rupture-induced subarachnoid hemorrhage

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wei Leng ◽  
Dan Fan ◽  
Zhong Ren ◽  
Qiaoying Li
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Intracranial Aneurysm ◽  
Signaling Pathway ◽  
Aneurysm Rupture ◽  
Cytokine Receptor ◽  
Gene Set Enrichment Analysis ◽  
Receptor Interaction ◽  
Regulatory Pathways ◽  
Ruptured Intracranial Aneurysm ◽  
Neurotrophin Signaling

Abstract Background This study was performed to identify genes and lncRNAs involved in the pathogenesis of subarachnoid hemorrhage (SAH) from ruptured intracranial aneurysm (RIA). Methods Microarray GSE36791 was downloaded from Gene Expression Omnibus (GEO) database followed by the identification of significantly different expressed RNAs (DERs, including lncRNA and mRNA) between patients with SAH and healthy individuals. Then, the functional analyses of DEmRNAs were conducted and weighted gene co-expression network analysis (WGCNA) was also performed to extract the modules associated with SAH. Following, the lncRNA-mRNA co-expression network was constructed and the gene set enrichment analysis (GSEA) was performed to screen key RNA biomarkers involved in the pathogenesis of SAH from RIA. We also verified the results in a bigger dataset GSE7337. Results Totally, 561 DERs, including 25 DElncRNAs and 536 DEmRNAs, were identified. Functional analysis revealed that the DEmRNAs were mainly associated with immune response-associated GO-BP terms and KEGG pathways. Moreover, there were 6 modules significantly positive-correlated with SAH. The lncRNA-mRNA co-expression network contained 2 lncRNAs (LINC00265 and LINC00937) and 169 mRNAs. The GSEA analysis showed that these two lncRNAs were associated with three pathways (cytokine-cytokine receptor interaction, neurotrophin signaling pathway, and apoptosis). Additionally, IRAK3 and NFKBIA involved in the neurotrophin signaling pathway and apoptosis while IL1R2, IL18RAP and IL18R1 was associated with cytokine-cytokine receptor interaction pathway. The expression levels of these genes have the same trend in GSE36791 and GSE7337. Conclusion LINC00265 and LINC00937 may be implicated with the pathogenesis of SAH from RIA. They were involved in three important regulatory pathways. 5 mRNAs played important roles in the three pathways.

Cerebral infarction associated with acute subarachnoid hemorrhage

2007 ◽  
Vol 7 (1) ◽  
pp. 10-17 ◽  
Author(s):  
J. Michael Schmidt ◽  
Fred Rincon ◽  
Andres Fernandez ◽  
Charles Resor ◽  
Robert G. Kowalski ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Infarction ◽  
Acute Subarachnoid Hemorrhage

Social Outcome Related to Cognitive Performance and Computed Tomographic Findings after Surgery for a Ruptured Intracranial Aneurysm

Neurosurgery ◽  
1990 ◽  
Vol 26 (4) ◽  
pp. 579-585 ◽  
Author(s):  
J. Vilkki ◽  
P. Holst ◽  
J. öhman ◽  
A. Servo ◽  
O. Heiskanen
Keyword(s):  
Intracranial Aneurysm ◽  
Social Relations ◽  
Cognitive Deficits ◽  
Poor Performance ◽  
Memory Deficits ◽  
Cognitive Tests ◽  
Depression And Anxiety ◽  
Computed Tomographic ◽  
Ruptured Intracranial Aneurysm ◽  
Diffuse Brain

Abstract A series of 83 patients was examined with a battery of cognitive tests, a clinical interview, and computed tomography 1 year after surgery for a ruptured intracranial aneurysm. Disability on the Glasgow Outcome Scale (33%), failure to return to work (25%), impaired social relations (25%), and subjective or clinical mental impairment (56%) were found to be related to each other and to poor performance on cognitive tests, especially to verbal impairments in patients with left lateral infarctions and to memory deficits and cognitive inflexibility in patients with frontal medial infarctions. Furthermore, cognitive deficits and poor outcome were associated with diffuse brain damage. Depression and anxiety were unrelated to test performances, but were frequently reported by patients with right lateral infarctions.

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