On the relationship between ruptured intracranial aneurysm and cerebral infarction

Abstract Contrast-enhanced computed tomographic scans of 30 patients with acute subarachnoid hemorrhage due to ruptured intracranial aneurysm were analyzed in relation to subarachnoid enhancement and clinical features. In 15 cases, subarachnoid enhancement was noted either early or late during the clinical progress of subarachnoid hemorrhage. In the positive group, hydrocephalus and cerebral infarction due to vasospasm frequently accompanied enhancement during the early stage of subarachnoid hemorrhage. The diffuse type of subarachnoid enhancement was most valuable for predicting cerebral infarction due to vasospasm. The authors review the literature on the pathogenesis of subarachnoid enhancement.

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Ruptured Intracranial Aneurysm Presenting as Cerebral Infarction in a Young Child

Pediatric Neurosurgery ◽

10.1159/000120553 ◽

1990 ◽

Vol 16 (6) ◽

pp. 326-330 ◽

Cited By ~ 2

Author(s):

A.M. Rojiani ◽

K.J. Poskitt ◽

D.D. Cochrane ◽

A.J. Macnab ◽

M.G. Norman

Keyword(s):

Young Child ◽

Intracranial Aneurysm ◽

Cerebral Infarction ◽

Ruptured Intracranial Aneurysm

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Lower Body Temperature Independently Predicts Delayed Cerebral Infarction in the Elderly With Ruptured Intracranial Aneurysm

Frontiers in Neurology ◽

10.3389/fneur.2021.763471 ◽

2022 ◽

Vol 12 ◽

Author(s):

Hui Lin ◽

Haojie Wang ◽

Yawen Xu ◽

Zhangya Lin ◽

Dezhi Kang ◽

...

Keyword(s):

Body Temperature ◽

Intracranial Aneurysm ◽

Elderly Patients ◽

Cerebral Infarction ◽

Roc Curve ◽

Adverse Outcomes ◽

Lower Body ◽

Lower Body Temperature ◽

Specificity And Sensitivity ◽

Ruptured Intracranial Aneurysm

Purpose: To assess the correlation between admission body temperature and delayed cerebral infarction in elderly patients with ruptured intracranial aneurysm (IA).Methods: Patients with ruptured IA diagnosed between 2012 and 2020 were retrospectively analyzed. Patients were divided into a non-infarction and an infarction group based on the presence of cerebral infarction after treatment. The demographic and clinical information of the patients was gathered. Outcomes at the 3-month follow-up were assessed using the modified Rankin Scale. Correlation between admission body temperature and cerebral infarction was assessed using Spearman's rank correlation coefficient. A receiver operating characteristic (ROC) curve was used to assess the specificity and sensitivity of admission body temperature to predict cerebral infarction.Results: A total of 426 patients (142 men and 284 women) with ruptured IA were enrolled. Elderly patients with cerebral infarction (12.4%) had a lower body temperature at admission (p < 0.001), higher prevalence of hypertension and diabetes (p = 0.051 and p = 0.092, respectively), and higher rate of poor outcomes (p < 0.001). Admission body temperature was independently associated with cerebral infarction (odds ratio [OR] = 5.469, p < 0.001); however, hypertension (OR = 0.542, p = 0.056), diabetes (OR = 0.750, p = 0.465), and aneurysm size (OR = 0.959, p = 0.060) showed no association. An inverse correlation between admission body temperature and the incidence of cerebral infarction was observed (Spearman's r =−0.195, p < 0.001). An admission body temperature of 36.6°C was able to distinguish infarction and non-infarction patients. The area under the ROC curve was 0.669 (specificity, 64.15%; sensitivity, 81.50%; p < 0.001).Conclusions: Lower body temperature at admission (≤36.6°C) is an independent predictor of delayed cerebral infarction in elderly patients who have undergone treatment for ruptured IA. Therefore, it could be a risk factor for adverse outcomes of IA.

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Identification of upregulated NF-κB inhibitor alpha and IRAK3 targeting lncRNA following intracranial aneurysm rupture-induced subarachnoid hemorrhage

BMC Neurology ◽

10.1186/s12883-021-02156-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Wei Leng ◽

Dan Fan ◽

Zhong Ren ◽

Qiaoying Li

Keyword(s):

Subarachnoid Hemorrhage ◽

Intracranial Aneurysm ◽

Signaling Pathway ◽

Aneurysm Rupture ◽

Cytokine Receptor ◽

Gene Set Enrichment Analysis ◽

Receptor Interaction ◽

Regulatory Pathways ◽

Ruptured Intracranial Aneurysm ◽

Neurotrophin Signaling

Abstract Background This study was performed to identify genes and lncRNAs involved in the pathogenesis of subarachnoid hemorrhage (SAH) from ruptured intracranial aneurysm (RIA). Methods Microarray GSE36791 was downloaded from Gene Expression Omnibus (GEO) database followed by the identification of significantly different expressed RNAs (DERs, including lncRNA and mRNA) between patients with SAH and healthy individuals. Then, the functional analyses of DEmRNAs were conducted and weighted gene co-expression network analysis (WGCNA) was also performed to extract the modules associated with SAH. Following, the lncRNA-mRNA co-expression network was constructed and the gene set enrichment analysis (GSEA) was performed to screen key RNA biomarkers involved in the pathogenesis of SAH from RIA. We also verified the results in a bigger dataset GSE7337. Results Totally, 561 DERs, including 25 DElncRNAs and 536 DEmRNAs, were identified. Functional analysis revealed that the DEmRNAs were mainly associated with immune response-associated GO-BP terms and KEGG pathways. Moreover, there were 6 modules significantly positive-correlated with SAH. The lncRNA-mRNA co-expression network contained 2 lncRNAs (LINC00265 and LINC00937) and 169 mRNAs. The GSEA analysis showed that these two lncRNAs were associated with three pathways (cytokine-cytokine receptor interaction, neurotrophin signaling pathway, and apoptosis). Additionally, IRAK3 and NFKBIA involved in the neurotrophin signaling pathway and apoptosis while IL1R2, IL18RAP and IL18R1 was associated with cytokine-cytokine receptor interaction pathway. The expression levels of these genes have the same trend in GSE36791 and GSE7337. Conclusion LINC00265 and LINC00937 may be implicated with the pathogenesis of SAH from RIA. They were involved in three important regulatory pathways. 5 mRNAs played important roles in the three pathways.

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Clinical Characteristics of Ruptured Intracranial Aneurysm in Patients with Multiple Intracranial Aneurysms

World Neurosurgery ◽

10.1016/j.wneu.2021.01.072 ◽

2021 ◽

Author(s):

Hiroki Sato ◽

Tomoya Kamide ◽

Yuichiro Kikkawa ◽

Tatsuki Kimura ◽

Seiji Kuribara ◽

...

Keyword(s):

Intracranial Aneurysm ◽

Intracranial Aneurysms ◽

Clinical Characteristics ◽

Multiple Intracranial Aneurysms ◽

Ruptured Intracranial Aneurysm

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The safety of intraoperative lumbar subarachnoid drainage for acutely ruptured intracranial aneurysm: Technical note

Surgical Neurology ◽

10.1016/s0090-3019(96)00472-7 ◽

1997 ◽

Vol 48 (4) ◽

pp. 338-344 ◽

Cited By ~ 21

Author(s):

E.Sander Connolly ◽

Abraham A. Kader ◽

Vincent I. Frazzini ◽

Christopher J. Winfree ◽

Robert A. Solomon

Keyword(s):

Intracranial Aneurysm ◽

Technical Note ◽

Ruptured Intracranial Aneurysm

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Abstract WMP30: Circulating MicroRNAs as Potential Novel Diagnostic Biomarkers for Ruptured Intracranial Aneurysm

Stroke ◽

10.1161/str.48.suppl_1.wmp30 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Zhang Xin ◽

Liu L Ping

Keyword(s):

Intracranial Aneurysm ◽

Target Genes ◽

Bioinformatic Analysis ◽

Aneurysm Rupture ◽

Pathological Process ◽

Differentially Expressed ◽

Diagnostic Biomarkers ◽

Ruptured Intracranial Aneurysm ◽

Novel Biomarkers ◽

Aneurysm Development

Background and Objective: MicroRNAs have been shown to regulate in several pathological process of intracranial aneurysms. The study aimed to estimate whether miRNAs have the potential to become novel biomarkers for intracranial aneurysm rupture. Materials and methods Forty-five ruptured intracranial aneurysm patients were enrolled according to the inclusion criteria, meanwhile thirty-five healthy individuals were recruited in this study. Differentially expressed plasma miRNA profiles were screened in five pairs of patients and controls in microarray study. Then validation was performed in the rest of the objects using quantitative real-time PCR assays. Results: Fourteen significantly changed miRNAs were screened out from patients with aneurysms compared with healthy controls. More than three thousand target genes related to these disregulated miRNAs were found and bioinformatic analysis revealed that these miRNA were involved in intracranial aneurysm development and rupture. Ultimately four miRNAs from screening profile and one supplementary miRNA were demonstrated to be significantly altered. Conclusion: We demonstrated that several miRNAs were differentially expressed among ruptured aneurysm patients and healthy participants, and plasma miRNAs may be novel diagnostic biomarkers in intracranial aneurysm rupture.

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