Hemoglobinemia and Renal Failure from an Intracerebral Hematoma Simulating a Vein of Galen Aneurysm

Neurosurgery ◽  
1987 ◽  
Vol 21 (1) ◽  
pp. 107-109
Author(s):  
George I. Chovanes ◽  
Raymond C. Truex
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Intracerebral Hematoma ◽  
Vein Of Galen ◽  
Free Hemoglobin ◽  
Intracranial Hematoma ◽  
Vein Of Galen Aneurysm ◽  
Etiological Role ◽  
The Relationship

Abstract A case of an intracranial hematoma in a neonate causing the release of free hemoglobin into the plasma is presented. No previous such case has been described. The relationship between hemoglobinemia and the occurrence of acute renal failure in this neonate is discussed, with comments on the possible etiological role of the hemoglobinemia. (Neurosurgery 21: 107-109, 1987)

scholarly journals Evaluating role of oxidative stress in determining the pathogenesis of falciparum malaria induced acute renal failure

2004 ◽  
Vol 19 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Rachita Nanda ◽  
Pramila K. Mishra ◽  
U. K. Das ◽  
S. B. Rout ◽  
P. C. Mohapatra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Falciparum Malaria

Role of N-Acetylcysteine in the Prevention of Radiocontrast-Induced Nephropathy

2002 ◽  
Vol 36 (9) ◽  
pp. 1466-1470 ◽  
Author(s):  
Donald F Brophy
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Large Scale ◽  
English Language ◽  
Small Animal ◽  
Human Studies ◽  
Animal Trials ◽  
Study Selection ◽  
Risk Patients

OBJECTIVE: To examine the role of N-acetylcysteine (NAC) in the prevention of radiocontrast—induced nephropathy (RIN). DATA SOURCES: A literature search of MEDLINE (1966–December 2001) was performed using the following search terms: N-acetylcysteine, nephropathy, acute renal failure, and radiocontrast. STUDY SELECTION: Pertinent English-language animal and human studies were reviewed. DATA SYNTHESIS: Few small animal trials have demonstrated that NAC significantly prevents the development or reduces the severity of acute renal failure. Two human studies demonstrated NAC significantly reduces the occurrence of RIN. CONCLUSIONS: NAC may reduce the occurrence of RIN in high-risk patients. Further large-scale studies are needed to corroborate findings from earlier trials.

The Prevention of Acute Renal Failure in the Rat by Long-Term Saline Loading: A Possible Role of the Renin-Angiotensin Axis

1969 ◽  
Vol 131 (2) ◽  
pp. 610-614 ◽  
Author(s):  
F. D. McDonald ◽  
G. Thiel ◽  
D. R. Wilson ◽  
G. F. DiBona ◽  
D. E. Oken
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Renin Angiotensin ◽  
Saline Loading

scholarly journals Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge

2009 ◽  
Vol 296 (1) ◽  
pp. F135-F144 ◽  
Author(s):  
Renee E. Yura ◽  
S. Gaylen Bradley ◽  
Ganesan Ramesh ◽  
W. Brian Reeves ◽  
Judith S. Bond
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Urinary Tract ◽  
Nitrogen Levels ◽  
Lps Challenge ◽  
Lower Blood ◽  
Tnf Α ◽  
Meprin Metalloproteases ◽  
Membrane Bound

Meprin metalloproteases, composed of α and/or β subunits, consist of membrane-bound and secreted forms that are abundantly expressed in proximal tubules of the kidney as well as secreted into the urinary tract. Previous studies indicated that meprin metalloproteases play a role in pathological conditions such as ischemic acute renal failure and urinary tract infection. The aim of this work was to examine the role of meprins in endotoxemic acute renal failure using meprin α knockout (αKO), meprin β knockout (βKO), and wild-type (WT) mice. Differences among the responses of the genotypes were observed as early as 1 h after challenge with 2.5 mg/kg ip Escherichia coli LPS, establishing roles for meprins in the endotoxemic response. Meprin αKO mice displayed lower blood urea nitrogen levels and decreased nitric oxide levels, indicative of a decreased systemic response to LPS compared with WT and meprin βKO mice. Serum cytokine profiles showed lower levels of IL-1β and TNF–α in the meprin αKO mice within 3 h after LPS challenge and confirmed a role for meprins in the early phases of the host response. Meprin αKO mice were also hyporesponsive to LPS administered to the bladder, exhibiting significantly less bladder edema, leukocyte infiltration, and bladder permeability than WT mice. These data indicate that meprin A contributes to the renal and urogenital pathogenesis of endotoxicity.

The Pathogenesis of Experimental Acute Renal Failure: The Role of Membrane Dysfunction

1977 ◽  
pp. 73-115 ◽  
Author(s):  
Walter Flamenbaum ◽  
John H. Schwartz ◽  
Robert J. Hamburger ◽  
James S. Kaufman
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure
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