Two-year Follow-up Study of a Patient with Parkinson's Disease and Severe Motor Fluctuations Treated by Co-grafts of Adrenal Medulla and Peripheral Nerve into Bilateral Caudate Nuclei

Neurosurgery ◽  
1995 ◽  
Vol 37 (3) ◽  
pp. 515-519 ◽  
Author(s):  
Isao Date ◽  
Shoji Asari ◽  
Takashi Ohmoto
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Peripheral Nerve ◽  
Adrenal Medulla ◽  
Motor Fluctuations ◽  
Caudate Nuclei ◽  
Follow Up Study ◽  
Severe Motor

Effect of Stereotaxic Intrastriatal Cografts of Autologous Adrenal Medulla and Peripheral Nerve in Parkinson's Disease: Two-Year Follow-up Study

1997 ◽  
Vol 147 (2) ◽  
pp. 510-517 ◽  
Author(s):  
Ray L. Watts ◽  
Thyagarajan Subramanian ◽  
Alan Freeman ◽  
Christopher G. Goetz ◽  
Richard D. Penn ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Peripheral Nerve ◽  
Adrenal Medulla ◽  
Follow Up Study

Chromaffin cell survival and host dopaminergic fiber recovery in a patient with Parkinson's disease treated by cografts of adrenal medulla and pretransected peripheral nerve

1996 ◽  
Vol 84 (4) ◽  
pp. 685-689 ◽  
Author(s):  
Isao Date ◽  
Takashi Imaoka ◽  
Yasuyuki Miyoshi ◽  
Takeshi Ono ◽  
Shoji Asari ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Peripheral Nerve ◽  
Adrenal Medulla ◽  
Chromaffin Cells ◽  
Chromaffin Cell ◽  
Caudate Nuclei ◽  
Modest Improvement ◽  
Content Type ◽  
Grafting Procedure

✓ A 55-year-old woman with severe Parkinson's disease was treated by cografting adrenal medulla with pretransected peripheral nerve into the bilateral caudate nuclei. The patient showed modest improvement of her akinesia; this effect persisted for 1 year after transplantation, when she suddenly died from upper gastrointestinal bleeding unrelated to the grafting procedure. At autopsy, a large number of tyrosine hydroxylase—immunoreactive chromaffin cells were observed within the caudate graft sites and a dense network of host dopaminergic fibers was visualized. This autopsy finding is very important for the field of experimental and clinical chromaffin cell grafting because it is the first evidence that cografts using pretransected peripheral nerve might enhance the survival of chromaffin cells and the recovery of host dopaminergic fibers in humans suffering from Parkinson's disease.

scholarly journals Autologous Transplantation of Adrenal Medulla Into the Caudate Nucleus: A Four Year Follow Up Study

1992 ◽  
Vol 3 (4) ◽  
pp. 290-291
Author(s):  
E. Garcia-Flores ◽  
A. Martinez-Campos ◽  
R. Farias
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Caudate Nucleus ◽  
Effective Treatment ◽  
Adrenal Medulla ◽  
Autologous Transplantation ◽  
Morbidity And Mortality ◽  
Follow Up Study

The objective of this study was to determine whether the associated morbidity and mortality of adrenal medulla autologous transplantation into the striatum (open transcortical procedure) justifies this as a safe and effective treatment for Parkinson's Disease (PD).

Migraine is related to an increased risk of Parkinson’s disease: A population-based, propensity score-matched, longitudinal follow-up study

Cephalalgia ◽  
2016 ◽  
Vol 36 (14) ◽  
pp. 1316-1323 ◽  
Author(s):  
Hsin-I Wang ◽  
Yu-Chun Ho ◽  
Ya-Ping Huang ◽  
Shin-Liang Pan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Survival Rate ◽  
Propensity Score ◽  
Population Based ◽  
Free Survival ◽  
Follow Up Study ◽  
Increased Risk ◽  
Migraine Group

Background The association between migraine and Parkinson’s disease (PD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether migraineurs are at a higher risk of developing PD. Methods A total of 41,019 subjects aged between 40 and 90 years with at least two ambulatory visits with a diagnosis of migraine in 2001 were enrolled in the migraine group. A logistic regression model that included age, sex, pre-existing comorbidities and socioeconomic status as covariates was used to compute the propensity score. The non-migraine group consisted of 41,019 propensity score-matched, randomly sampled subjects without migraine. The PD-free survival rate were estimated using the Kaplan–Meier method. Stratified Cox proportional hazard regression was used to estimate the effect of migraine on the risk of developing PD. Results During follow-up, 148 subjects in the migraine group and 101 in the non-migraine group developed PD. Compared to the non-migraine group, the hazard ratio of PD for the migraine group was 1.64 (95% confidence interval: 1.25–2.14, p = 0.0004). The PD-free survival rate for the migraine group was significantly lower than that for the non-migraine group ( p = 0.0041). Conclusions This study showed an increased risk of developing PD in patients with migraine.

Prediction of Parkinson’s disease subsequent to severe depression: a ten-year follow-up study

2014 ◽  
Vol 122 (6) ◽  
pp. 789-797 ◽  
Author(s):  
Uwe Walter ◽  
Robert Heilmann ◽  
Lara Kaulitz ◽  
Tino Just ◽  
Bernd Joachim Krause ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Severe Depression ◽  
Follow Up Study
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