The activity of hair follicles in parabiotic rats

Development ◽  
1964 ◽  
Vol 12 (3) ◽  
pp. 425-438
Author(s):  
F. J. Ebling ◽  
G. R. Hervey
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Hair Follicles ◽  
The Other ◽  
Complete Cycle ◽  
Other Hand ◽  
Different Ages ◽  
The Dead ◽  
Graft Skin ◽  
Follicular Activity

Hair growth in the rat occurs in a series of waves, which start ventrally and pass over the flanks to the back (Dry, 1926; Butcher, 1934; Johnson, 1958a). The activity of the hair follicle is cyclic; when the hair has been fully formed there is a period of quiescence during which the dead hair is retained as a ‘club’. The duration of the complete cycle varies with site and age, ranging from 24 to about 100 days (Ebling & Johnson, 1964). When hair follicles are translocated, they continue to maintain the periodicity characteristic of their sites of origin (Ebling & Johnson, 1959). On the other hand, when skin is exchanged between rats of different ages and thus with their hair growth waves out of phase, follicular activity in the graft skin in some circumstances comes into line with the activity of the host (Ebling & Johnson, 1961).

scholarly journals Systemic Influence on Activity of Hair Follicles in Skin Homografts

Development ◽  
1961 ◽  
Vol 9 (2) ◽  
pp. 285-293
Author(s):  
F. J. Ebiling ◽  
Elizabeth Johnson
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Hair Follicles ◽  
Normal Waves ◽  
Systemic Control ◽  
The Dead ◽  
Two Stages ◽  
Follicular Activity

Activity of the hair follicle is cyclic, periods of hair-growth alternating with periods of quiescence during which the dead hair is retained as a ‘club’. In the rat, hair-growth occurs in a series of waves which start ventrally and pass over the flanks to the back (Dry, 1926; Butcher, 1934; Johnson, 1958a). The object of our work was to find out how far such activity is dependent upon factors within the follicle and how far it is subject to systemic control. When hair follicles are translocated, either by rotation of grafts in the mid-flank or by transposition of flaps in two stages, they continue to maintain the periodicity characteristic of their sites of origin (Ebling & Johnson, 1959). Vascularization of such follicles is always consequent upon follicular activity, even when this is out of phase with the normal waves of hair-growth on the adjacent body.

Gendering grief: The Strī Parvan of the Mahābhārata

2020 ◽  
Vol 7 (2) ◽  
pp. 109-120
Author(s):  
Kumkum Roy
Keyword(s):  
The Other ◽  
Small Section ◽  
Other Hand ◽  
The Dead

The article focuses on Śānti Parvan, a small section of the Mahābhārata, describing the scene after the cataclysmic war. It explores the convergences and divergences between masculine and feminine expressions of grief in response to bereavement, as described here. The former appears to be concerned with identities of the dead as kshatriyas and kings. The latter, on the other hand, focuses more centrally on the dead as kinsmen-related through both natal and marital ties, even as there are overlaps.

Tissue interactions in embryonic mouse tooth germs

Development ◽  
1970 ◽  
Vol 24 (1) ◽  
pp. 173-186
Author(s):  
Edward J. Kollar ◽  
Grace R. Baird
Keyword(s):  
Hair Follicles ◽  
The Other ◽  
Embryonic Mouse ◽  
Plantar Surface ◽  
Tissue Interactions ◽  
Other Hand ◽  
Dental Epithelium ◽  
Tooth Germs

The response of embryonic mouse dental epithelium and mesoderm to tissues of ectopic origin was examined. Isolated molar or incisor mesoderm was confronted with epithelium isolated from the plantar surface of the embryonic mouse foot plate or from the snout. Harmoniously structured teeth were formed from the foot epithelium and incisor or molar mesoderm. These data are interpreted as an unequivocal demonstration of the inductive role of the dental mesenchyme. Teeth were absent in confrontations of dental mesenchyme and snout epithelium. The presence of hair follicles in these explants is described and discussed with reference to other integumental epithelio-mesenchymal interactions. Dental epithelium forms keratinizing surface-like epithelium and invading bands of epithelium in association with foot mesoderm; definitive structures are not formed. On the other hand, when incisor or molar epithelium is associated with snout mesoderm, hair follicles are seen in addition to keratinizing surface-like epithelial configurations. The roles of the epithelial and mesenchymal tissues and the nature of epithelio-mesenchymal interactions in the developing mouse integument are discussed.

The effect of plucking hairs during different phases of the follicular cycle

Development ◽  
1964 ◽  
Vol 12 (3) ◽  
pp. 465-474
Author(s):  
Elizabeth Johnson ◽  
F. J. Ebling
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Hair Cycle ◽  
Active Growth ◽  
The Dead

Hair growth is intermittent; periods of activity when the follicle is producing the hair alternating with periods of rest when the dead hair is retained. In the rat, hair growth occurs in a series of waves which start ventrally and pass over the flanks to the back (Dry, 1926; Butcher, 1934; Johnson, 1958). It has long been known (Collins, 1918; David, 1934) that if hairs are pulled out of resting follicles activity is induced. To explain this phenomenon, Chase (1955) put forward the view that an inhibitor accumulates in the hair follicle during active growth and is dissipated during the resting stage. Plucking during the resting stage removes this inhibitor along with the club hair, so that activity recommences. Preliminary observations on rats with plucked follicles indicated that the response to plucking varied at different stages of the hair cycle. A detailed study seemed desirable, therefore, in order to test more closely than hitherto the validity of the inhibitor hypothesis.

Contribution to the Study of the Death-rate of Persons in Asylums

1879 ◽  
Vol 25 (109) ◽  
pp. 1-4
Author(s):  
Arthur Mitchell
Keyword(s):  
General Population ◽  
Death Rate ◽  
The Other ◽  
Other Hand ◽  
Different Ages ◽  
The Mean ◽  
General Community

In the population of Scotch Asylums, there are so few persons below the age of 10 years that, for practical purposes, it may be correctly said there are none. of the general community, on the other hand, 25·6 per cent. are persons below that age. It is clear, therefore, that the death-rate of the population of asylums cannot properly be compared with the death-rate of the general population. To make such a comparison it is necessary to deal only with the deaths occurring among the 74·4 per cent. of the general community who are above the age of 10 years. When this is done, it appears that the mean annual death-rate for the general population is 1·7 per cent. as compared with 8·3 per cent. for the population of asylums. These figures refer to the whole population of asylums, and to the whole of the general population above the age of 10 years; but in order to show the rates at which persons of different ages die in asylums, and the rates at which persons of corresponding ages die in the general community, the following table has been prepared. It is founded on 3,800 deaths occurring during the seven years, 1870–1876, in the Asylums of Scotland, which had a mean population of 6,421 during those years.

scholarly journals Molecular Pathways Involved in Promoting Activity of Timosaponin BII on Hair Growth in C57BL/6 Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Lei Xiao ◽  
Xia Zhang ◽  
Zhiyi Chen ◽  
Jianhua Li ◽  
Bing Li ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Immunohistochemical Analysis ◽  
Hair Follicles ◽  
Common Disease ◽  
Male Mice ◽  
High Concentration ◽  
Anagen Phase ◽  
Approved Drugs ◽  
Anemarrhena Asphodeloides

Hair loss is a common disease in dermatology, while the approved drugs may have unpredictable side effects. In this study, the effect of timosaponin BII extracted from Anemarrhena asphodeloides on hair growth of C57BL/6 mice was investigated by measuring the hair follicle morphology, hair growth length and area in C57BL/6 male mice, and the immunohistochemical analysis of β-catenin, Wnt3a, and Wnt10b in the dorsal skins of mice after topical application with minoxidil and timosaponin BII for 15 days. The decrease in skin brightness, the increase in the regrowing area of hair and hair follicles numbers, and the improvement of hair follicle morphology in the group applied with 0.5% timosaponin BII indicated an induction of the anagen phase in telogenic mice skin, which were comparative to the 2% minoxidil treatment. The immunohistochemical analysis detected an increase in the expression of β-catenin and Wnt10b, supporting the theory of the activation of the β-catenin/Wnt pathway was one of the pathways that are related to anagen phase induction. Anemarrhena asphodeloides is a herb commonly used for metabolic disorders in China. The present study is the first to show that the timosaponin BII, which is present at a high concentration in A. asphodeloides, promotes hair growth in C57BL/6 male mice. The results indicate that timosaponin BII may be a potential promoting agent for hair growth.

scholarly journals Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

2020 ◽  
Vol 6 (30) ◽  
pp. eaba1685 ◽  
Author(s):  
Shiqi Hu ◽  
Zhenhua Li ◽  
Halle Lutz ◽  
Ke Huang ◽  
Teng Su ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Hair Cycle ◽  
Paracrine Signaling ◽  
Hair Regrowth ◽  
Study Results ◽  
Anagen Phase ◽  
Hair Follicle Cycle

The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment. Because of the importance of paracrine signaling in this process, secretome and exosomes were isolated from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. Western blot and immunofluorescence imaging were used to demonstrate that DP spheroid–derived exosomes up-regulated β-catenin, promoting the development of hair follicles.

On the Etymology of ΤΡΑΓΩΙΔΙΑ

1912 ◽  
Vol 6 (1) ◽  
pp. 60-63 ◽  
Author(s):  
Louis H. Gray
Keyword(s):  
The Other ◽  
Greek Religion ◽  
Other Hand ◽  
Introductory Article ◽  
Religion And Ethics ◽  
The Dead ◽  
Griechische Mythologie

In the course of the preparation of the introductory article on ‘Drama’ for Hastings Encyclopaedia of Religion and Ethics, my attention was directed, not only to the problem of the origin of this type of drama, but also to the basal meaning of the Greek term . It need scarcely be said that the rise of tragedy is almost universally connected with the cult of Dionysos (for the most recent exponents of this theory see Miss Harrison, Prolegomena to the Study of Greek Religion, pp. 568 sqq., Cambridge, 1908; Gruppe, Griechische Mythologie und Religionsgeschichte, p. 1436, Munich, 1906; Farnell, Cults of the Greek States, v. 229 sqq., Oxford, 1909). On the other hand, the theory has been advanced by Crusius (Preussische Jahrbiicher, lxxiv. [1893], 394), Hirt (Indogermanen, pp. 477 sq., 727, Strassburg, 1905–07), and especially Ridgeway (Address before the Hellenic Society, May, 1904 [cf. Athenaeum, No. 3995, p. 660, and Maas in Wochenblatt für klassische Philologie, 1904, pp. 779–783]; and particularly in his Origin of Tragedy, Cambridge, 1910), that tragedy arose not from the Dionysos-cult, but from the desire to honour and appease the dead. It is to this latter theory that I strongly incline, and I feel that tragedy can be connected with the cult of Dionysos only through this deity's aspect of a chthonic god who gave release from the lower world and who was later identified with Attis, Adonis, and Osiris (cf. Harrison, chap. viii.; Farnell, chap, v.; Gruppe, pp. 1407–1440).

A Group of Plastic Vases

1938 ◽  
Vol 58 (2) ◽  
pp. 255-255
Author(s):  
Martin Robertson
Keyword(s):  
The Other ◽  
Other Hand ◽  
The Dead ◽  
Formed Part ◽  
Italian Origin ◽  
Made In

(JHS lviii, pp. 41 ff.). Fragments of two vases in the form of dead hares were found at Lindos (Blinkenberg, nos. 1934–5, pl. 85). These are certainly not Corinthian; Blinkenberg describes the fabric of 1934 as ‘ terre rouge fine ’ and that of 1935 as ‘ terre d'un chamois rougeâtre,’ and compares the Copenhagen vase, my no. 12. If these fragments belong to the group, the theory of an Italian origin cannot stand. On the other hand, I pointed out that the dead hare in Berlin (no. 13) has a vase-mouth differing in form and decoration from those of the rest of the group, and also lacks the distinctive colouring of the ears. It is therefore possible to detach it from the group, and suppose that vases of this type were made in two centres besides Corinth. The Lindos fragments lack ears and vase-mouth, and so cannot be definitely placed. If they go with the Berlin vase, the Italian origin of the rest of the group can still be supported. The Lindos head, however, looks in illustration more like those of the vases in Copenhagen and the Vatican (no. 11) than of that in Berlin, while the latter was found at Vulci, and so formed part of the balance of evidence for an Italian origin. The question remains open, but the probability is that the Lindos fragments belong, and so that the group was not made in Italy.

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