Control ofDrosophilaimaginal disc development byrotundandroughened eye: differentially expressed transcripts of the same gene encoding functionally distinct zinc finger proteins

Development ◽  
2002 ◽  
Vol 129 (5) ◽  
pp. 1273-1281 ◽  
Author(s):  
Susan E. St Pierre ◽  
Maximo I. Galindo ◽  
Juan P. Couso ◽  
Stefan Thor
Keyword(s):  
Notch Signaling ◽  
Differential Expression ◽  
Zinc Finger ◽  
Zinc Finger Proteins ◽  
Differentially Expressed ◽  
Zinc Finger Domain ◽  
Negative Effects ◽  
Gene Encoding ◽  
Zinc Finger Genes ◽  
Overlapping Domains

The Drosophila rotund gene is required in the wings, antenna, haltere, proboscis and legs. A member of the Rac family of GTPases, denoted the rotund racGAP gene, was previously identified in the rotund region. However, previous studies indicated that rotund racGAP was not responsible for the rotund phenotypes and that the rotund gene had yet to be identified. We have isolated the rotund gene and show that it is a member of the Krüppel family of zinc finger genes. The adjacent roughened eye locus specifically affects the eye and is genetically separable from rotund. However, roughened eye and rotund are tightly linked, and we have therefore also isolated the roughened eye transcript. Intriguingly, we show that roughened eye is part of the rotund gene but is represented by a different transcript. The rotund and roughened eye transcripts result from the utilization of two different promoters that direct expression in non-overlapping domains in the larval imaginal discs. The predicted Rotund and Roughened Eye proteins share the same C-terminal region, including the zinc finger domain, but differ in their N-terminal regions. Each cDNA can rescue only the corresponding mutation and show negative effects when expressed in each others domain of expression. These results indicate that in addition to the differential expression of rotund and roughened eye, their proteins have distinct activities. rotund and roughened eye act downstream of early patterning genes such as dachshund and appear to be involved in Notch signaling by regulating Delta, scabrous and Serrate.

scholarly journals Differential expression of CKS2 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Regulatory Subunit ◽  
Luminal A ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the CDC28 protein kinase regulatory subunit 2, CKS2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CKS2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. CKS2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CKS2 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. CKS2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of dCTP pyrophosphatase 1 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Tissue Analysis ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding dCTP pyrophosphatase 1, DCTPP1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DCTPP1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. DCTPP1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of DCTPP1 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer. DCTPP1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of TUFT1 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Luminal A ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the tuftelin 1, TUFT1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TUFT1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. TUFT1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TUFT1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal and luminal A subtype cancer. TUFT1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of KIF11 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Luminal A ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the kinesin family member 11, KIF11, when comparing primary tumors of the breast to the tissue of origin, the normal breast. KIF11 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. KIF11 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of KIF11 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. KIF11 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of teashirt zinc finger homeobox 2 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Zinc Finger ◽  
Survival Data ◽  
Molecular Subtype ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding teashirt zinc finger homeobox 2, TSHZ2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TSHZ2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. TSHZ2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TSHZ2 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. TSHZ2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals ERp29 is differentially expressed in the brains of patients with schizophrenia.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Frontal Cortex ◽  
Differential Expression ◽  
Schizoaffective Disorder ◽  
Psychotic Disorders ◽  
Auditory Hallucinations ◽  
Differentially Expressed ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Microarray Datasets ◽  
Cardinal Feature

Visual and auditory hallucinations are a cardinal feature of psychotic disorders (1). We mined published and public microarray datasets (2, 3) to discover differentially expressed genes in schizophrenia and schizoaffective disorder. We found significant differential expression of the gene encoding ERp29 in neurons of the dorsolateral pre-frontal cortex from patients with schizophrenia and schizoaffective disorder.

scholarly journals Differential expression of hematological and neurological expressed 1 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Luminal A ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the hematological and neurological expressed 1, HN1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. HN1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. HN1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of HN1 in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer. HN1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of NACC1 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Luminal B ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding nucleus accumbens associated 1, NACC1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. NACC1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. NACC1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of NACC1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal B subtype cancer. NACC1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

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