scholarly journals Faithful mRNA splicing depends on the Prp19 complex subunitfaint sausageand is required for tracheal branching morphogenesis inDrosophila

Development ◽  
2017 ◽  
Vol 144 (4) ◽  
pp. 657-663 ◽  
Author(s):  
Julia Sauerwald ◽  
Charlotte Soneson ◽  
Mark D. Robinson ◽  
Stefan Luschnig
Keyword(s):  
Branching Morphogenesis ◽  
Mrna Splicing ◽  
Tracheal Branching

scholarly journals Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture

Development ◽  
2008 ◽  
Vol 135 (12) ◽  
pp. 2055-2064 ◽  
Author(s):  
M. Affolter ◽  
E. Caussinus
Keyword(s):  
Branching Morphogenesis ◽  
Cell Behaviour ◽  
Tracheal Branching

scholarly journals Social interactions among epithelial cells during tracheal branching morphogenesis

Nature ◽  
2006 ◽  
Vol 441 (7094) ◽  
pp. 746-749 ◽  
Author(s):  
Amin S. Ghabrial ◽  
Mark A. Krasnow
Keyword(s):  
Epithelial Cells ◽  
Social Interactions ◽  
Branching Morphogenesis ◽  
Tracheal Branching

scholarly journals In Vivo Imaging Reveals Different Cellular Functions for FGF and Dpp Signaling in Tracheal Branching Morphogenesis

2002 ◽  
Vol 2 (5) ◽  
pp. 677-683 ◽  
Author(s):  
Carlos Ribeiro ◽  
Andreas Ebner ◽  
Markus Affolter
Keyword(s):  
In Vivo Imaging ◽  
Branching Morphogenesis ◽  
Cellular Functions ◽  
Tracheal Branching

Organization of transcription and pre-mRNA splicing within the mammalian cell nucleus

1995 ◽  
Vol 53 ◽  
pp. 768-769
Author(s):  
D.L. Spector ◽  
S. Huang ◽  
S. Kaurin
Keyword(s):  
Rna Polymerase Ii ◽  
Cell Nucleus ◽  
Functional Organization ◽  
Mrna Splicing ◽  
Splicing Factors ◽  
Interchromatin Granule Clusters ◽  
Interchromatin Granule ◽  
Nuclear Regions ◽  
Relationship Of ◽  
Perichromatin Fibrils

We have been interested in the organization of RNA polymerase II transcription and pre-mRNA splicing within the cell nucleus. Several models have been proposed for the functional organization of RNA within the eukaryotic nucleus and for the relationship of this organization to the distribution of pre-mRNA splicing factors. One model suggests that RNAs which must be spliced are capable of recruiting splicing factors to the sites of transcription from storage and/or reassembly sites. When one examines the organization of splicing factors in the nucleus in comparison to the sites of chromatin it is clear that splicing factors are not localized in coincidence with heterochromatin (Fig. 1). Instead, they are distributed in a speckled pattern which is composed of both perichromatin fibrils and interchromatin granule clusters. The perichromatin fibrils are distributed on the periphery of heterochromatin and on the periphery of interchromatin granule clusters as well as being diffusely distributed throughout the nucleoplasm. These nuclear regions have been previously shown to represent initial sites of incorporation of 3H-uridine.

Regulation of insulin receptor mRNA splicing in rat tissues. Effect of fasting, aging, and diabetes

Diabetes ◽  
1995 ◽  
Vol 44 (10) ◽  
pp. 1196-1201 ◽  
Author(s):  
H. Vidal ◽  
D. Auboeuf ◽  
M. Beylot ◽  
J. P. Riou
Keyword(s):  
Insulin Receptor ◽  
Mrna Splicing ◽  
Rat Tissues ◽  
Receptor Mrna

Lighting a path: genetic studies pinpoint neurodevelopmental mechanisms in autism and related disorders

2012 ◽  
Vol 14 (3) ◽  
pp. 239-252
Keyword(s):  
Molecular Mechanisms ◽  
Protein Localization ◽  
Regulation Of Gene Expression ◽  
Neuronal Cell ◽  
Mrna Splicing ◽  
Genetic Mutations ◽  
Scaffolding Proteins ◽  
Molecular Processes ◽  
Genetic Studies ◽  
Novel Treatments

In this review, we outline critical molecular processes that have been implicated by discovery of genetic mutations in autism. These mechanisms need to be mapped onto the neurodevelopment step(s) gone awry that may be associated with cause in autism. Molecular mechanisms include: (i) regulation of gene expression; (ii) pre-mRNA splicing; (iii) protein localization, translation, and turnover; (iv) synaptic transmission; (v) cell signaling; (vi) the functions of cytoskeletal and scaffolding proteins; and (vii) the function of neuronal cell adhesion molecules. While the molecular mechanisms appear broad, they may converge on only one of a few steps during neurodevelopment that perturbs the structure, function, and/or plasticity of neuronal circuitry. While there are many genetic mutations involved, novel treatments may need to target only one of few developmental mechanisms.

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