The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration

2010 ◽  
Vol 123 (24) ◽  
pp. e1-e1 ◽  
Author(s):  
R. L. Shaw ◽  
A. Kohlmaier ◽  
C. Polesello ◽  
C. Veelken ◽  
B. A. Edgar ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Hippo Pathway ◽  
Intestinal Stem Cell ◽  
Stem Cell Proliferation ◽  
The Hippo Pathway

scholarly journals The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration

Development ◽  
2010 ◽  
Vol 137 (24) ◽  
pp. 4147-4158 ◽  
Author(s):  
R. L. Shaw ◽  
A. Kohlmaier ◽  
C. Polesello ◽  
C. Veelken ◽  
B. A. Edgar ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Hippo Pathway ◽  
Intestinal Stem Cell ◽  
Stem Cell Proliferation ◽  
The Hippo Pathway

scholarly journals The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation

2012 ◽  
Vol 3 (4) ◽  
pp. 291-304 ◽  
Author(s):  
Huan Liu ◽  
Dandan Jiang ◽  
Fangtao Chi ◽  
Bin Zhao
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Hippo Pathway ◽  
Self Renewal ◽  
Stem Cell Proliferation ◽  
The Hippo Pathway

scholarly journals Mitochondria regulate intestinal stem cell proliferation and epithelial homeostasis through FOXO

2020 ◽  
Vol 31 (14) ◽  
pp. 1538-1549
Author(s):  
Fan Zhang ◽  
Mehdi Pirooznia ◽  
Hong Xu
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Transcription Factor ◽  
Stem Cell ◽  
Electron Transport Chain ◽  
Intestinal Stem Cell ◽  
Stem Cell Proliferation ◽  
Epithelial Homeostasis ◽  
Chain Complexes ◽  
Transport Chain

Deficiencies in electron transport chain complexes increase the activity of FOXO transcription factor in Drosophila midgut stem cells, which impairs stem cell proliferation and enterocyte specification.

Canonical Wnt Signals Promote Intestinal Stem Cell Proliferation in the Native Human Colonic Epithelium

2011 ◽  
Vol 140 (5) ◽  
pp. S-48-S-49
Author(s):  
Alyson Parris ◽  
Natalia Scobioala-laker ◽  
Amy Reynolds ◽  
Loren Bigwood ◽  
Esther M. Mitchell ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Intestinal Stem Cell ◽  
Colonic Epithelium ◽  
Stem Cell Proliferation ◽  
Canonical Wnt

scholarly journals A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors

2020 ◽  
Vol 13 (7) ◽  
pp. dmm044420 ◽  
Author(s):  
Anjali Bajpai ◽  
Taushif Ahmad Quazi ◽  
Hong-Wen Tang ◽  
Nishat Manzar ◽  
Virender Singh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hippo Pathway ◽  
Intestinal Stem Cell ◽  
Peptide Therapeutics ◽  
Small Molecule Drugs ◽  
Drosophila Model ◽  
Therapeutic Peptides ◽  
Oral Therapeutic ◽  
The Hippo Pathway

ABSTRACTPeptide therapeutics, unlike small-molecule drugs, display crucial advantages of target specificity and the ability to block large interacting interfaces, such as those of transcription factors. The transcription co-factor of the Hippo pathway, YAP/Yorkie (Yki), has been implicated in many cancers, and is dependent on its interaction with the DNA-binding TEAD/Sd proteins via a large Ω-loop. In addition, the mammalian vestigial-like (VGLL) proteins, specifically their TONDU domain, competitively inhibit YAP-TEAD interaction, resulting in arrest of tumor growth. Here, we show that overexpression of the TONDU peptide or its oral uptake leads to suppression of Yki-driven intestinal stem cell tumors in the adult Drosophila midgut. In addition, comparative proteomic analyses of peptide-treated and untreated tumors, together with chromatin immunoprecipitation analysis, reveal that integrin pathway members are part of the Yki-oncogenic network. Collectively, our findings establish Drosophila as a reliable in vivo platform to screen for cancer oral therapeutic peptides and reveal a tumor suppressive role for integrins in Yki-driven tumors.This article has an associated First Person interview with the first author of the paper.

scholarly journals Rac1 drives intestinal stem cell proliferation and regeneration

Cell Cycle ◽  
2013 ◽  
Vol 12 (18) ◽  
pp. 2973-2977 ◽  
Author(s):  
Kevin Myant ◽  
Alessandro Scopelliti ◽  
Sara Haque ◽  
Marcos Vidal ◽  
Owen Sansom ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Intestinal Stem Cell ◽  
Stem Cell Proliferation
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