The role of protein kinase C isoenzymes in the regulation of cell proliferation and differentiation

1992 ◽  
Vol 103 (4) ◽  
pp. 881-887 ◽  
Author(s):  
M. J. CLEMENS ◽  
I. TRAYNER ◽  
J. MENAYA
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Kinase C ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation

Protein kinase C: a target for anticancer drugs?

2003 ◽  
pp. 389-396 ◽  
Author(s):  
H J Mackay ◽  
C J Twelves
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Anticancer Therapy ◽  
Kinase C ◽  
Cell Proliferation And Differentiation ◽  
Selective Targeting ◽  
Proliferation And Differentiation ◽  
Tumour Cell Invasion ◽  
Suitable Target

Protein kinase C (PKC) is a family of serine/threonine kinases that is involved in the transduction of signals for cell proliferation and differentiation. The important role of PKC in processes relevant to neoplastic transformation, carcinogenesis and tumour cell invasion renders it a potentially suitable target for anticancer therapy. Furthermore, there is accumulating evidence that selective targeting of PKC may improve the therapeutic efficacy of established neoplastic agents and sensitise cells to ionising radiation. This article reviews the rationale for targeting PKC, focuses on its role in breast cancer and reviews the preclinical and clinical data available for the efficacy of PKC inhibition.

Protein Kinase C in Cell Proliferation and Differentiation

1988 ◽  
Vol 551 (1 Membrane in C) ◽  
pp. 369-371 ◽  
Author(s):  
SERGIO ADAMO ◽  
CLARA NERVI ◽  
ROBERTA CECI ◽  
LUCIANA DE ANGELIS ◽  
MARIO MOLINARO
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Kinase C ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation

Role of protein kinase C in induction of gene expression and inhibition of cell proliferation by interferon alpha

1992 ◽  
Vol 209 (3) ◽  
pp. 813-822 ◽  
Author(s):  
Robert I. JAMES ◽  
Juan MENAYA ◽  
Kati HUDSON ◽  
Vinod DEVALIA ◽  
Jonathan RYVES ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Interferon Alpha ◽  
Kinase C

scholarly journals Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C.

1991 ◽  
Vol 266 (10) ◽  
pp. 6188-6194
Author(s):  
D Boscoboinik ◽  
A Szewczyk ◽  
C Hensey ◽  
A Azzi
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Alpha Tocopherol ◽  
Kinase C
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