The Role of O6-Methylguanine in Human Cell Killing, Sister Chromatid Exchange Induction and Mutagenesis: A Review

1987 ◽  
Vol 1987 (Supplement 6) ◽  
pp. 333-353 ◽  
Author(s):  
R. S. DAY ◽  
M. A. BABICH ◽  
D. B. YAROSH ◽  
D. A. SCUDIERO
Keyword(s):  
Human Cell ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Cell Killing

The Role of O6-Alkylguanine in Cell Killing and Sister Chromatid Exchange Induced by Alkylating Agents

1989 ◽  
pp. 129-139 ◽  
Author(s):  
Angelo Abbondandolo ◽  
Gabriele Aquilina ◽  
Margherita Bignami ◽  
Stefania Bonatti ◽  
Roberto Cosani ◽  
...  
Keyword(s):  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Alkylating Agents ◽  
Cell Killing

Protective effects of selenium against sister chromatid exchange induced by AFG 1 in human lymphocytes in vitro

2010 ◽  
Vol 30 (6) ◽  
pp. 515-519
Author(s):  
Lokman Alpsoy ◽  
Elif Kotan ◽  
Abdulgani Tatar ◽  
Guleray Agar
Keyword(s):  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Human Lymphocytes ◽  
Protective Role ◽  
Blood Cultures ◽  
Protective Effects ◽  
Low Concentrations ◽  
High Concentrations

Aflatoxins have been shown to be hepatotoxic, carcinogenic, mutagenic and teratogenic to different species of animals. Besides, at low concentrations, Selenium (Se4+) is antimutagenic and anticarcinogenic while it is toxic, mutagenic and carcinogenic at high concentrations. In this study, we aimed to evaluate the effect of Se4+ against aflatoxin GAFG1 (AFG1) on blood cultures in relation to induction of sister chromatid exchange (SCE). The results showed that at 0.4 and 0.8 parts per million (ppm) concentration of AFG1, the frequency of SCE increased in cultured human lymphocytes. When different concentration of Se4+ (0.08 and 8 ppm) were added to AFG1, the frequencies of SCE decreased. Howewer, when 800 ppm concentration of Se4+ together with 0.08 ppm AFG1 were added to cell division inhibited in the cultures. Results suggested that Se4+ could effectively inhibit AFG1-induced SCE. Besides, the protective role of Se4+ against AFG1-induced SCE is probably related to its doses.

Production of sister-chromatid exchange by irradiation during the G1 stage: The probable role of 5-bromodeoxyuridine

1987 ◽  
Vol 190 (2) ◽  
pp. 149-152 ◽  
Author(s):  
N.V. Luchnik ◽  
N.A. Porjadkova ◽  
T.V. Kondrashova ◽  
A.S. Seilanov
Keyword(s):  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Probable Role

Baseline Sister Chromatid Exchange in Human Cell Lines with Different Levels of Poly(ADP-Ribose) Polymerase

1991 ◽  
Vol 127 (1) ◽  
pp. 107 ◽  
Author(s):  
Timothy J. Jorgensen ◽  
Jay C. Leonard ◽  
Peter J. Thraves ◽  
Anatoly Dritschilo
Keyword(s):  
Cell Lines ◽  
Human Cell ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Human Cell Lines ◽  
Different Levels

Role of metabolic activation in the sister chromatid exchange-inducing activity of ethyl carbamate (Urethane) and vinyl carbamate

1981 ◽  
Vol 89 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Irén Csukás ◽  
Erzsébet Gungl ◽  
Ferenc Antoni ◽  
Gábor Vida ◽  
Ferenc Solymosy
Keyword(s):  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Metabolic Activation ◽  
Ethyl Carbamate ◽  
Vinyl Carbamate

Role of GSTT1and GSTM1genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes

1995 ◽  
Vol 16 (6) ◽  
pp. 1261-1264 ◽  
Author(s):  
Hannu Norppa ◽  
Ari Hirvonen ◽  
Hilkka Ojajäventaus ◽  
Mart Uuskiila ◽  
Gunnar Tasa ◽  
...  
Keyword(s):  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Human Lymphocytes ◽  
Individual Sensitivity
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