A role for nitric oxide in the control of breathing in zebrafish (Danio rerio)

2015 ◽  
Vol 218 (23) ◽  
pp. 3746-3753 ◽  
Author(s):  
C. S. Porteus ◽  
J. Pollack ◽  
V. Tzaneva ◽  
R. W. M. Kwong ◽  
Y. Kumai ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Danio Rerio ◽  
Control Of Breathing

scholarly journals The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio)

2014 ◽  
Vol 592 (14) ◽  
pp. 3075-3088 ◽  
Author(s):  
Cosima S. Porteus ◽  
Sara J. Abdallah ◽  
Jacob Pollack ◽  
Yusuke Kumai ◽  
Raymond W. M. Kwong ◽  
...  
Keyword(s):  
Hydrogen Sulphide ◽  
Danio Rerio ◽  
Control Of Breathing

scholarly journals The Relationship between Estrogen and Nitric Oxide in the Prevention of Cardiac and Vascular Anomalies in the Developing Zebrafish (Danio Rerio)

2016 ◽  
Vol 6 (4) ◽  
pp. 51 ◽  
Author(s):  
Benjamin Sykes ◽  
Peter Van Steyn ◽  
Jonathan Vignali ◽  
John Winalski ◽  
Julie Lozier ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Danio Rerio ◽  
Vascular Anomalies ◽  
The Relationship

scholarly journals Role of endogenous carbon monoxide in the control of breathing in zebrafish (Danio rerio)

2016 ◽  
Vol 311 (6) ◽  
pp. R1262-R1270 ◽  
Author(s):  
Velislava Tzaneva ◽  
Steve F. Perry
Keyword(s):  
Carbon Monoxide ◽  
Danio Rerio ◽  
Larval Fish ◽  
Protoporphyrin Ix ◽  
Control Of Breathing ◽  
Zinc Protoporphyrin ◽  
Hypoxic Conditions ◽  
First Time

Carbon monoxide (CO) is a gaseous signaling molecule and is produced in vivo from the intracellular breakdown of heme via the heme oxygenase (HO) family of enzymes. In this study we investigated the role of the HO-1/CO system in the control of ventilation in zebrafish, Danio rerio. Immunohistochemistry revealed the presence of HO-1 in the chemoreceptive neuroepithelial cells (NECs) of larvae (4 days postfertilization) and adults, indicating the potential for endogenous CO production in the NECs. Hypoxia (20 min, water Po2 of 30 mmHg) caused a significant increase in HO-1 activity in whole larvae and in the gills of adult fish. Zebrafish with reduced HO-1 activity (via HO-1 knockdown in larvae or zinc protoporphyrin IX treatment in adults) exhibited increased ventilation frequency ( Vf) under normoxic but not hypoxic conditions. The addition of exogenous CO restored resting Vf in fish with diminished CO production, and in some cases (e.g., hypoxic sham larvae) CO modestly reduced Vf below resting levels. Larval fish were treated with phenylhydrazine (PHZ) to eliminate the potential confounding effects of CO-hemoglobin interactions that might influence ventilation. PHZ treatment did not cause changes in Vf of normoxic larvae, and the addition of CO to PHZ-exposed larvae resulted in a significant decrease in sham and HO-1-deficient fish under normoxic conditions. This study demonstrates for the first time that CO plays an inhibitory role in the control of breathing in larval and adult zebrafish.

Effect of N ω-nitro-l-arginine on ventilatory response to hypercapnia in anesthetized cats

1997 ◽  
Vol 82 (1) ◽  
pp. 292-297 ◽  
Author(s):  
Luc Teppema ◽  
Aad Berkenbosch ◽  
Cees Olievier
Keyword(s):  
Nitric Oxide ◽  
Time Delay ◽  
Inhibitory Action ◽  
Ventilatory Response ◽  
Control Of Breathing ◽  
Constant Time Delay ◽  
Central Component ◽  
End Tidal ◽  
The Brain ◽  
Respiratory Movements

Teppema, Luc, Aad Berkenbosch, and Cees Olievier Effect of N ω-nitro-l-arginine on ventilatory response to hypercapnia in anesthetized cats. J. Appl. Physiol. 82(1): 292–297, 1997.—The effect of intravenous administration of 40 mg/kg N ω-nitro-l-arginine (l-NNA), an inhibitor of the synthesis of nitric oxide (NO), on the ventilatory response to CO2 was studied in anesthetized cats. The ventilatory response to CO2 was assessed during normoxia by applying square-wave changes in end-tidal[Formula: see text] of ∼1 kPa. Each CO2 response was separated into a fast peripheral and slow central component characterized by a CO2 sensitivity (Spand Sc, respectively), time constant, time delay, and an offset (apneic threshold). l-NNA reduced Sp, Sc, and the apneic threshold significantly by ∼30%. However, the ratio Sp/Scwas not changed. It is argued that the reduction in Sp and Sc, Sp/Scremaining constant, may be due to a potent inhibitory action ofl-NNA on the brain stem respiratory-integrating centers and on the neuromechanical link between these centers and respiratory movements. It is concluded that NO plays an important role in the control of breathing.

scholarly journals The Roles of Estrogen, Nitric Oxide, and Dopamine in the Generation of Hyperkinetic Motor Behaviors in Embryonic Zebrafish (Danio rerio)

2018 ◽  
Author(s):  
Conor Snyder ◽  
Reid Wilkinson ◽  
Amber Woodard ◽  
Andrew Lewis ◽  
Dallas Wood ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Danio Rerio ◽  
Motor Behaviors

The role of nitric oxide in the neural control of breathing

2008 ◽  
Vol 164 (1-2) ◽  
pp. 143-150 ◽  
Author(s):  
Stephen R. Reeves ◽  
Narong Simakajornboon ◽  
David Gozal
Keyword(s):  
Nitric Oxide ◽  
Neural Control ◽  
Control Of Breathing ◽  
Neural Control Of Breathing
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