scholarly journals Adjuvant Radiotherapy in the Treatment of Invasive Intraductal Papillary Mucinous Neoplasm of the Pancreas: an Analysis of the Surveillance, Epidemiology, and End Results Registry

2011 ◽  
Vol 19 (4) ◽  
pp. 1316-1323 ◽  
Author(s):  
Mathias Worni ◽  
Igor Akushevich ◽  
Beat Gloor ◽  
John Scarborough ◽  
Junzo P. Chino ◽  
...  
Keyword(s):  
Intraductal Papillary Mucinous Neoplasm ◽  
Adjuvant Radiotherapy ◽  
Mucinous Neoplasm ◽  
End Results

scholarly journals Prognostic Analysis of Different Metastatic Patterns in Invasive Intraductal Papillary Mucinous Neoplasm: A Surveillance, Epidemiology, and End Results Database Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Chen Zhou ◽  
Zhiqiang Liu ◽  
Yingke Zhou ◽  
Dianyun Ren ◽  
Kun Liu ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Survival Rates ◽  
Survival Outcomes ◽  
Mucinous Neoplasm ◽  
Isolated Lung ◽  
Multiple Metastases ◽  
Metastatic Patterns ◽  
Isolated Liver ◽  
End Results

Objective. To evaluate the impacts of different metastatic patterns on the prognosis of patients with invasive intraductal papillary mucinous neoplasm (IPMN). Materials and Methods. All patients who were diagnosed with invasive IPMN in the Surveillance, Epidemiology, and End Results SEER database (2010–2015) were included in this study. They were grouped according to different metastatic patterns. Kaplan–Meier analysis and log-rank test were used for the comparison of their survival rates. The hazard ratio (HR) with 95% confidence interval (CI) was analyzed using the Cox proportional-hazards model. Results. A total of 2264 cases were included in this study. The most common metastatic site was the liver. The patients with the nonorgan metastasis demonstrated the best survival outcomes, while those with multiple metastases showed the worst survival outcomes. As compared to the patients with isolated liver metastasis, those with isolated lung and other organ metastases showed better overall survival rates and tumor-specific survival rates. The patients with liver, lung, multiple, and other organ metastases or of age >60 years were the independent predictors of poor prognosis. Conclusions. The patients with isolated lung and other organ metastases demonstrated better survival outcomes as compared to those with isolated liver metastasis. The patients with nonorgan metastasis demonstrated the best survival outcomes, while those with multiple metastases showed the worst survival outcomes. Further studies are needed to determine a highly selected subset of patients, who might benefit from surgery or chemotherapy.

scholarly journals Should Contrast-Enhanced Harmonic Endoscopic Ultrasound Be Incorporated into the International Consensus Guidelines to Determine the Appropriate Treatment of Intraductal Papillary Mucinous Neoplasm?

2021 ◽  
Vol 10 (9) ◽  
pp. 1818
Author(s):  
Tomohiro Yamazaki ◽  
Mamoru Takenaka ◽  
Shunsuke Omoto ◽  
Tomoe Yoshikawa ◽  
Rei Ishikawa ◽  
...  
Keyword(s):  
Intraductal Papillary Mucinous Neoplasm ◽  
Predictive Value ◽  
Diagnostic Value ◽  
Consensus Guidelines ◽  
International Consensus ◽  
Mucinous Neoplasm ◽  
Appropriate Treatment ◽  
Contrast Enhanced ◽  
Diagnostic Values ◽  
International Consensus Guidelines

This study aimed to investigate whether the incorporation of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) into the international consensus guidelines (ICG) for the management of intraductal papillary mucinous neoplasm (IPMN) could improve its malignancy diagnostic value. In this single-center retrospective study, 109 patients diagnosed with IPMN who underwent preoperative CH-EUS between March 2010 and December 2018 were enrolled. We analyzed each malignancy diagnostic value (sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV)) by replacing fundamental B-mode EUS with CH-EUS as the recommended test for patients with worrisome features (WF) (the CH-EUS incorporation ICG) and comparing the results to those obtained using the 2017 ICG. The malignancy diagnostic values as per the 2017 ICG were 78.9%, 42.3%, 60.0%, and 64.7% for Se, Sp, PPV, and NPV, respectively. The CH-EUS incorporation ICG plan improved the malignancy diagnostic values (Se 78.9%/Sp, 53.8%/PPV, 65.2%/NPV 70.0%). CH-EUS may be useful in determining the appropriate treatment strategies for IPMN.

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