scholarly journals Chemical Studies on Isocyanates. IV. Reactions of isocyoanates with Carboxylic Acids. Part 3. Formation of Amides, Ureas and Carboxylic Acid Anhydrides by the Decomposition and the Disproportionation of Addition Products of Isocyanates with Carboxylic Acids

1959 ◽  
Vol 80 (5) ◽  
pp. 506-509
Author(s):  
Shoichiro OZAKI ◽  
Shoichi SHIMADA
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Chemical Studies ◽  
Acid Anhydrides

Isocarbostyrils. II. The Conversion of 2-Methyl-4-acyl-5-nitroisocarbostyrils to 2-Substituted Indole-4-carboxylic Acids

1971 ◽  
Vol 49 (17) ◽  
pp. 2797-2802 ◽  
Author(s):  
D. E. Horning ◽  
G. Lacasse ◽  
J. M. Muchowski
Keyword(s):  
Sulfuric Acid ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Alkaline Hydrolysis ◽  
Mannich Reaction ◽  
Reductive Cyclization ◽  
Acid Catalyzed ◽  
Acid Anhydrides ◽  
Hydrolysis Of ◽  
Derivatives Of

The sulfuric acid catalyzed acylation of 2-methyl-5-nitroisocarbostyril with carboxylic acid anhydrides gave the corresponding 4-acylated derivatives 3, which underwent reductive cyclization to 2-substituted derivatives of 4-methyl-1,3,4,5-tetrahydropyrrolo[4.3.2.de]isoquinolin-5-one (4). Alkaline hydrolysis of the six-membered lactam in 4 was accompanied by a retro-Mannich reaction to produce 2-substituted indole-4-carboxylic acids in about 40 % overall yield from 3.

Reactions of Chromyl Chloride with Carboxylic Acids and Carboxylic Acid Anhydrides

1985 ◽  
Vol 40 (2) ◽  
pp. 247-250 ◽  
Author(s):  
Ramesh Kapoor ◽  
Pratibha Kapoor ◽  
Ramneek Sharma
Keyword(s):  
Magnetic Susceptibility ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Magnetic Moment ◽  
Antiferromagnetic Coupling ◽  
Chromyl Chloride ◽  
Polar Organic Solvents ◽  
Uv Visible ◽  
Acid Anhydrides ◽  
Polymeric Structures

Abstract Chromyl Chloride reacts with carboxylic acids [RCOOH where R = C2H5, n-C3H7, CH2CI, CHCl2 and CCI3] to give reduced chromium(III) carboxylates, [Cr3 O(OOCR)6 (H2O)3 ]Cl. Magnetic susceptibility, UV-visible and IR measurements are all consistent with their trinuclear basic structures. Reactions of chromyl chloride with carboxylic acid anhydrides [(RCO)2O where R = CH3 , C2H5 and n-C3H7 ] give dinuclear oxo-bridged complexes of the type, [Cr2O(OOOCR)3 ]Cl. These compounds behave as non-electrolytes in polar organic solvents. IR spectra suggest the presence of bridging carboxylato groups containing Cr-O -Cr chains. Their low magnetic moment values suggest polymeric structures exhibiting antiferromagnetic coupling between Cr atoms.

Mild and Efficient Synthesis of Carboxylic Acid Anhydrides from Carboxylic Acids and Triazine Coupling Reagents

2004 ◽  
Vol 34 (18) ◽  
pp. 3349-3358 ◽  
Author(s):  
Zbigniew J. Kamiñski ◽  
Beata Kolesiñska ◽  
Marcinkowska Małgorzata
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Efficient Synthesis ◽  
Coupling Reagents ◽  
Acid Anhydrides

Synthesis of 3-(Cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8- carboxylic Acids Via an Efficient Three-component Condensation Reaction between Cyclohexylisocyanide and 2-Aminopyridine-3-carboxylic Acid in the Presence of Aromatic Aldehyde

2018 ◽  
Vol 21 (4) ◽  
pp. 298-301 ◽  
Author(s):  
Ghasem Marandi
Keyword(s):  
Biological Sciences ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
High Performance ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
New Materials ◽  
One Pot ◽  
High Yields ◽  
Benzaldehyde Derivatives

Aim and Objective: The reaction of cyclohexylisocyanide and 2-aminopyridine-3- carboxylic acid in the presence of benzaldehyde derivatives in ethanol led to 3-(cyclohexylamino)-2- arylimidazo[1,2-a]pyridine-8-carboxylic acids in high yields. In a three component condensation reaction, isocyanide reacts with 2-aminopyridine-3-carboxylic acid and aromatic aldehydes without any prior activation. Material and Methods: The synthesized products have stable structures which have been characterized by IR, 1H, 13C and Mass spectroscopy as well as CHN-O analysis. Results: In continuation of our attempts to develop simple one-pot routes for the synthesis of 3- (cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids, aromatic aldehydes with divers substituted show a high performance. Conclusion: In conclusion, this study introduces the art of combinatorial chemistry using a simple one-pot procedure for the synthesis of new materials which are interesting compounds in medicinal and biological sciences.

scholarly journals Propylphosphonic acid anhydride–mediated amidation of Morita–Baylis–Hillman–derived indolizine-2-carboxylic acids

2021 ◽  
pp. 174751982098715
Author(s):  
Khethobole C Sekgota ◽  
Michelle Isaacs ◽  
Heinrich C Hoppe ◽  
Ronnett Seldon ◽  
Digby F Warner ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Coupling Agent ◽  
Methyl Esters ◽  
Acid Anhydride

Propylphosphonic acid anhydride has been successfully used as a coupling agent in the synthesis of a series of indolizine-2-carboxamido derivatives from indolizine-2-carboxylic acid and its 3-acetylated analogue. The acid substrates were obtained by saponification of the corresponding methyl esters produced, in turn, selectively and efficiently, by time-controlled cyclisation of a single Morita–Baylis–Hillman adduct. Various amino and hydrazino compounds with medicinal potential have been used to prepare indolizine-2-carboxamido and hydrazido derivatives.

Biological Activity of Novel N-Substituted Amides of endo-3- (3-Methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene-2- carboxylic Acid and N-Substituted Amides of 1-(5-Methylthio- 1,2,4-triazol-3-yl)cyclohexane-2-carboxylic Acids

2012 ◽  
Vol 67 (3-4) ◽  
pp. 123-128
Author(s):  
Anna Pachuta-Stec ◽  
Urszula Kosikowska ◽  
Anna Chodkowska ◽  
Monika Pitucha ◽  
Anna Malm ◽  
...  
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Condensation Reaction ◽  
Primary Amines ◽  
Pharmacological Activities

N-Substituted amides of endo-3-(3-methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene- 2-carboxylic acid and 1-(5-methylthio-1,2,4-triazol-3-yl)cyclohexane-2-carboxylic acid were prepared by the condensation reaction of endo-S-methyl-N1-(bicyclo[2.2.1]hept-5-ene-2,3- dicarbonyl)isothiosemicarbazide and S-methyl-N1-(cyclohexane-2,3-dicarbonyl)isothiosemicarbazide with primary amines. The synthesized compounds were screened for their microbiological and pharmacological activities

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