scholarly journals Quercetin Attenuates Oxygen–Glucose Deprivation- and Excitotoxin-Induced Neurotoxicity in Primary Cortical Cell Cultures

2003 ◽  
Vol 26 (4) ◽  
pp. 544-546 ◽  
Author(s):  
Hyun Joo Ha ◽  
Yong Soo Kwon ◽  
Shin Mi Park ◽  
Taekyun Shin ◽  
Jun Hong Park ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Cortical Cell ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Cortical Cell Cultures ◽  
Primary Cortical Cell

Oxygen or glucose deprivation-induced neuronal injury in cortical cell cultures is reduced by tetanus toxin

Neuron ◽  
1992 ◽  
Vol 8 (5) ◽  
pp. 967-973 ◽  
Author(s):  
H. Monyer ◽  
R.G. Giffard ◽  
D.M. Hartley ◽  
L.L. Dugan ◽  
M.P. Goldberg ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Tetanus Toxin ◽  
Cortical Cell ◽  
Neuronal Injury ◽  
Glucose Deprivation ◽  
Cortical Cell Cultures

Ethanol and glucose-deprivation neurotoxicity in cortical cell cultures

Metabolism ◽  
1994 ◽  
Vol 43 (9) ◽  
pp. 1108-1113 ◽  
Author(s):  
S.P. Singh ◽  
S. Ehmann ◽  
A.K. Snyder
Keyword(s):  
Cell Cultures ◽  
Cortical Cell ◽  
Glucose Deprivation ◽  
Cortical Cell Cultures

scholarly journals Secobarbital Attenuates Excitotoxicity but Potentiates Oxygen—Glucose Deprivation Neuronal Injury in Cortical Cell Culture

1993 ◽  
Vol 13 (5) ◽  
pp. 803-810 ◽  
Author(s):  
Rona G. Giffard ◽  
John H. Weiss ◽  
Raymond A. Swanson ◽  
Dennis W. Choi
Keyword(s):  
Neuronal Death ◽  
Excitatory Amino Acids ◽  
Cortical Cell ◽  
Glucose Deprivation ◽  
Atp Depletion ◽  
Oxygen Glucose Deprivation ◽  
Protective Effects ◽  
Atp Production ◽  
High Concentrations ◽  
Cortical Cell Cultures

We examined the effects of secobarbital and other sedative-hypnotic barbiturates on the neuronal death induced by exposure to excitatory amino acids or deprivation of oxygen or glucose in mouse cortical cell cultures. N-Methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate, and kainate toxicities were attenuated in a concentration-dependent fashion by high concentrations of secobarbital or thiopental. Antagonism of NMDA toxicity was not overcome by increasing NMDA concentration and not mimicked by γ-aminobutyrate. Despite these antiexcitotoxic actions, secobarbital exacerbated the neuronal death induced by deprivation of either glucose alone or oxygen and glucose together; death induced by oxygen deprivation alone was little affected. Thiopental and methohexital also increased oxygen-glucose deprivation injury. A possible explanation for this injury potentiation was provided by the observation that secobarbital enhanced the cellular ATP depletion induced by combined oxygen-glucose deprivation. Deleterious effects on ATP production may counterbalance the protective effects of barbiturates under some conditions.

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