scholarly journals MicroRNA-146a-5p Downregulates the Expression of P-Glycoprotein in Rats with Lithium–Pilocarpine-Induced Status Epilepticus

2019 ◽  
Vol 42 (5) ◽  
pp. 744-750 ◽  
Author(s):  
Xiaolin Deng ◽  
Yiye Shao ◽  
Yangmei Xie ◽  
Yonghao Feng ◽  
Men Wu ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
P Glycoprotein

Research on the Correlation between Neuronal Damage and Drug Resistance Gene Product P-Gp Following Status Epilepsy

2012 ◽  
Vol 550-553 ◽  
pp. 1010-1013
Author(s):  
Song Yan Liu ◽  
Rui Tao Mao ◽  
Hua Cai ◽  
Xue Mei Han
Keyword(s):  
Drug Resistance ◽  
Image Analysis ◽  
Status Epilepticus ◽  
Neuronal Damage ◽  
Intractable Epilepsy ◽  
Neuronal Injury ◽  
Control Group ◽  
Analysis Method ◽  
Image Analysis Method ◽  
P Glycoprotein

Objective: To study the association between neuronal injury following status epilepsy and expression of P-glycoprotein, discuss the association between intractable epilepsy and neuronal injury. Method: To establish a mice status epilepticus model by lithium-pilocarpine injected intraperitoneal, The mice were randomly divided into control group 6h, 12h, 1d, 3d, 5d and 7d after status epilepticus(SE) .To research the neuronal injury by image analysis method, expression of P-gp in blood was studied by flow cyometry .To analyze the association between neuronal injury and expression of P-gp by Pearson statistics. Result: The neuronal injury was observed after status epilepsy. Neuronal injury is most obvious 3-7 days after status epilepsy, expression of P-gp increased simultaneously. The severity of neuronal injury has a positive correlation to expression of P-gp. Conclusion: Association between intractable epilepsy and neuronal injury exists.

scholarly journals Pilocarpine-Induced Status Epilepticus Is Associated with P-Glycoprotein Induction in Cardiomyocytes, Electrocardiographic Changes, and Sudden Death

2018 ◽  
Vol 11 (1) ◽  
pp. 21 ◽  
Author(s):  
Jerónimo Auzmendi ◽  
Bruno Buchholz ◽  
Jimena Salguero ◽  
Carlos Cañellas ◽  
Jazmín Kelly ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Sudden Death ◽  
P Glycoprotein ◽  
Electrocardiographic Changes

scholarly journals HMGB1 regulates P-glycoprotein expression in status epilepticus rat brains via the RAGE/NF-κB signaling pathway

2017 ◽  
Vol 16 (2) ◽  
pp. 1691-1700 ◽  
Author(s):  
Yuan Xie ◽  
Nian Yu ◽  
Yan Chen ◽  
Kang Zhang ◽  
Hai-Yan Ma ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Signaling Pathway ◽  
P Glycoprotein

scholarly journals Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate

2012 ◽  
Vol 14 (1) ◽  
pp. 87-96 ◽  
Author(s):  
Stina Syvänen ◽  
Maarten Schenke ◽  
Dirk-Jan van den Berg ◽  
Rob A. Voskuyl ◽  
Elizabeth C. de Lange
Keyword(s):  
Status Epilepticus ◽  
P Glycoprotein

Over-expression of P-glycoprotein in the canine brain following spontaneous status epilepticus

2009 ◽  
Vol 83 (2-3) ◽  
pp. 144-151 ◽  
Author(s):  
A. Pekcec ◽  
B. Unkrüer ◽  
V. Stein ◽  
J.P. Bankstahl ◽  
J. Soerensen ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Over Expression ◽  
P Glycoprotein ◽  
Canine Brain
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