Pilocarpine-Induced Status Epilepticus Is Associated with P-Glycoprotein Induction in Cardiomyocytes, Electrocardiographic Changes, and Sudden Death

Often, epileptics die at the time of a pronounced seizure attack, especially in status epilepticus; otherwise they die either at the time of the attack, or immediately after it in an unconscious state, from completely random circumstances, which are sometimes completely impossible to prevent even with careful observation of the patient and which are fatal for the given subject. All cases of this kind are very instructive, indicating once again what kind of careful supervision epileptics require, even in the setting of special institutions, where they seem to be in the greatest safety from death due to lack of preventive measures or oversight on the part of the caring staff.

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MicroRNA-146a-5p Downregulates the Expression of P-Glycoprotein in Rats with Lithium–Pilocarpine-Induced Status Epilepticus

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.b18-00937 ◽

2019 ◽

Vol 42 (5) ◽

pp. 744-750 ◽

Cited By ~ 5

Author(s):

Xiaolin Deng ◽

Yiye Shao ◽

Yangmei Xie ◽

Yonghao Feng ◽

Men Wu ◽

...

Keyword(s):

Status Epilepticus ◽

P Glycoprotein

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Status Epilepticus Changes the Ionic Homeostasis of the Amygdala and May Be Related to Sudden Death in Epilepsy

XXVI Brazilian Congress on Biomedical Engineering - IFMBE Proceedings ◽

10.1007/978-981-13-2517-5_95 ◽

2019 ◽

pp. 629-633

Author(s):

Luiz Eduardo Canton Santos ◽

Sílvia Cristina Braga da Silva ◽

Antônio Márcio Rodrigues ◽

Fúlvio Alexandre Scorza ◽

Carla Alessandra Scorza ◽

...

Keyword(s):

Status Epilepticus ◽

Sudden Death ◽

Ionic Homeostasis

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Research on the Correlation between Neuronal Damage and Drug Resistance Gene Product P-Gp Following Status Epilepsy

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.550-553.1010 ◽

2012 ◽

Vol 550-553 ◽

pp. 1010-1013

Author(s):

Song Yan Liu ◽

Rui Tao Mao ◽

Hua Cai ◽

Xue Mei Han

Keyword(s):

Drug Resistance ◽

Image Analysis ◽

Status Epilepticus ◽

Neuronal Damage ◽

Intractable Epilepsy ◽

Neuronal Injury ◽

Control Group ◽

Analysis Method ◽

Image Analysis Method ◽

P Glycoprotein

Objective: To study the association between neuronal injury following status epilepsy and expression of P-glycoprotein, discuss the association between intractable epilepsy and neuronal injury. Method: To establish a mice status epilepticus model by lithium-pilocarpine injected intraperitoneal, The mice were randomly divided into control group 6h, 12h, 1d, 3d, 5d and 7d after status epilepticus(SE) .To research the neuronal injury by image analysis method, expression of P-gp in blood was studied by flow cyometry .To analyze the association between neuronal injury and expression of P-gp by Pearson statistics. Result: The neuronal injury was observed after status epilepsy. Neuronal injury is most obvious 3-7 days after status epilepsy, expression of P-gp increased simultaneously. The severity of neuronal injury has a positive correlation to expression of P-gp. Conclusion: Association between intractable epilepsy and neuronal injury exists.

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