scholarly journals Inclusion complexes of cinnarizine with .BETA.-cyclodextrin in aqueous solution and in the solid state.

1984 ◽  
Vol 32 (10) ◽  
pp. 4179-4184 ◽  
Author(s):  
TADAKAZU TOKUMURA ◽  
HARUHISA UEDA ◽  
YUKI TSUSHIMA ◽  
MASAYOSHI KASAI ◽  
MASANORI KAYANO ◽  
...  
2021 ◽  
Vol 11 (14) ◽  
pp. 6597
Author(s):  
Aldo Arrais ◽  
Marta Manzoni ◽  
Alessia Cattaneo ◽  
Valentina Gianotti ◽  
Nadia Massa ◽  
...  

Essential oils are widely recognized as natural alternatives to pharmaceutical antibacterial and antifungal agents. With respect to standard pharmaceutics, the advantages of essential oils are their (i) low production costs, (ii) lack of chemical and biochemical drawbacks that are intrinsic to the synthetic production process and (iii) good tolerance by humans. On the other hand, the liquid nature of essential oils poses concerns about their actual application in different therapeutic issues regarding their persistence and the ability to control or prolong drug release. In this study, two essential oils from oregano and winter savory showing antibacterial and antifungal features were complexed in a solid state with beta-cyclodextrin. Host–guest inclusion complexes were characterized using FT-IR spectroscopy, ESI-MS and GC-MS techniques. Manyfold terpenic and non-terpenic components of the oils could be observed and unambiguously identified as being included inside the carbohydrate hosts. Many of them provided a specific biocidal action. Indeed, essential oil host–guest inclusion products were tested against two Candida species and an S. aureus reference strain, showing that the oils effectively maintained their liquid performances. Solid-state tablets of the essential oil inclusion complexes embedded in polyvinylpyrrolidone could be obtained. These results pave the way for the solid-state application of essential oils in antibacterial and antifungal pharmaceutical treatments.


2008 ◽  
Vol 62 (1-2) ◽  
pp. 117-125 ◽  
Author(s):  
Mariana Spulber ◽  
Mariana Pinteala ◽  
Adrian Fifere ◽  
Valeria Harabagiu ◽  
Bogdan C. Simionescu

ARKIVOC ◽  
2002 ◽  
Vol 2002 (2) ◽  
pp. 87-96
Author(s):  
Carmen Topala ◽  
Gabriela Ionita ◽  
Viorica Meltzer ◽  
Elena Pincu ◽  
Constantin Draghici

RSC Advances ◽  
2017 ◽  
Vol 7 (65) ◽  
pp. 40803-40812 ◽  
Author(s):  
Aditi Roy ◽  
Mahendra Nath Roy

Encapsulation of trihexyltetradecylphosphonium chloride inside α and β-cyclodextrins in both aqueous solution and solid state with 1 : 1 stoichiometry.


RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 100016-100027 ◽  
Author(s):  
Aditi Roy ◽  
Subhadeep Saha ◽  
Biswajit Datta ◽  
Mahendra Nath Roy

The encapsulation of [BMIm]Cl and [BMP]Cl within α and β-cyclodextrin in both the solid state and aqueous solution with 1 : 1 supramolecular assembly.


2021 ◽  
Author(s):  
Long Cao ◽  
Han-Ling Guo ◽  
Rui Lian Lin ◽  
Li-Fei Tian ◽  
Zhi-Hua Zhang ◽  
...  

Using multiple techniques, this work studied the binding behaviors of decamethylcucurbit[5]uril (Me10Q[5]) with o-, m- and p-phenylenediamine (PDA) isomers both in solid state and in aqueous solution. Experimental data indicate...


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