good tolerance
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Author(s):  
Yiagnigni Mfopou E ◽  

The coronavirus disease 19 (COVID-19) has been a pandemic since February 2020. So far, no effective treatment has been found. WHO has recommended research on medicinal plants as an alternative treatment course. Several studies conducted on Thymus vulgaris have established its antioxidant, antiviral and immunomodulatory properties that induce the elimination of viruses such as Herpes simplex Virus 1 and 2. Following this, we initiated a study entitled Efficacy and tolerance of Thymus vulgaris extract in patients with coronavirus 2019. Material and method: Thymus vulgaris powder was used in this study. A consent letter and a questionnaire about the patients’ symptoms were prepared to be used by a research investigator. According to the statistical calculations of this cohort study, 161 patients testing positive for COVID-19 PCR were consecutively recruited, of which 75 patients were not exposed to Thymus vulgaris and 86 patients were exposed. Information from the questionnaire was gathered from the patients before the initiation of conventional treatment (vitamin C 1000 1 tablet/day, Zinc 20 mg 1tablet/day, Azithromycin 500 1cp day and amoxicillin/clavulamic acid 1g/125 1 tablet per 12 hours for six days in both cohorts) and by combining Thymus vulgaris (1 teaspoon, i.e. 5g, in 100 ml of hot water to be taken every 8 hours) by the patients in the exposed cohort. After three days of this treatment, the evaluative part of the questionnaire was completed to assess the impact of taking or not taking Thymus vulgaris on early symptoms and tolerance; on the 10th day after the start of treatment, the PCR control test was carried out. Thereafter, the various statistical analyses were performed. Results: Statistical evaluation after three days of treatment shows that taking Thymus vulgaris has a statistically significant positive effect on cough (p <0.01), dyspnoea (p <0.001), dizziness (p <0.029), fatigue (p <0.001), anorexia (p <0.001), chest pain (p <0.001), fever (p <0.024), agueusia (p <0.029) and anosmia (p <0.001). There was a significant decrease in neutrophils (p <0.01); in addition, the lymphocyte count increased significantly (p <0.001) as did the serum calcium level (p <0.03). Blood urea level decreased significantly (p <0.01). Significant negative results of the COVID-19 PCR were obtained at Day 10 in the exposed group (p <0.001). In addition, there was no significant change in other biological parameters such as creatinine, blood glucose, aspartate amino transferase. Conclusion: Results of this study show that the use of the powder of Thymus vulgaris, a medicinal plant, with antioxidant, immunomodulatory and antiviral properties, was very effective on coronavirus-induced symptoms and virus elimination. Moreover, there was good tolerance after taking Thymus vulgaris.


2021 ◽  
Vol 36 ◽  
pp. 129-131
Author(s):  
Kumarswamy Dudala ◽  
Sujatha Ramabhatta ◽  
S. R. Lakshmipathy ◽  
B. G. Raghunandan ◽  
K. Rashmi ◽  
...  

Infantile hemangiomas (IH) are most common vascular tumors. It usually resolves on its own, treatment becomes necessary if there is disease progression. Oral propranolol is a medical therapeutic option for complicated IH with impressive efficacy and generally good tolerance. We report a case of deep seated IH of the cheek in a 4 month old successfully treated with propranolol.


2021 ◽  
pp. 7-11
Author(s):  
A. E. Babich ◽  
E. V. Luchinina ◽  
O. G. Kompaniets ◽  
N. A. Zubareva

The aim of the study was to assess the tolerability and impact on the quality of life of pharmacotherapy for gastric ulcer, erosive gastritis using regimens including rebamipide. The quality of life of patients was assessed using the SF-36 questionnaire. Pharmacotherapy of gastric ulcer with the inclusion of rebamipide as part of the conventional treatment regimen provides data comparable to the healthy group on the scales of physical functioning, role functioning due to physical condition, pain intensity, general health, and vital activity. The results of our own research and data from literary sources indicate that rebamipide is a drug with a confident evidence base, good tolerance and safety of use.


Plants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2666
Author(s):  
Stanko Vršič ◽  
Klemen Vršič

Renewed interest in varieties that are more tolerant to diseases has emerged, which is mainly due to increased awareness by producers and consumers regarding the impact of phytochemicals in the environment. This paper describes the first Slovenian grapevine variety ‘Pinore’ crossed between the Vitis vinifera L. ‘Pinot Noir’ clone Mf and ‘Regent’ vines. The aim was to create an early ripening grape cultivar that has a good tolerance to biotic stress (e.g., downy and powdery mildew, botrytis) combined with the benefits of established cultivars and their intense wine colors. Some ampelographic characteristics of young shoots, mature leaves, bunches, and berries are presented, and its major agronomic traits, ripening time, grape yield, quality performances, and disease resistance were evaluated over a three-year period (2014–2017). Wine sensory analyses were performed and compared with the international variety ‘Pinot Noir’. The examined genotype showed good agronomic performance and a high wine quality as far as the content of polyphenols is concerned, especially in terms of anthocyanins and tolerance to diseases (Ren3/9 and Rpv3.1); it is significantly different compared to the reference variety ‘Pinot Noir’. In terms of ampelographic characteristics, the main differences are in the number of leaf lobes, the depth of the lateral sinuses, and the content of anthocyanins in its flesh. The investigated genotype has been proposed to the Committee of new varieties in Slovenia for the variety recognition procedure, and completion of the procedure planned for the end of 2023.


2021 ◽  
Vol 26 (5) ◽  
pp. 44-50
Author(s):  
E. V. Ekusheva ◽  
A. R. Artemenko ◽  
E. V. Shirshova ◽  
P. E. Sokov ◽  
A. M. Plieva

Patients with chronic migraine are characterized by frequent severe headache attacks, polypharmacy (painkillers), insufficient effect of preventive therapy, and a decrease in the quality of life. The aim of a prospective open-label study was the evaluation of the efficacy and tolerance of Erenumab (Irinex) in the treatment of patients with chronic migraine in real clinical practice.Material and methods. 48 patients with chronic migraine were clinically and neurologically examined (35.5 [19; 56]; diagnosis was established according to the criteria of ICHD classification and diagnosis of migraine. Medical monitoring period was 3 months. Clinical and neurological testing and subcutaneous administration of Erenumab (Irinex) 70 mg were performed once a month during the whole period.Results. Safety, good tolerance and an obvious significant clinical effect were noted when using Erenumab (Irinex) 70 mg. It led to a significant improvement in clinical score and the course of chronic migraine, the effectiveness of rapid relief of symptoms and significant reduction in the need for painkillers in most patients. The best results were found after 3 months of therapy.


Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2781
Author(s):  
Diletta Mazzantini ◽  
Francesco Celandroni ◽  
Marco Calvigioni ◽  
Adelaide Panattoni ◽  
Roberto Labella ◽  
...  

The quality control of probiotic products is the focus of numerous organizations worldwide. Several studies have highlighted the poor microbiological quality of many commercial probiotic formulations in terms of the identity of the contained microorganisms, viability, and purity, thus precluding the expected health benefits and representing a potential health risk for consumers. In this paper, we analyzed the contents of two probiotic formulations, one composed of an encapsulated mixture of lactobacilli and bifidobacteria, and one by a lyophilized yeast. The microorganisms contained in the products were quantified and identified using up-to-date methodologies, such as MALDI-TOF MS and metagenomic analysis. Moreover, as acid and bile tolerance is included among the criteria used to select probiotic microorganisms, in vitro tests were performed to evaluate the behavior of the formulations in conditions mimicking the harsh gastric environment and the intestinal fluids. Our results indicate the high quality of the formulations in terms of the enumeration and identification of the contained organisms, as well as the absence of contaminants. Moreover, both products tolerated the acidic conditions well, with encapsulation providing further protection for the microorganisms. A good tolerance to the simulated artificial intestinal conditions was also evidenced for both preparations.


Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_5) ◽  
Author(s):  
W Messadi ◽  
A Salmi ◽  
N Cherif

Abstract Background Biotherapy result of spectacular advances in genetics and research in molecular and cellular biology, has considerably improved the management of rheumatic and autoinflammatory diseases in children. The Objective is to assess the efficacy and tolerance of biotherapy in pediatrics Methods A retro-prospective study was carried out in the Pediatric Department B at the pediatric rheumatology consultation, university hospital center. An operating sheet was drawn up including epidemiological, clinical, paraclinical and therapeutic data of the cases diagnosed as well as their evolution on biotherapy. Results 26 children received treatment with biotherapy. 73% presented with JIA (54% systemic, 19% polyarticular with positive RF, 19% severe uveitis, and 4% familial Mediterranean fever. 4% behçet disease The mean time to start biotherapy was 12 months [2–48]. There is a clear clinical and biological improvement for 93% of patients. Etanercept was effective in polyarticular-progressive JIA, Adalimumab in oligoarthritis with severe uveitis, Tocilizumab in systemic forms of JIA and Anakinra in familial Mediterranean fever resistant to colchicine and systemic arthritis. The adverse reactions noted were: one case of tuberculosis, hepatic cytolysis in 4 cases, and one case of psoriasis. Conclusion The introduction of biotherapy in pediatric has considerably improved the management of inflammatory rheumatic diseases and transformed the prognosis of these chronic diseases. The maintenance of the good response to treatment and the good tolerance of biotherapy must be evaluated prospectively over the long term.


Pathogens ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1412
Author(s):  
Fabiana Furci ◽  
Luisa Ricciardi

Background: Cross-reactivity between pollens and plant food has been widely described. Pollen extract subcutaneous immunotherapy in patients with pollens and plant food allergy has been shown to improve tolerance not only to inhalant allergens but also to reduce symptoms in patients with various food allergies. Methods: We retrospectively report our experience with 15 female patients with a positive history for moderate, persistent allergic rhinitis due to grass pollen and oropharyngeal symptoms after ingestion of different plant food. These patients followed a five-grass pollen sublingual tablet immunotherapy for three years in a discontinuous pre-co-seasonal scheme. Results: All 15 patients treated with the 5-grass pollen sublingual tablet immunotherapy, taken once daily for 3 years on a 7-month course, showed improved ocular/nasal symptoms, with a reduction in the use of symptomatic drugs (e.g., nasal corticosteroids and H1 antihistamines). After the first seven-month course of immunotherapy, all patients declared a good tolerance to the intake of fruits and vegetables, and in particular, good tolerance to the offending foods. Conclusions: In conclusion, we have observed improvement of both respiratory and plant food allergies after sublingual immunotherapy (SLIT) with a five-grass pollen tablet.


2021 ◽  
Vol 97 (4) ◽  
pp. 107-112
Author(s):  
Andrey A. Martynov ◽  
Anna V. Vlasova

The article describes a clinical case of vaccination with the drug "Kovivac" of a patient of an older age group with an established diagnosis of bullous pemphigoid. Scientific data on the prevalence of bullous dermatoses in the Russian Federation (true pemphigus, Lever's bullous pemphigoid, Dhring's herpetiformis dermatitis) are presented. There is a good tolerance of the Kovivac vaccine in a patient suffering from bullous pemphigoid, which allows vaccination, in fact, without interrupting patients from their daily activities and without diverting the resources of the healthcare system to unreasonable inpatient care. The decision to vaccinate should be made on the basis of data on the available indications / contraindications for drugs, taking into account the individual anamnestic data of patients. In addition, it should be borne in mind that until now, all links of the infectious process caused by SARS-CoV-2 have not been fully studied. In this regard, before vaccination, patients must be informed of the need to comply with the anti-epidemic measures recommended for the prevention of coronavirus infection (COVID-19), even after full vaccination, as well as dynamic observation by specialist doctors.


2021 ◽  
Author(s):  
guixiang kong ◽  
xiaolu Su ◽  
xiaojun Huang

Abstract Gastrointestinal leiomyosarcoma remains relatively rare,accounting for only 1% of gastric tumors,since the use of c-kit staining was first described in 1998 to differentiate gastrointestinal stromal tumors.In this case report,we described the clinical manifestations,endoscopic features, and pathological immunohistochemical features of the gastric leiomyosarcoma.We found that endoscopic ultrasonography has great value in the diagnosis of gastric leiomyosarcoma,and that minimally invasive endoscopic treatment is safe and effective.Particularly,this case highlights that the early-stage lesions can be treated with minimally invasive endoscopic treatment with good tolerance and satisfactory clinical results.Endoscopic submucosal dissection is thus effective for treating gastric leiomyosarcoma,with promising prospects for clinical application.


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