ACID-BASE BALANCE ACROSS PREVIOUSLY ACTIVE AND INACTIVE MUSCLE FOLLOWING SHORT-TERM, HIGH INTENSITY EXERCISE

Given the ergogenic properties of β-alanyl-L-histidine (carnosine) in skeletal muscle, it can be hypothesized that elevated levels of circulating carnosine could equally be advantageous for high-intensity exercises. Serum carnosinase (CN1), the enzyme hydrolyzing the dipeptide, is highly active in the human circulation. Consequently, dietary intake of carnosine usually results in rapid degradation upon absorption, yet this is less pronounced in subjects with low CN1 activity. Therefore, acute carnosine supplementation before high-intensity exercise could be ergogenic in these subjects. In a cross-sectional study, we determined plasma CN1 activity and content in 235 subjects, including 154 untrained controls and 45 explosive and 36 middle- to long-distance elite athletes. In a subsequent double-blind, placebo-controlled, crossover study, 12 men performed a cycling capacity test at 110% maximal power output (CCT 110%) following acute carnosine (20 mg/kg body wt) or placebo supplementation. Blood samples were collected to measure CN1 content, carnosine, and acid-base balance. Both male and female explosive athletes had significantly lower CN1 activity (14% and 21% lower, respectively) and content (30% and 33% lower, respectively) than controls. Acute carnosine supplementation resulted only in three subjects in carnosinemia. The CCT 110% performance was not improved after carnosine supplementation, even when accounting for low/high CN1 content. No differences were found in acid-base balance, except for elevated resting bicarbonate following carnosine supplementation and in low CN1 subjects. In conclusion, explosive athletes have lower serum CN1 activity and content compared with untrained controls, possibly resulting from genetic selection. Acute carnosine supplementation does not improve high-intensity performance.

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The influence of alkalosis on repeated high-intensity exercise performance and acid–base balance recovery in acute moderate hypoxic conditions

European Journal of Applied Physiology ◽

10.1007/s00421-018-3975-z ◽

2018 ◽

Vol 118 (12) ◽

pp. 2489-2498 ◽

Cited By ~ 2

Author(s):

Lewis Anthony Gough ◽

Danny Brown ◽

Sanjoy K. Deb ◽

S. Andy Sparks ◽

Lars R. McNaughton

Keyword(s):

Exercise Performance ◽

High Intensity ◽

High Intensity Exercise ◽

Acid Base Balance ◽

Acid Base ◽

Balance Recovery ◽

Hypoxic Conditions ◽

Base Balance

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Short Term Effects of Muzolimine on Electrolytes and Acid-Base Balance

Diuretics: Basic, Pharmacological, and Clinical Aspects ◽

10.1007/978-1-4613-2067-8_130 ◽

1987 ◽

pp. 509-511

Author(s):

E. Boschetti ◽

C. Minestrini ◽

A. Scortecci ◽

S. Cipolloni

Keyword(s):

Acid Base Balance ◽

Acid Base ◽

Short Term ◽

Base Balance ◽

Short Term Effects

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Renal function and acid-base balance in the toad Bufo marinus during short-term dehydration

Canadian Journal of Zoology ◽

10.1139/z86-157 ◽

1986 ◽

Vol 64 (5) ◽

pp. 1054-1057 ◽

Cited By ~ 10

Author(s):

B. L. Tufts ◽

D. P. Toews

Keyword(s):

Renal Function ◽

Bufo Marinus ◽

Ambient Water ◽

Acid Base Balance ◽

Acid Base ◽

Short Term ◽

Base Balance ◽

Toad Bufo ◽

Normal Acid ◽

Tubular Component

Specimens of Bufo marinus (L.) were cannulated in both ureters to partition between the regulatory contributions of the kidney and urinary bladder. These bladder-bypassed animals were then exposed to 10 h of dehydration in air and renal function and acid–base balance were assessed. The results indicated that the kidney showed an almost immediate response to dehydration which consisted of a large glomerular and smaller tubular component. Bypassing and emptying of the bladder and the removal of the ambient water had no effect on the animal's ability to maintain normal acid–base balance.

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