Perceived Exertion in Fatiguing Illness: Civilians with Chronic Fatigue Syndrome

2003 ◽  
Vol 35 (4) ◽  
pp. 563-568 ◽  
Author(s):  
DANE B. COOK ◽  
PAUL R. NAGELKIRK ◽  
ARNOLD PECKERMAN ◽  
ASHOK POLURI ◽  
JOHN J. LAMANCA ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Perceived Exertion ◽  
Chronic Fatigue ◽  
Fatigue Syndrome

Perceived Exertion in Fatiguing Illness: Gulf War Veterans with Chronic Fatigue Syndrome

2003 ◽  
Vol 35 (4) ◽  
pp. 569-574 ◽  
Author(s):  
DANE B. COOK ◽  
PAUL R. NAGELKIRK ◽  
ARNOLD PECKERMAN ◽  
ASHOK POLURI ◽  
JOHN J. LAMANCA ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Perceived Exertion ◽  
Chronic Fatigue ◽  
Gulf War ◽  
War Veterans ◽  
Gulf War Veterans ◽  
Fatigue Syndrome

Chronic fatigue syndrome: new evidence for a central fatigue disorder

2003 ◽  
Vol 105 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Evelina GEORGIADES ◽  
Wilhelmina M. H. BEHAN ◽  
Liam P. KILDUFF ◽  
Marios HADJICHARALAMBOUS ◽  
Eileen E. MACKIE ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Chronic Fatigue Syndrome ◽  
Oxygen Uptake ◽  
Perceived Exertion ◽  
Chronic Fatigue ◽  
Rating Of Perceived Exertion ◽  
Time Points ◽  
Fatigue Syndrome ◽  
Rate Limiting

Considerable evidence points towards a prominent role for central nervous system (CNS) mechanisms in the pathogenesis of chronic fatigue syndrome (CFS), a disorder characterized chiefly by persistent, often debilitating, fatigue. We wished to characterize circulating profiles of putative amino acid modulators of CNS 5-hydroxytryptamine (5-HT; serotoninergic) and dopaminergic function in CFS patients at rest, as well as during symptom-limited exercise and subsequent recovery. Groups of 12 CFS patients and 11 age- and sex-matched sedentary controls, with similar physical activity histories, underwent ramp-incremental exercise to the limit of tolerance. Plasma amino acid concentrations, oxygen uptake and ratings of perceived exertion were measured at rest, and during exercise and recovery. Peak oxygen uptake was significantly lower in the CFS patients compared with controls. Rating of perceived exertion in the patients was higher at all time points measured, including at rest, relative to controls. Levels of free tryptophan (free Trp), the rate-limiting 5-HT precursor, were significantly higher in CFS patients at exhaustion and during recovery, whereas concentrations of branched-chain amino acids (BCAA) and large neutral amino acids (LNAA) were lower in CFS patients at exhaustion, and for LNAA also during recovery. Consequently, the [free Trp]/[BCAA] and [free Trp]/[LNAA] ratios were significantly higher in CFS patients, except at rest. On the other hand, levels of tyrosine, the rate-limiting dopaminergic precursor, were significantly lower at all time points in the CFS patients. The significant differences observed in a number of key putative CNS 5-HT and dopaminergic modulators, coupled with the exacerbated perception of effort, provide further evidence for a potentially significant role for CNS mechanisms in the pathogenesis of CFS.

PERCEIVED EXERTION IN CHRONIC FATIGUE SYNDROME

2003 ◽  
Vol 35 (Supplement 1) ◽  
pp. S288
Author(s):  
D B. Cook ◽  
P R. Nagelkirk ◽  
A Poluri ◽  
J Mores ◽  
B Qureishi ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Perceived Exertion ◽  
Chronic Fatigue ◽  
Fatigue Syndrome

scholarly journals Perceived Exertion Is Elevated In Chronic Fatigue Syndrome And Fibromyalgia: A Meta-analysis Of Case-control Studies

2020 ◽  
Vol 52 (7S) ◽  
pp. 497-497
Author(s):  
Jacob B. Lindheimer ◽  
Ellen E. Barhorst ◽  
William E. Andrae ◽  
Tessa J. Rayne ◽  
Michael J. Falvo ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Perceived Exertion ◽  
Meta Analysis ◽  
Chronic Fatigue ◽  
Case Control ◽  
Case Control Studies ◽  
Fatigue Syndrome

Elevated Perceived Exertion in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Meta-analysis

2020 ◽  
Vol 52 (12) ◽  
pp. 2615-2627
Author(s):  
ELLEN E. BARHORST ◽  
WILLIAM E. ANDRAE ◽  
TESSA J. RAYNE ◽  
MICHAEL J. FALVO ◽  
DANE B. COOK ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Perceived Exertion ◽  
Meta Analysis ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome

scholarly journals Markers of Cardiac Autonomic Function During Consecutive Day Peak Exercise Tests in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Maximillian J. Nelson ◽  
Jonathan D. Buckley ◽  
Rebecca L. Thomson ◽  
Clint R. Bellenger ◽  
Kade Davison
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Perceived Exertion ◽  
Maximal Exercise ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Peak Exercise ◽  
Exercise Tests ◽  
Significant Group ◽  
Warm Up ◽  
Fatigue Syndrome

Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have been shown to exhibit altered ventilatory characteristics on the second of two progressive maximal cardiopulmonary exercise tests (CPET) performed on consecutive days. However, maximal exercise can exacerbate symptoms for ME/CFS patients and cause significant post-exertional malaise. Assessment of heart rate (HR) parameters known to track post-exertional fatigue may represent more effective physiological markers of the condition and could potentially negate the need for maximal exercise testing. Sixteen ME/CFS patients and 10 healthy controls underwent a sub-maximal warm-up followed by CPET on two consecutive days. Ventilation, ratings of perceived exertion, work rate (WR) and HR parameters were assessed throughout on both days. During sub-maximal warm-up, a time effect was identified for the ratio of low frequency to high frequency power of HR variability (p=0.02) during sub-maximal warm-up, and for HR at ventilatory threshold (p=0.03), with both being higher on Day Two of testing. A significant group (p<0.01) effect was identified for a lower post-exercise HR recovery (HRR) in ME/CFS patients. Receiver operator characteristic curve analysis of HRR revealed an area under the curve of 74.8% (p=0.02) on Day One of testing, with a HRR of 34.5bpm maximising sensitivity (63%) and specificity (40%) suggesting while HRR values are altered in ME/CFS patients, low sensitivity and specificity limit its potential usefulness as a biomarker of the condition.

Long- and short-term blood pressure andRR-interval variability and psychosomatic distress in chronic fatigue syndrome: authors’ reply 1

1999 ◽  
Vol 97 (3) ◽  
pp. 319 ◽  
Author(s):  
D.A. DUPREZ ◽  
M.L. DE BUYZERE ◽  
B. DRIEGHE ◽  
F. VANHAVERBEKE ◽  
Y. TAES ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Short Term ◽  
Fatigue Syndrome

Diagnostic Concordance Between Categorical and Dimensional Instruments to Assess Personality Disorder in Chronic Fatigue Syndrome

2017 ◽  
Vol 33 (3) ◽  
pp. 158-165
Author(s):  
Natalia Calvo ◽  
Naia Sáez-Francàs ◽  
Sergi Valero ◽  
Jesús Castro-Marrero ◽  
José Alegre Martín ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Chronic Fatigue Syndrome ◽  
Personality Assessment ◽  
Chronic Fatigue ◽  
Specific Pattern ◽  
Harm Avoidance ◽  
Assessment Instrument ◽  
Compulsive Disorder ◽  
Fatigue Syndrome ◽  
Self Transcendence

Abstract. The study examines the relationship between a categorical and a dimensional personality assessment instrument in patients with Chronic Fatigue Syndrome (CFS). A total of 162 CFS patients were included in the study (91.4% women; mean age 47.5 years). All subjects completed the Spanish versions of the Personality Diagnostic Questionnaire-4+ (PDQ-4+) and the Temperament and Character Inventory-Revised (TCI-R). Results: 78 (48.1%) of the patients presented a Personality Disorder (PD), the most frequent being Cluster C, specifically Obsessive-compulsive disorder, followed by Avoidant disorder. PDs showed a specific pattern of correlation with temperament scales. All PD clusters correlated positively with Harm Avoidance and Self-Transcendence, and negatively with Reward Dependence, Self-Directedness, and Cooperativeness. In a logistic regression analysis, Self-Directedness and Cooperativeness predicted PD presence. The findings are consistent with previous studies in non-CFS samples and suggest that the combination of the Temperament and Character dimensions (low Self-Directedness and Cooperativeness and high Harm Avoidance and Self-Transcendence) correlates with PD severity, and that Self-Directedness and Cooperativeness are associated with PD presence in CFS patients. The integration of these two perspectives expands the current comprehension of personality pathology in CFS patients.

Politics, science, and the emergence of a new disease: The case of chronic fatigue syndrome.

1997 ◽  
Vol 52 (9) ◽  
pp. 973-983 ◽  
Author(s):  
Leonard A. Jason ◽  
Judith A. Richman ◽  
Fred Friedberg ◽  
Lynne Wagner ◽  
Renee Taylor ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
New Disease ◽  
Fatigue Syndrome
Sign in / Sign up

Export Citation Format

Share Document