scholarly journals Perceived Exertion Is Elevated In Chronic Fatigue Syndrome And Fibromyalgia: A Meta-analysis Of Case-control Studies

2020 ◽  
Vol 52 (7S) ◽  
pp. 497-497
Author(s):  
Jacob B. Lindheimer ◽  
Ellen E. Barhorst ◽  
William E. Andrae ◽  
Tessa J. Rayne ◽  
Michael J. Falvo ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Perceived Exertion ◽  
Meta Analysis ◽  
Chronic Fatigue ◽  
Case Control ◽  
Case Control Studies ◽  
Fatigue Syndrome

Risk factors for chronic fatigue syndrome/myalgic encephalomyelitis: a systematic scoping review of multiple predictor studies

2007 ◽  
Vol 38 (7) ◽  
pp. 915-926 ◽  
Author(s):  
S. Hempel ◽  
D. Chambers ◽  
A.-M. Bagnall ◽  
C. Forbes
Keyword(s):  
Risk Factors ◽  
Chronic Fatigue Syndrome ◽  
Scoping Review ◽  
Chronic Fatigue ◽  
Case Control ◽  
Myalgic Encephalomyelitis ◽  
Case Control Studies ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Fatigue Syndrome

BackgroundThe aetiology of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is still unknown. The identification of risk factors for CFS/ME is of great importance to practitioners.MethodA systematic scoping review was conducted to locate studies that analysed risk factors for CFS/ME using multiple predictors. We searched for published and unpublished literature in 11 electronic databases, reference lists of retrieved articles and guideline stakeholder submissions in conjunction with the development of a forthcoming national UK guideline. Risk factors and findings were extracted in a concise tabular overview and studies synthesized narratively.ResultsEleven studies were identified that met inclusion criteria: two case-control studies, four cohort studies, three studies combining a cohort with a case-control study design, one case-control and twin study and one cross-sectional survey. The studies looked at a variety of demographic, medical, psychological, social and environmental factors to predict the development of CFS/ME. The existing body of evidence is characterized by factors that were analysed in several studies but without replication of a significant association in more than two studies, and by studies demonstrating significant associations of specific factors that were not assessed in other studies. None of the identified factors appear suitable for the timely identification of patients at risk of developing CFS/ME within clinical practice.ConclusionsVarious potential risk factors for the development of CFS/ME have been assessed but definitive evidence that appears meaningful for clinicians is lacking.

scholarly journals Molecular evidence of autophagy impairment as  serum level of ATG13 is elevated in patients with myalgic encephalomyelitis and chronic fatigue syndrome: two independent case-control studies

2021 ◽  
Author(s):  
Avik Roy ◽  
Carl Gunnar Gottschalk ◽  
Daniel Peterson ◽  
Konstance Knox ◽  
Marco Maynard ◽  
...  
Keyword(s):  
Stress Response ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Case Control ◽  
Myalgic Encephalomyelitis ◽  
Microglial Cells ◽  
Case Control Studies ◽  
Serum Samples ◽  
Fatigue Syndrome ◽  
Independent Case

Abstract Myalgic Encephalomyelitis and chronic fatigue syndrome is a multisystem illness characterized with extreme muscle fatigue associated with pain, neurocognitive impairment, and chronic inflammation. Despite intense investigation, the molecular mechanism of this disease is still unknown. Here we report two independent case-control studies to demonstrate that autophagy proteins are strongly upregulated in the serum of ME/CFS patients indicative of severe impairment in metabolic events of autophagy. Serum samples collected from two healthy and two age-matched patients were assayed for protein aggregation, screened for autophagy-related factors via an antibody array, quantified with densitometric analyses, and finally reconfirmed with ELISA analyses. Based on that double-blinded and gender-balanced study, the levels of ATG13, p62, and alpha-synuclein (α-syn) were found to be consistently elevated in the serum samples of these two ME/CFS patients. Moreover, our microglia-based oxidative stress response study and nitrite analyses indicated that serum samples of ME/CFS patients evoked the production of reactive oxygen species (ROS) and nitrite in human HMC3 microglial cells, whereas neutralization of ATG13 was shown to strongly diminish the production of ROS and nitrite demonstrating the de novo effect bloodborne autophagy factors on inducing the stress response in microglial cells. Collectively, our results indicate that the impairment of autophagy followed by upregulations of autophagy markers especially ATG13 in serum could be a pathological hallmark in ME/CFS.

Elevated Perceived Exertion in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Meta-analysis

2020 ◽  
Vol 52 (12) ◽  
pp. 2615-2627
Author(s):  
ELLEN E. BARHORST ◽  
WILLIAM E. ANDRAE ◽  
TESSA J. RAYNE ◽  
MICHAEL J. FALVO ◽  
DANE B. COOK ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Perceived Exertion ◽  
Meta Analysis ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome

Associations of physical and psychiatric conditions with chronic fatigue syndrome in Germany: an exploratory case-control study

2020 ◽  
pp. 1-7
Author(s):  
Louis Jacob ◽  
Josep Maria Haro ◽  
Karel Kostev
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Regression Model ◽  
Sleep Disorders ◽  
Index Date ◽  
Case Control Study ◽  
Chronic Fatigue ◽  
Case Control ◽  
Fatigue Syndrome ◽  
Psychiatric Conditions ◽  
Control Study

Abstract Background Only a few studies have analyzed the effects of physical and psychiatric conditions on the risk of chronic fatigue syndrome (CFS). Therefore, the goal of this exploratory case-control study was to investigate the associations of physical and psychiatric conditions with CFS in almost 19 800 adults from Germany. Methods This study included patients diagnosed for the first time with CFS in one of 1238 general practices in Germany between 2010 and 2017 (index date). Controls without CFS were matched (1:1) to cases with CFS by sex, age, index year, and practice. Physical and psychiatric conditions diagnosed in the year prior to the index date were included if they were present in at least 3% of patients with CFS. Associations between physical and psychiatric conditions (33 potential independent variables) and CFS (dependent variable) were analyzed in an adjusted conditional logistic regression model, and physical and psychiatric disorders were included in the model using forward stepwise selection. Results This study included 9896 cases with CFS and 9896 controls without CFS [65.1% women; mean (standard deviation) age 49.5 (18.3) years]. Seven conditions were associated with CFS in the adjusted regression model. The disorders displaying the strongest relationship with CFS were cancer [odds ratio (OR) = 2.57, 95% confidence interval (CI) = 2.24–2.95], sleep disorders (OR = 1.88, 95% CI = 1.66–2.12) and depression (OR = 1.77, 95% CI = 1.61–1.95). Conclusions Cancer, sleep disorders, and depression were strongly and positively associated with CFS. Additional studies are needed to gain a better understanding of the mechanisms underlying these relationships.

Perceived Exertion in Fatiguing Illness: Gulf War Veterans with Chronic Fatigue Syndrome

2003 ◽  
Vol 35 (4) ◽  
pp. 569-574 ◽  
Author(s):  
DANE B. COOK ◽  
PAUL R. NAGELKIRK ◽  
ARNOLD PECKERMAN ◽  
ASHOK POLURI ◽  
JOHN J. LAMANCA ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Perceived Exertion ◽  
Chronic Fatigue ◽  
Gulf War ◽  
War Veterans ◽  
Gulf War Veterans ◽  
Fatigue Syndrome

scholarly journals The prevalence of chronic fatigue syndrome/ myalgic encephalomyelitis: a meta-analysis

2013 ◽  
pp. 105 ◽  
Author(s):  
Samantha Johnston ◽  
Brenu ◽  
Don Staines ◽  
Marshall-Gradisnik
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Meta Analysis ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome

scholarly journals Cognitive and behavioural responses to symptoms in adolescents with chronic fatigue syndrome: A case-control study nested within a cohort

2019 ◽  
Vol 24 (3) ◽  
pp. 564-579 ◽  
Author(s):  
Maria Elizabeth Loades ◽  
Katharine Rimes ◽  
Kate Lievesley ◽  
Sheila Ali ◽  
Trudie Chalder
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Physical Functioning ◽  
Predictive Value ◽  
Case Control Study ◽  
Perfect Match ◽  
Chronic Fatigue ◽  
Case Control ◽  
Behavioural Responses ◽  
Fatigue Syndrome ◽  
Control Study

Background: What adolescents think about symptoms and what they do in response could contribute to fatigue maintenance. We compared the cognitive and behavioural responses of adolescents and their parents with chronic fatigue syndrome (CFS; N = 121) and asthma ( N = 27) and explored the predictive value of these variables on fatigue and functioning in CFS. Method: Consecutively referred adolescents with CFS were recruited. Questionnaires, completed by adolescents and parents, assessed fatigue, functioning, mood and cognitive and behavioural responses to symptoms. Age-matched adolescents with asthma completed the same questionnaires. Adolescents with CFS completed questionnaires again approximately 3 months later. Results: Adolescents with CFS scored higher on all unhelpful cognitive and behavioural subscales than adolescents with asthma. Parents’ cognitions about their child’s symptoms were associated with adolescent’s own cognitions. Unhelpful cognitive and behavioural responses, particularly, damage beliefs, predicted subsequent fatigue in CFS, and all-or-nothing behaviour, catastrophising and damage beliefs predicted subsequent physical functioning. Conclusion: Unhelpful cognitive and behavioural responses to symptoms appear to be particularly prominent in adolescents with CFS. There is some consistency but not a perfect match between cognitive and behavioural responses to symptoms reported by adolescents and their parents. These responses could be contributing to fatigue maintenance and disability.

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