Effectiveness of Adjustable-Volume Packed-Bed Reactor with an Ion-Exchange Resin Catalyst for Continuous Production

2016 ◽  
Vol 49 (7) ◽  
pp. 668-672 ◽  
Author(s):  
Kota Yamazaki ◽  
Naomi Shibasaki-Kitakawa ◽  
Kazunori Nakashima ◽  
Toshikuni Yonemoto
2011 ◽  
Vol 174 (1) ◽  
pp. 54-58 ◽  
Author(s):  
Charles Edric T. Co ◽  
Millicent C. Tan ◽  
Joseph Angelo R. Diamante ◽  
Lee Rainier C. Yan ◽  
Raymond R. Tan ◽  
...  

2019 ◽  
Vol 13 (2) ◽  
pp. 542-551 ◽  
Author(s):  
Nattee Akkarawatkhoosith ◽  
Amaraporn Kaewchada ◽  
Chawalit Ngamcharussrivichai ◽  
Attasak Jaree

2012 ◽  
Vol 8 ◽  
pp. 227-233 ◽  
Author(s):  
Nan Wang ◽  
Ronghua Wang ◽  
Xia Shi ◽  
Gang Zou

A clean process has been developed for the synthesis of 2-adamantylphenol derivatives through adamantylation of substituted phenols with adamantanols catalyzed by commercially available and recyclable ion-exchange sulfonic acid resin in acetic acid. The sole byproduct of the adamantylation reaction, namely water, could be converted into the solvent acetic acid by addition of a slight excess of acetic anhydride during the work-up procedure, making the process waste-free except for regeneration of the ion-exchange resin, and facilitating the recycling of the resin catalyst. The ion-exchange sulfonic acid resin catalyst could be readily recycled by filtration and directly reused at least ten times without a significant loss of activity. The key intermediate of adapalene, 2-(1-adamantyl)-4-bromophenol, could be produced by means of this waste-free process.


2008 ◽  
Vol 25 (6) ◽  
pp. 1350-1354 ◽  
Author(s):  
Ji-Yeon Park ◽  
Deog-Keun Kim ◽  
Zhong-Ming Wang ◽  
Joon-Pyo Lee ◽  
Soon-Chul Park ◽  
...  

2010 ◽  
Vol 24 (6) ◽  
pp. 3634-3638 ◽  
Author(s):  
Naomi Shibasaki-Kitakawa ◽  
Takahiro Tsuji ◽  
Kouhei Chida ◽  
Masaki Kubo ◽  
Toshikuni Yonemoto

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