scholarly journals STUDIES ON THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM : STUDIES ON HISTOLOGICAL CHANGES IN ADRENAL AND RENAL TISSUE; A FOLLOW-UP STUDY OF POSTOPERATIVE BLOOD PRESSURE IN PRIMARY AND IDIOPATHIC ALDOSTERONISM

1972 ◽  
Vol 36 (2) ◽  
pp. 167-185 ◽  
Author(s):  
AKIO IMADA
Keyword(s):  
Blood Pressure ◽  
Renal Tissue ◽  
Histological Changes ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Follow Up Study

Abstract 12607: Renin Angiotensin Aldosterone System Inhibition Prevents the Arterial Stiffness Elevation Resulting in the Amelioration of Inappropriate Cardiovascular Response During Exercise in Patients With Hypertension

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Kanae Yabu ◽  
Takashi Masuda ◽  
Misao Ogura ◽  
Ryosuke Shimizu ◽  
Daisuke Kamekawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Exercise Test ◽  
Cardiovascular Response ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Before And After

Introduction: Patients with hypertension (HT) are known to show an increased activity of renin-angiotensin-aldosterone system (RAAS) secondary to sympathetic hyperactivity. The RAAS hyperactivity was reported to induce vascular endothelial dysfunction and elevated functional arterial stiffness resulting in an inappropriate cardiovascular response during exercise such as an excessive blood pressure (BP) elevation. This study investigated whether a long-term RAAS inhibition ameliorated the inappropriate cardiovascular response during exercise in HT patients. Methods: Eighty HT patients (64±14 years, 48 males) were divided into two groups based on antihypertensives: angiotensin II receptor blocker (ARB) group and L-type calcium channel blocker (CCB) group. Patients were followed up for one year, after their BP was controlled below 140/90 mmHg. Patients received a cycle ergometer test, and blood examination before and after the follow-up period. We determined systolic blood pressure (SBP) elevation during the exercise test as the change from baseline SBP to peak SBP (ΔSBP). We assessed the changes in plasma renin, aldosterone, noradrenaline (NORA) and adrenaline (ADRN), and brachial-ankle pulse wave velocity (PWV) before and after the exercise test (ΔNORA and ΔADRN as sympathetic activity parameters and ΔPWV as a functional arterial stiffness). Results: ΔSBP after the follow-up period was significantly lower in the ARB group than in the CCB group (P<0.001). ΔADRN and ΔPWV increased significantly after the follow-up period in the CCB group as compared with baseline assessment (P<0.05, respectively) despite no significant changes in the ARB group. Those after the follow-up period were significantly lower in the ARB group than in CCB group (P<0.05, P<0.001). Conclusions: RAAS inhibition prevented the arterial stiffness elevation resulting in the amelioration of inappropriate cardiovascular response during exercise in HT patients.

Polymorphisms in genes involved in inflammation, the NF-kB pathway and the renin-angiotensin-aldosterone system are associated with the risk of osteoporotic fracture. The Hortega Follow-up Study

Bone ◽  
2020 ◽  
Vol 138 ◽  
pp. 115477
Author(s):  
Ricardo Usategui-Martín ◽  
Verónica Lendinez-Tortajada ◽  
José Luis Pérez-Castrillón ◽  
Laisa Briongos-Figuero ◽  
Jesica Abadía-Otero ◽  
...  
Keyword(s):  
Osteoporotic Fracture ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Follow Up Study

scholarly journals Effect of captopril on blood pressure and renin-angiotensin-aldosterone system in hypertensive patients on hemodialysis.

1982 ◽  
Vol 137 (1) ◽  
pp. 21-31 ◽  
Author(s):  
HIROSHI KANEDA ◽  
TOYOAKI MURATA ◽  
JUN MATSUMOTO ◽  
TAKAKICHI MAETA ◽  
KOZO SHITOMI ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renin Angiotensin Aldosterone System ◽  
Hypertensive Patients ◽  
Renin Angiotensin

scholarly journals Tactics of antihypertensive therapy during COVID-19 pandemic

2021 ◽  
Vol 93 (9) ◽  
pp. 1125-1131
Author(s):  
Valery I. Podzolkov ◽  
Anna Е. Bragina ◽  
Yulia N. Rodionova ◽  
Galina I. Bragina ◽  
Ekaterina E. Bykova
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Diseases ◽  
Arterial Hypertension ◽  
Ace Inhibitor ◽  
Fixed Combination ◽  
Significant Risk ◽  
Effective Control ◽  
Combination Drug ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin

Results of foreign and Russian studies indicate a higher mortality rate of patients with concomitant cardiovascular diseases (CVD) due to the new coronavirus infection COVID-19. It has been proven that arterial hypertension, as one of the significant risk factors for the development of concomitant cardiovascular diseases, is associated with a more severe prognosis of COVID-19. This article presents the results of modern studies and large meta-analyzes of necessity and safety of the use of blockers of the renin-angiotensin-aldosterone system in patients with arterial hypertension and COVID-19. The data of studies show that an angiotensin-converting enzyme inhibitor (ACE inhibitor) and a thiazide-like diuretic is a pathogenetically rational combination. It realizes various ways of lowering blood pressure by reducing the activity of the renin-angiotensin-aldosterone system, which is achieved by using an ACE inhibitor, and natriuresis due to diuretics. As an example, a highly effective fixed combination of drugs is considered, characterized by good tolerance, which consists of an ACE inhibitor lisinopril and a thiazide-like diuretic indapamide of prolonged action. The authors expressed the opinion that the appointment of the fixed combination drug Diroton Plus (Gedeon Richter) will contribute to effective control of blood pressure and organoprotection in conditions of increased thrombogenic and prooxidative potential, characteristic of COVID-19 both in the acute stage and within the post-COVID Syndrome.

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