scholarly journals Negative regulatory mechanism of phospholipase C signaling triggered by G protein—coupled receptor

2009 ◽  
Vol 134 (5) ◽  
pp. 254-258 ◽  
Author(s):  
Isao Matsuoka ◽  
Masaaki Ito
Keyword(s):  
Phospholipase C ◽  
G Protein ◽  
Regulatory Mechanism ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Negative Regulatory Mechanism

scholarly journals Cell Density Sensing Mediated by a G Protein-coupled Receptor Activating Phospholipase C

1998 ◽  
Vol 273 (14) ◽  
pp. 8161-8168 ◽  
Author(s):  
Derrick T. Brazill ◽  
David F. Lindsey ◽  
John D. Bishop ◽  
Richard H. Gomer
Keyword(s):  
Phospholipase C ◽  
G Protein ◽  
Cell Density ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, G q and phospholipase C  in a signalling complex

2011 ◽  
Vol 124 (19) ◽  
pp. 3292-3304 ◽  
Author(s):  
A. Cartier ◽  
A. Parent ◽  
P. Labrecque ◽  
G. Laroche ◽  
J.-L. Parent
Keyword(s):  
Phospholipase C ◽  
G Protein ◽  
Scaffold Protein ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals G Protein-coupled Receptor-induced Sensitization of Phospholipase C Stimulation by Receptor Tyrosine Kinases

2000 ◽  
Vol 275 (42) ◽  
pp. 32603-32610 ◽  
Author(s):  
Martina Schmidt ◽  
Markus Frings ◽  
Marie-Luise Mono ◽  
Yuanjian Guo ◽  
Paschal A. Oude Weernink ◽  
...  
Keyword(s):  
Phospholipase C ◽  
G Protein ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Phospholipase C  is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation

2007 ◽  
Vol 104 (39) ◽  
pp. 15543-15548 ◽  
Author(s):  
S. Citro ◽  
S. Malik ◽  
E. A. Oestreich ◽  
J. Radeff-Huang ◽  
G. G. Kelley ◽  
...  
Keyword(s):  
Phospholipase C ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Astrocyte Proliferation ◽  
G Protein Coupled

scholarly journals Eliminating phosphorylation sites of the parathyroid hormone receptor type 1 differentially affects stimulation of phospholipase C and receptor internalization

2008 ◽  
Vol 295 (3) ◽  
pp. E665-E671 ◽  
Author(s):  
Susanne U. Miedlich ◽  
Abdul B. Abou-Samra
Keyword(s):  
Parathyroid Hormone ◽  
Phospholipase C ◽  
G Protein ◽  
Phosphorylation Site ◽  
Receptor Internalization ◽  
Phosphorylation Sites ◽  
G Protein Coupled Receptor ◽  
Parathyroid Hormone Receptor ◽  
Direct Binding ◽  
G Protein Coupled

The parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor (PTH1R) belongs to family B of seven-transmembrane-spanning receptors and is activated by PTH and PTHrP. Upon PTH stimulation, the rat PTH1R becomes phosphorylated at seven serine residues. Elimination of all PTH1R phosphorylation sites results in prolonged cAMP accumulation and impaired internalization in stably transfected LLC-PK1 cells. The present study explores the role of individual PTH1R phosphorylation sites in PTH1R signaling through phospholipase C, agonist-dependent receptor internalization, and regulation by G protein-coupled receptor kinases. By means of transiently transfected COS-7 cells, we demonstrate that the phosphorylation-deficient (pd) PTH1R confers dramatically enhanced coupling to Gq/11 proteins upon PTH stimulation predominantly caused by elimination of Ser491/492/493, Ser501, or Ser504. Reportedly, impaired internalization of the pd PTH1R, however, is not dependent on a specific phosphorylation site. In addition, we show that G protein-coupled receptor kinase 2 interferes with pd PTH1R signaling to Gq/11 proteins at least partially by direct binding to Gq/11 proteins.

The viral G protein-coupled receptor ORF74 unmasks phospholipase C signaling of the receptor tyrosine kinase IGF-1R

2016 ◽  
Vol 28 (6) ◽  
pp. 595-605 ◽  
Author(s):  
Sabrina M. de Munnik ◽  
Rosan van der Lee ◽  
Daniëlle M. Velders ◽  
Jody van Offenbeek ◽  
Laura Smits-de Vries ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Phospholipase C ◽  
G Protein ◽  
Receptor Tyrosine Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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