Should Older Patients Be Selectively Referred to High-Volume Centers for Abdominal Aortic Surgery?

Vascular ◽  
2004 ◽  
Vol 12 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Justin B. Dimick ◽  
Peter J. Pronovost ◽  
John A. Cowan ◽  
Reid M. Wainess ◽  
Gilbert R. Upchurch

The objective of the current study was to determine the effect of hospital volume on outcomes of abdominal aortic surgery for patients older than and younger than 65 years. In order to perform this investigation, information on all adult patients who underwent abdominal aortic surgery in Maryland from 1994 to 1996 ( N = 2,987 patients) in 45 acute care hospitals was obtained. Hospitals were designated as low (< 20/year), medium (20 to 36/year), or high (> 36/year) volume according to the annual number of procedures performed. The relationship of hospital volume and mortality was determined for patients less than or greater than 65 years old. Two separate multiple logistic regression models were used to adjust for patient case-mix in each age category. Of the 2,987 patients, 2,067 (69%) were older than 65 years and 920 (31%) were younger. The crude in-hospital mortality rates according to hospital volume were 2.7% (low), 2.1% (medium), and 2.7% (high) for patients younger than 65 years old ( p = .8). For patients older than 65 years, in-hospital mortality rates were 11.9% (low), 9.9% (medium), and 6.9% (high) ( p = .005). After adjusting for patient case-mix in a multivariate analysis, high hospital volume was associated with a decreased risk of in-hospital mortality for patients older than 65 years (OR 0.57; 95% CI 0.37 to 0.86; p = .008) but not for patients under 65 years old. In conclusion, hospital volume was associated with decreased in-hospital mortality after abdominal aortic surgery only for patients greater than 65 years old. Because of this differential effect, targeting elderly patients for regionalization would achieve most potentially avoidable deaths for this common high-risk surgical procedure.

2017 ◽  
Vol 66 (2) ◽  
pp. 404-412 ◽  
Author(s):  
Eric B. Rosero ◽  
Girish P. Joshi ◽  
Abu Minhajuddin ◽  
Carlos H. Timaran ◽  
J. Gregory Modrall

Vascular ◽  
2003 ◽  
Vol 12 (01) ◽  
pp. 51 ◽  
Author(s):  
Justin B. Dimick ◽  
Peter J. Pronovost ◽  
John A. Cowan ◽  
Reid M. Wainess ◽  
Gilbert R. Upchurch

Author(s):  
Alexander Gombert ◽  
Mohammad Barbati ◽  
Drosos Kotelis ◽  
Tim-Philipp Simon ◽  
Thomas Breuer ◽  
...  

Abstract OBJECTIVES Endovascular and open thoraco-abdominal aortic aneurysm (TAAA) repair is associated with specific complications. Circulating dipeptidyl peptidase 3 (cDPP3) is a novel biomarker that shows a strong association with organ failure which has not been assessed in surgical settings. Therefore, the objective of this study was to assess the prognostic capabilities of cDPP3 for predicting patient survival and organ failure following open and endovascular TAAA repair. METHODS Thirty-three patients undergoing TAAA repair were assessed in this prospective observational single-centre study. cDPP3 levels were serially measured perioperatively until 72 h after admission to the intensive care unit (ICU). In-hospital mortality and any organ failure were the clinical end points. RESULTS Postoperative organ failure was detected in 17 patients (51.5%), and 6 patients died after surgery (18.2%). At 12 h after admission to the ICU, cDPP3 levels were significantly increased in patients who died or developed organ failure (P &lt; 0.001). cDPP3 levels after surgery demonstrated a remarkable predictive accuracy for in-hospital mortality [12 h area under the receiver operating characteristic curve (AUC): 0.907 (P &lt; 0.001), 24 h AUC: 0.815 (P = 0.016), 48 h AUC: 0.914 (P = 0.003)] and the development of organ failure [12 h AUC: 0.882 (P &lt; 0.001), 24 h AUC: 0.850 (P &lt; 0.001), 48 h AUC: 0.846 (P &lt; 0.001)]. Additionally, a significant correlation between cDPP3, the sequential organ failure assessment score and procalcitonin, C-reactive protein and interleukin-6 levels (P &lt; 0.001, P &lt; 0.001, P = 0.011, P = 0.007, respectively) based on all available measurements and time points was observed. CONCLUSIONS The present findings highlight the role of cDPP3 as an early, highly specific postoperative biomarker for prediction of in-hospital mortality and organ failure after TAAA repair.


2001 ◽  
Vol 88 (5) ◽  
pp. 687-692 ◽  
Author(s):  
P. J. M. Bayly ◽  
J. N. S. Matthews ◽  
P. M. Dobson ◽  
M. L. Price ◽  
D. G. Thomas

2021 ◽  
Vol 74 (3) ◽  
pp. e124
Author(s):  
Ambar Mehta ◽  
Priya Patel ◽  
Thomas F. O'Donnell ◽  
Karan Garg ◽  
Jeffrey J. Siracuse ◽  
...  

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