Coexpression of platelet-derived growth factor receptor alpha and fetal liver kinase 1 enhances cardiogenic potential in embryonic stem cell differentiation in vitro

2007 ◽  
Vol 103 (5) ◽  
pp. 412-419 ◽  
Author(s):  
Hirokazu Hirata ◽  
Shin Kawamata ◽  
Yoshinobu Murakami ◽  
Kayoko Inoue ◽  
Ayako Nagahashi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Fetal Liver ◽  
Embryonic Stem ◽  
Growth Factor Receptor ◽  
Stem Cell Differentiation ◽  
Platelet Derived Growth Factor ◽  
Embryonic Stem Cell Differentiation ◽  
Factor Receptor Alpha

scholarly journals The dynamic emergence of GATA1 complexes identified in in vitro embryonic stem cell differentiation and in vivo mouse fetal liver

Haematologica ◽  
2019 ◽  
Vol 105 (7) ◽  
pp. 1802-1812
Author(s):  
Xiao Yu ◽  
Andrea Martella ◽  
Petros Kolovos ◽  
Mary Stevens ◽  
Ralph Stadhouders ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Embryonic Stem Cell ◽  
Fetal Liver ◽  
Embryonic Stem ◽  
Stem Cell Differentiation ◽  
Embryonic Stem Cell Differentiation

Developmentally regulated use of alternative promoters creates a novel platelet-derived growth factor receptor transcript in mouse teratocarcinoma and embryonic stem cells

1989 ◽  
Vol 9 (10) ◽  
pp. 4563-4567
Author(s):  
T H Vu ◽  
G R Martin ◽  
P Lee ◽  
D Mark ◽  
A Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Growth Factor ◽  
Short Form ◽  
Embryonic Stem ◽  
Growth Factor Receptor ◽  
Extracellular Domain ◽  
Platelet Derived Growth Factor ◽  
Alternative Promoters

Embryonal carcinoma and embryonic stem cells expressed a novel form of platelet-derived growth factor receptor mRNA which was approximately 1,100 base pairs shorter than the 5.3-kilobase (kb) transcript expressed in fibroblasts and other cell types. The 4.2-kb stem cell transcript was initiated within the genomic region immediately upstream of exon 6 of the 5.3-kb transcript and therefore lacked the first five exons, which encode much of the extracellular domain of the receptor expressed in fibroblasts. In stem cells, the short form was predominant, although both forms were present at low levels. Following differentiation in vitro, expression levels of the long form increased dramatically. These findings suggest that during early embryogenesis, a stem cell-specific promoter is used in a stage- and cell type-specific manner to express a form of the platelet-derived growth factor receptor that lacks much of the extracellular domain and may function independently of ligand.

scholarly journals Herpesvirus saimiri-based gene delivery vectors maintain heterologous expression throughout mouse embryonic stem cell differentiation in vitro

Gene Therapy ◽  
2000 ◽  
Vol 7 (6) ◽  
pp. 464-471 ◽  
Author(s):  
A J Stevenson ◽  
D Clarke ◽  
D M Meredith ◽  
S E Kinsey ◽  
A Whitehouse ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Heterologous Expression ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Stem Cell Differentiation ◽  
Herpesvirus Saimiri ◽  
Embryonic Stem Cell Differentiation ◽  
Gene Delivery Vectors

scholarly journals Analysis of Mitochondrial Function and Localisation during Human Embryonic Stem Cell Differentiation In Vitro

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52214 ◽  
Author(s):  
Andrew B. J. Prowse ◽  
Fenny Chong ◽  
David A. Elliott ◽  
Andrew G. Elefanty ◽  
Edouard G. Stanley ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Embryonic Stem Cell ◽  
Mitochondrial Function ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Stem Cell Differentiation ◽  
Embryonic Stem Cell Differentiation

scholarly journals Developmentally regulated use of alternative promoters creates a novel platelet-derived growth factor receptor transcript in mouse teratocarcinoma and embryonic stem cells.

1989 ◽  
Vol 9 (10) ◽  
pp. 4563-4567 ◽  
Author(s):  
T H Vu ◽  
G R Martin ◽  
P Lee ◽  
D Mark ◽  
A Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Growth Factor ◽  
Short Form ◽  
Embryonic Stem ◽  
Growth Factor Receptor ◽  
Extracellular Domain ◽  
Platelet Derived Growth Factor ◽  
Alternative Promoters

Embryonal carcinoma and embryonic stem cells expressed a novel form of platelet-derived growth factor receptor mRNA which was approximately 1,100 base pairs shorter than the 5.3-kilobase (kb) transcript expressed in fibroblasts and other cell types. The 4.2-kb stem cell transcript was initiated within the genomic region immediately upstream of exon 6 of the 5.3-kb transcript and therefore lacked the first five exons, which encode much of the extracellular domain of the receptor expressed in fibroblasts. In stem cells, the short form was predominant, although both forms were present at low levels. Following differentiation in vitro, expression levels of the long form increased dramatically. These findings suggest that during early embryogenesis, a stem cell-specific promoter is used in a stage- and cell type-specific manner to express a form of the platelet-derived growth factor receptor that lacks much of the extracellular domain and may function independently of ligand.

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