Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs)

2017 ◽  
Vol 60 (12) ◽  
pp. 5099-5119 ◽  
Author(s):  
Yanli Lu ◽  
Fei Mao ◽  
Xiaokang Li ◽  
Xinyu Zheng ◽  
Manjiong Wang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Stem Cell Factor ◽  
Gastrointestinal Stromal Tumors ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Dual Inhibitor ◽  
Stromal Tumors ◽  
Imatinib Resistant ◽  
Factor Receptor Alpha

Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors

2003 ◽  
Vol 125 (3) ◽  
pp. 660-667 ◽  
Author(s):  
Seiichi Hirota ◽  
Akiko Ohashi ◽  
Toshirou Nishida ◽  
Koji Isozaki ◽  
Kazuo Kinoshita ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gastrointestinal Stromal Tumors ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Gain Of Function ◽  
Stromal Tumors

scholarly journals A Malignant Gastrointestinal Stromal Tumor of the Gallbladder Immunoreactive for PDGFRA and Negative for CD 117 Antigen (c-KIT)

HPB Surgery ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Athanasios Petrou ◽  
Pari Alexandrou ◽  
Alexandros Papalambros ◽  
Angelica Saetta ◽  
Paraskevi Fragkou ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Growth Factor Receptor ◽  
Stromal Tumor ◽  
Platelet Derived Growth Factor ◽  
Stromal Tumors ◽  
Cd 117 ◽  
Factor Receptor Alpha ◽  
Malignant Gists ◽  
First Time

Gastrointestinal stromal tumors (GISTs) compose the largest category of well-recognized nonepithelial neoplasms of the gastrointestinal tract (GI). GISTs of the gallbladder are extremely rare tumors. Only four malignant, two benign and one GIST-like tumor of the gall bladder have ever been described. The four malignant GISTs were all positive for CD 117 antigen (c-kit). We present for the first time a malignant gastrointestinal stromal tumor of the gallbladder, immunoreactive for platelet-derived growth factor receptor alpha (PDGFRA) and negative for CD 117 antigen (c-KIT).

scholarly journals Gastrointestinal Stromal Tumors: Molecular Mechanisms and Targeted Therapies

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Erinn Downs-Kelly ◽  
Brian P. Rubin
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Molecular Mechanisms ◽  
Kinase Inhibitors ◽  
Growth Factor Receptor ◽  
Clinicopathological Features ◽  
Platelet Derived Growth Factor ◽  
Clinical Behavior ◽  
Stromal Tumors ◽  
Mesenchymal Neoplasms ◽  
Factor Receptor Alpha

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and are diverse not only in their clinical behavior but also in their histologic appearance. GISTs are insensitive to conventional sarcoma chemotherapy and radiation. However GISTs are sensitive to small-molecule tyrosine kinase inhibitors as 85–90% of GISTs have KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutations, which drive tumorigenesis. This review will briefly touch on the clinicopathological features of GIST, while the majority of the review will focus on the clinical and treatment ramifications of KIT and PDGFRA mutations found in GIST.

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