scholarly journals More than Meets the Eye: Bacteremic Pneumococcal Pneumonia as the Initial Presentation of Multiple Myeloma

2021 ◽  
Vol 22 ◽  
Author(s):  
Jonas Jautz ◽  
Eliska Potlukova ◽  
Franziska Zeeh ◽  
Michael Osthoff
Keyword(s):  
Multiple Myeloma ◽  
Pneumococcal Pneumonia ◽  
Initial Presentation ◽  
Bacteremic Pneumococcal Pneumonia

scholarly journals 1475. Impact of a Routine Infant PCV Program on the Serotype Distribution of Episodes of Invasive Pneumococcal Disease (IPD) and Non-bacteremic Pneumococcal Pneumonia in Adults

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S739-S739
Author(s):  
Allison McGeer
Keyword(s):  
Pneumococcal Pneumonia ◽  
Herd Immunity ◽  
Panel Member ◽  
Population Based ◽  
Review Panel ◽  
Vaccine Type ◽  
Bacteremic Pneumococcal Pneumonia ◽  
Type Strains ◽  
Routine Infant ◽  
Research Grant

Abstract Background Herd immunity from pediatric pneumococcal conjugate vaccine (PCV) programs has resulted in substantial reductions in IPD due to PCV serotypes (ST). We assessed whether similar changes in ST distribution occur in non-bacteremic pneumococcal pneumonia (NBPP). Methods The Toronto Invasive Bacterial Diseases Network performs population-based surveillance for IPD and hospitalized, culture-confirmed NBPP in Toronto/Peel Region, Canada (Pop 4.5M). Patient data are collected by interview/chart review; illness associated with respiratory isolates is categorized using Musher criteria. Results Since 2002, 6627 episodes of IPD, and 7323 non-bacteremic episodes with a respiratory isolate of S. pneumoniae (2180 meeting modified Musher criteria for NBPP) have occurred in adults. Distributions of vaccine-type serotypes in IPD and NBPP pre-PCV7 (2002-2004), post-PCV7 (2006-2009) and late post-PCV13 (2014-2019) are shown in the Figure. There were no significant changes in distribution of vaccine serotype groups from 2014-2019 in IPD or NBPP. From 2014-2019, serotypes included in PCV13 and PCV20 were associated with 33% and 59% of IPD cases, and 29% and 49% of NBPP cases in adults.. Figure. distribution of serotype groups included in different pneumococcal vaccines in cases of IPD and non-bacteremic pneumonia Conclusion Eight years post routine infant PCV13 implementation, PCV13 type IPD and NBPP persists in adults. The distribution of vaccine-type strains is similar in IPD and NBPP; although non-vaccine-type strains are more common in NBPP. Disclosures Allison McGeer, MD, FRCPC, GlaxoSmithKline (Advisor or Review Panel member, Research Grant or Support)Merck (Advisor or Review Panel member, Research Grant or Support)Pfizer (Research Grant or Support)

scholarly journals Chronic Lymphocytic Leukemia: A Rare Cause of Pathological Fracture of the Femur

2017 ◽  
Vol 5 (4) ◽  
pp. 232470961773513 ◽  
Author(s):  
Parita Soni ◽  
Nidhi Aggarwal ◽  
Anand Rai ◽  
Vivek Kumar ◽  
Kamholz Stephan ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Chronic Lymphocytic Leukemia ◽  
Endotracheal Intubation ◽  
Pathological Fracture ◽  
The United States ◽  
Left Knee ◽  
Lymphocytic Leukemia ◽  
Initial Presentation ◽  
Richter’S Transformation ◽  
Richter's Transformation

The incidence rate of chronic lymphocytic leukemia (CLL) in the United States is approximately 0.005%; men are at slightly higher risk than women. Bony involvement or pathological fracture rarely occurs in CLL, and it may be the initial presentation. An 85-year-old woman presented with acute respiratory failure secondary to pneumonia. Symptomatology included dyspnea. She was found to have pathological fracture of the femur caused by CLL. The diagnosis of CLL had been made 6 years previously, but the patient had refused therapy. On admission, the patient required endotracheal intubation, mechanical ventilation, and admission to the medical intensive care unit. Endotracheal intubation extubation was successful after 48 hours. The patient then complained of severe left knee pain. Bone radiograph and femoral computed tomography scan revealed acute pathological fracture of the left distal femur. There was no history of trauma. The fracture was stabilized with extension lock splint. Pathological fracture in patients with CLL is associated with hypercalcemia, Richter’s transformation, or multiple myeloma. This patient exemplifies the fact that pathological fracture can be caused by CLL in the absence of hypercalcemia, Richter’s transformation, or multiple myeloma and can be the initial presentation of CLL.

scholarly journals Macrolide Resistance in Adults with Bacteremic Pneumococcal Pneumonia

2006 ◽  
Vol 12 (8) ◽  
pp. 1223-1230 ◽  
Author(s):  
Joshua P. Metlay ◽  
Neil O. Fishman ◽  
Marshall M. Joffe ◽  
Michael J. Kallan ◽  
Jesse L. Chittams ◽  
...  
Keyword(s):  
Pneumococcal Pneumonia ◽  
Macrolide Resistance ◽  
Bacteremic Pneumococcal Pneumonia

Addition of a macrolide to a ß-lactam in bacteremic pneumococcal pneumonia

2006 ◽  
Vol 25 (8) ◽  
pp. 518-521 ◽  
Author(s):  
R. Dwyer ◽  
Å. Örtqvist ◽  
E. Aufwerber ◽  
B. Henriques Normark ◽  
T.J. Marrie ◽  
...  
Keyword(s):  
Pneumococcal Pneumonia ◽  
Bacteremic Pneumococcal Pneumonia

scholarly journals Bilateral renal infiltration as the initial presentation of multiple myeloma

2014 ◽  
Vol 167 (1) ◽  
pp. 2-2
Author(s):  
Yasushi Kubota ◽  
Miwako Matsuzaki ◽  
Shinya Kimura
Keyword(s):  
Multiple Myeloma ◽  
Initial Presentation

scholarly journals Abducens Nerve Palsy as Initial Presentation of Multiple Myeloma and Intracranial Plasmacytoma

2018 ◽  
Vol 7 (9) ◽  
pp. 253
Author(s):  
Elochukwu Ibekwe ◽  
Neil Horsley ◽  
Lan Jiang ◽  
Nadine-Stella Achenjang ◽  
Azubuogu Anudu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Multiple Myeloma ◽  
Nervous System ◽  
Case Report ◽  
Nerve Palsy ◽  
Abducens Nerve ◽  
Initial Presentation ◽  
Solitary Plasmacytoma ◽  
Cns Involvement ◽  
The Right

Central Nervous System (CNS) involvement in multiple myeloma and/or multifocal solitary plasmacytoma is rare. Although they are unique entities, multiple myeloma (MM) and plasmacytoma represent a spectrum of plasma cell neoplastic diseases that can sometimes occur concurrently. Plasmacytomas very often present as late-stage sequelae of MM. In this case report, we report a 53-year-old female presenting with right abducens cranial nerve (CN) VI palsy as an initial presentation secondary to lesion of the right clivus.

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