Faculty Opinions recommendation of Current Smoking and Reduced Mortality in Bacteremic Pneumococcal Pneumonia: A Population-Based Cohort Study.

2016 ◽  
Author(s):  
Charles Feldman
Keyword(s):  
Cohort Study ◽  
Pneumococcal Pneumonia ◽  
Population Based ◽  
Current Smoking ◽  
Bacteremic Pneumococcal Pneumonia

scholarly journals 1475. Impact of a Routine Infant PCV Program on the Serotype Distribution of Episodes of Invasive Pneumococcal Disease (IPD) and Non-bacteremic Pneumococcal Pneumonia in Adults

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S739-S739
Author(s):  
Allison McGeer
Keyword(s):  
Pneumococcal Pneumonia ◽  
Herd Immunity ◽  
Panel Member ◽  
Population Based ◽  
Review Panel ◽  
Vaccine Type ◽  
Bacteremic Pneumococcal Pneumonia ◽  
Type Strains ◽  
Routine Infant ◽  
Research Grant

Abstract Background Herd immunity from pediatric pneumococcal conjugate vaccine (PCV) programs has resulted in substantial reductions in IPD due to PCV serotypes (ST). We assessed whether similar changes in ST distribution occur in non-bacteremic pneumococcal pneumonia (NBPP). Methods The Toronto Invasive Bacterial Diseases Network performs population-based surveillance for IPD and hospitalized, culture-confirmed NBPP in Toronto/Peel Region, Canada (Pop 4.5M). Patient data are collected by interview/chart review; illness associated with respiratory isolates is categorized using Musher criteria. Results Since 2002, 6627 episodes of IPD, and 7323 non-bacteremic episodes with a respiratory isolate of S. pneumoniae (2180 meeting modified Musher criteria for NBPP) have occurred in adults. Distributions of vaccine-type serotypes in IPD and NBPP pre-PCV7 (2002-2004), post-PCV7 (2006-2009) and late post-PCV13 (2014-2019) are shown in the Figure. There were no significant changes in distribution of vaccine serotype groups from 2014-2019 in IPD or NBPP. From 2014-2019, serotypes included in PCV13 and PCV20 were associated with 33% and 59% of IPD cases, and 29% and 49% of NBPP cases in adults.. Figure. distribution of serotype groups included in different pneumococcal vaccines in cases of IPD and non-bacteremic pneumonia Conclusion Eight years post routine infant PCV13 implementation, PCV13 type IPD and NBPP persists in adults. The distribution of vaccine-type strains is similar in IPD and NBPP; although non-vaccine-type strains are more common in NBPP. Disclosures Allison McGeer, MD, FRCPC, GlaxoSmithKline (Advisor or Review Panel member, Research Grant or Support)Merck (Advisor or Review Panel member, Research Grant or Support)Pfizer (Research Grant or Support)

Current Smoking and Reduced Mortality in Bacteremic Pneumococcal Pneumonia

CHEST Journal ◽  
2016 ◽  
Vol 150 (3) ◽  
pp. 652-660 ◽  
Author(s):  
Jessica A. Beatty ◽  
Sumit R. Majumdar ◽  
Gregory J. Tyrrell ◽  
Thomas J. Marrie ◽  
Dean T. Eurich
Keyword(s):  
Pneumococcal Pneumonia ◽  
Current Smoking ◽  
Bacteremic Pneumococcal Pneumonia

scholarly journals Empyema and bacteremic pneumococcal pneumonia in children under five years of age

2014 ◽  
Vol 40 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Maria Regina Alves Cardoso ◽  
Cristiana Maria Costa Nascimento-Carvalho ◽  
Fernando Ferrero ◽  
Eitan Naaman Berezin ◽  
Raul Ruvinsky ◽  
...  
Keyword(s):  
Cohort Study ◽  
Dominican Republic ◽  
Pneumococcal Pneumonia ◽  
Disease Duration ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Under Five ◽  
Leukocyte Counts ◽  
Bacteremic Pneumococcal Pneumonia ◽  
Prompt Diagnosis

We compared bacteremic pneumococcal pneumonia (BPP) and pneumococcal empyema (PE), in terms of clinical, radiological, and laboratory findings, in under-fives. A cross-sectional nested cohort study, involving under-fives (102 with PE and 128 with BPP), was conducted at 12 centers in Argentina, Brazil, and the Dominican Republic. Among those with PE, mean age was higher; disease duration was longer; and tachypnea, dyspnea, and high leukocyte counts were more common. Among those with BPP, fever and lethargy were more common. It seems that children with PE can be distinguished from those with BPP on the basis of clinical and laboratory findings. Because both conditions are associated with high rates of morbidity and mortality, prompt diagnosis is crucial.

Increased Lung Cancer Risk Among Patients with Pneumococcal Pneumonia: A Nationwide Population-Based Cohort Study

Lung ◽  
2013 ◽  
Vol 192 (1) ◽  
pp. 159-165 ◽  
Author(s):  
Te-Yu Lin ◽  
Wen-Yen Huang ◽  
Jung-Chung Lin ◽  
Cheng-Li Lin ◽  
Fung-Chang Sung ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Pneumococcal Pneumonia ◽  
Lung Cancer Risk ◽  
Population Based

Pneumococcal pneumonia and the risk of acute coronary syndrome: A population-based cohort study

2013 ◽  
Vol 168 (4) ◽  
pp. 4480-4481 ◽  
Author(s):  
Chun-Cheng Wang ◽  
Chiao-Ling Peng ◽  
Guei-Jane Wang ◽  
Fung-Chang Sung ◽  
Chia-Hung Kao
Keyword(s):  
Acute Coronary Syndrome ◽  
Cohort Study ◽  
Pneumococcal Pneumonia ◽  
Population Based ◽  
Coronary Syndrome

Plasma angiopoietin-like protein 2 levels and mortality risk among younger-old Japanese people: a population-based case-cohort study

2022 ◽  
Author(s):  
Wenjing Zhao ◽  
Jun Morinaga ◽  
Shigekazu Ukawa ◽  
Motoyoshi Endo ◽  
Hiroya Yamada ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Mortality ◽  
Caloric Intake ◽  
High Sensitivity ◽  
Population Based ◽  
Community Dwelling ◽  
Current Smoking ◽  
Protein Levels ◽  
Reactive Protein ◽  
Old Japanese

Abstract Aging is important medical and social problem. Excessive angiopoietin-like protein (ANGPTL)-2 signaling causes chronic tissue inflammation, promoting development and progression of aging-related diseases. Moreover, circulating ANGPTL2 levels reportedly predict risk of some aging-related diseases and subsequent death. However, there are as yet no reports of whether circulating ANGPTL2 levels predict vital prognosis in younger-old, community-dwelling populations. This study investigated associations between plasma ANGPTL2 levels and all-cause and specific-cause mortality in this population. The case-cohort study was abstracted from an on-going, age-specific prospective cohort study: the New Integrated Suburban Seniority Investigation Project. This project enrolled 3073 participants aged 64 years at the beginning of the investigation from 1996 through 2005. A sub-cohort of 714 randomly sampled participants plus 387 cases representing deceased participants followed through 2015 underwent survival analysis. Plasma ANGPTL2 concentrations were positively associated with >80% and 100% higher risk of all-cause mortality and cancer mortality, respectively, after adjustment for gender, smoking, alcohol consumption, walking time, sleep duration, caloric intake, medical status, disease history, BMI, and triglyceride, creatinine, uric acid, and high sensitivity C-reactive protein levels. More robust association between ANGPTL2 levels and all-cause and cancer mortality was seen in subjects with either frailties or with lifestyles of heavier drinking or current smoking. Elevated plasma ANGPTL2 levels are associated with high all-cause and cancer mortality in a community-dwelling sample of younger-old adults. These findings expand our knowledge of human aging and associated diseases.

scholarly journals Age dependent associations of risk factors with heart failure: pooled population based cohort study

BMJ ◽  
2021 ◽  
pp. n461
Author(s):  
Jasper Tromp ◽  
Samantha M A Paniagua ◽  
Emily S Lau ◽  
Norrina B Allen ◽  
Michael J Blaha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Cohort Study ◽  
Absolute Risk ◽  
Population Based ◽  
Attributable Risk ◽  
Smoking History ◽  
Middle Aged ◽  
Current Smoking ◽  
Incident Heart Failure

Abstract Objective To assess age differences in risk factors for incident heart failure in the general population. Design Pooled population based cohort study. Setting Framingham Heart Study, Prevention of Renal and Vascular End-stage Disease Study, and Multi-Ethnic Study of Atherosclerosis. Participants 24 675 participants without a history of heart failure stratified by age into young (<55 years; n=11 599), middle aged (55-64 years; n=5587), old (65-74 years; n=5190), and elderly (≥75 years; n=2299) individuals. Main outcome measure Incident heart failure. Results Over a median follow-up of 12.7 years, 138/11 599 (1%), 293/5587 (5%), 538/5190 (10%), and 412/2299 (18%) of young, middle aged, old, and elderly participants, respectively, developed heart failure. In young participants, 32% (n=44) of heart failure cases were classified as heart failure with preserved ejection fraction compared with 43% (n=179) in elderly participants. Risk factors including hypertension, diabetes, current smoking history, and previous myocardial infarction conferred greater relative risk in younger compared with older participants (P for interaction <0.05 for all). For example, hypertension was associated with a threefold increase in risk of future heart failure in young participants (hazard ratio 3.02, 95% confidence interval 2.10 to 4.34; P<0.001) compared with a 1.4-fold risk in elderly participants (1.43, 1.13 to 1.81; P=0.003). The absolute risk for developing heart failure was lower in younger than in older participants with and without risk factors. Importantly, known risk factors explained a greater proportion of overall population attributable risk for heart failure in young participants (75% v 53% in elderly participants), with better model performance (C index 0.79 v 0.64). Similarly, the population attributable risks of obesity (21% v 13%), hypertension (35% v 23%), diabetes (14% v 7%), and current smoking (32% v 1%) were higher in young compared with elderly participants. Conclusions Despite a lower incidence and absolute risk of heart failure among younger compared with older people, the stronger association and greater attributable risk of modifiable risk factors among young participants highlight the importance of preventive efforts across the adult life course.

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