scholarly journals Dose-dependent protection on cisplatin-induced ototoxicity – an electrophysiological study on the effect of three antioxidants in the Sprague-Dawley rat animal model

2011 ◽  
Vol 17 (8) ◽  
pp. BR179-BR186 ◽  
Author(s):  
Guiscardo Lorito ◽  
Stavros Hatzopoulos ◽  
Goran Laurell ◽  
Kathleen C.M. Campbell ◽  
Joseph Petruccelli ◽  
...  
Keyword(s):  
Animal Model ◽  
Electrophysiological Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Dose Dependent ◽  
Rat Animal Model

Heterotopic Ossification After Extremity Blast Amputation in a Sprague-Dawley Rat Animal Model

2011 ◽  
Vol 25 (8) ◽  
pp. 506-510 ◽  
Author(s):  
Oliver Tannous ◽  
Cullen Griffith ◽  
Robert V OʼToole ◽  
Vincent D Pellegrini
Keyword(s):  
Animal Model ◽  
Heterotopic Ossification ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Rat Animal Model

Ototoxic effects of cisplatin in a Sprague–Dawley rat animal model as revealed by ABR and transiently evoked otoacoustic emission measurements

2002 ◽  
Vol 170 (1-2) ◽  
pp. 70-82 ◽  
Author(s):  
Stavros Hatzopoulos ◽  
Joseph Petruccelli ◽  
Goran Laurell ◽  
Paul Avan ◽  
Mario Finesso ◽  
...  
Keyword(s):  
Animal Model ◽  
Otoacoustic Emission ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Rat Animal Model

Effect of cholecystokinin and related peptides on jejunal transepithelial hexose transport in the Sprague-Dawley rat

1996 ◽  
Vol 271 (5) ◽  
pp. G755-G761 ◽  
Author(s):  
A. J. Hirsh ◽  
R. Tsang ◽  
S. Kammila ◽  
C. I. Cheeseman
Keyword(s):  
Dependent Manner ◽  
Hexose Transport ◽  
Sprague Dawley ◽  
Perfusion Technique ◽  
Sprague Dawley Rat ◽  
Luminal Perfusion ◽  
Dose Dependent ◽  
Krebs Buffer ◽  
Somatostatin 14

An in situ dual vascular and luminal perfusion technique was used to study the effect of cholecystokinin octapeptide (CCK-8) on the transport of hexoses by the jejunum of the Sprague-Dawley rat from the lumen to the vascular bed. The lumen of the jejunumwas perfused with hexoses in oxygenated Krebs buffer, while the superior mesenteric artery was infused with Krebs buffer containing Ficoll 70 as a plasma expander. CCK-8 (0.8–8 pM) in the vascular infusate selectively reduced hexose transport in a dose-dependent manner by 20–47%, although having no effect on L-glucose or L-leucine absorption. Vascular tetrodotoxin did not block CCK-8 inhibition, whereas a specific CCK-A receptor antagonist, lorglumide, did. The CCK-B receptor agonist cholecystokinin tetrapeptide had a small effect on hexose absorption, whereas somatostatin-14 and -28 had no effect. These results suggest that cholecystokinin can decrease intestinal absorption of hexoses in the small intestine, acting via CCK-A-type receptors.

Vascular effects of 17 beta-estradiol in male Sprague-Dawley rats

1994 ◽  
Vol 266 (3) ◽  
pp. H967-H973 ◽  
Author(s):  
J. Shan ◽  
L. M. Resnick ◽  
Q. Y. Liu ◽  
X. C. Wu ◽  
M. Barbagallo ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Dependent Manner ◽  
Rat Tail Artery ◽  
Sprague Dawley ◽  
Tail Artery ◽  
Sprague Dawley Rat ◽  
Sprague Dawley Rats ◽  
Voltage Dependent ◽  
Dose Dependent ◽  
Rat Tail

Bolus intravenous injections of 100 micrograms/kg 17 beta-estradiol significantly decreased the pressor responses to norepinephrine (NE; 0.3 microgram/kg) at the fourth, fifth, and sixth hour in anesthetized male Sprague-Dawley rats. At doses of 10(-6) to 3 x 10(-5) M, 17 beta-estradiol relaxed the sustained phase of contraction in male Sprague-Dawley rat tail artery helical strips precontracted in vitro by [Arg8]vasopressin (AVP), KCl, or NE. The effect was dose dependent. At doses of 3 x 10(-6) to 3 x 10(-5) M, it also decreased the initial phase of tension generation and extracellular Ca(2+)-dependent vasoconstriction induced by NE, AVP, or KCl in a dose-dependent manner in male Sprague-Dawley rat tail artery helical strips. 17 beta-Estradiol (2 x 10(-8) to 2 x 10(-6) M) decreased the voltage-dependent inward Ca2+ current and the intracellular free Ca2+ concentration ([Ca2+]i) increment induced by 15 mM KCl in a dose-dependent manner (3.6 x 10(-8) to 3.6 x 10(-6) M) in vascular smooth muscle cells (VSMC) isolated from male Sprague-Dawley rat tail arteries. We suggest that, at pharmacological doses, estrogen has a direct vasodilating effect on the rat tail artery that is mediated by its inhibitory effect on Ca2+ influx through voltage-dependent Ca2+ channels. The inhibitory effect of estrogen on the pressor responses to NE or AVP may be correlated with its modulation of VSMC [Ca2+]i through its actions on membrane Ca2+ channels.

Lateral Approach to the Lumbar Spine of Sprague Dawley Rat: Development of a Novel Animal Model for Spine Surgery

2019 ◽  
Vol 2 (2) ◽  
pp. 134
Author(s):  
HarvinderSingh Chhabra ◽  
ShaktiA Goel ◽  
Puja Nagpal ◽  
Perumal Nagarajan ◽  
AK Panda
Keyword(s):  
Animal Model ◽  
Lumbar Spine ◽  
Spine Surgery ◽  
Lateral Approach ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Rat Development

An Animal Model Based on the Sprague Dawley Rat for the Evaluation of Ototoxicity

1999 ◽  
Vol 884 (1) ◽  
pp. 85-98 ◽  
Author(s):  
A. MARTINI ◽  
S. HATZOPOULOS ◽  
R. RUBINI ◽  
M. DI STEFANO ◽  
A. ALBERTIN ◽  
...  
Keyword(s):  
Animal Model ◽  
Sprague Dawley ◽  
Model Based ◽  
Sprague Dawley Rat

Ultrastructural investigation of spontaneous pituitary gonadotroph cell adenomas in aging Sprague-Dawley rats

1983 ◽  
Vol 41 ◽  
pp. 702-703
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
Epoxy Resin ◽  
Immunoelectron Microscopy ◽  
Tumor Type ◽  
Gonadal Function ◽  
Sprague Dawley ◽  
Male And Female ◽  
Reticulin Fibers ◽  
Sprague Dawley Rats

Gonadotroph cell adenomas of the pituitary are infrequent in human patients and are not invariably associated with altered gonadal function. To date, no animal model of this tumor type exists. Herein, we describe spontaneous gonadotroph cell adenomas in old male and female Sprague-Dawley rats by histology, immunocytology and electron microscopy.The material consisted of the pituitaries of 27 male and 38 female Sprague Dawley rats, all 26 months of age or older, removed at routine autopsy. Sections of formal in-fixed, paraffin-embedded tissue were stained with hematoxylin-phloxine-saffron (HPS), the PAS method and the Gordon-Sweet technique for the demonstration of reticulin fibers. For immunostaining, sections were exposed to anti-rat β-LH, anti-ratβ-TSH, anti-rat PRL, anti-rat GH and anti-rat ACTH 1-39. For electron microscopy, tissue was fixed in 2.5% glutaraldehyde, postfixed in 1% OsO4 and embedded in epoxy-resin. Tissue fixed in 10% formalin, embedded in epoxy resin without osmification, was used for immunoelectron microscopy.

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