scholarly journals Distribution of a Human Brain Carboxypeptidase B Capable of Cleaving .BETA.-Amyloid Precursor Protein (APP) in Normal and Aizheimer's Diseased Brain.

2001 ◽  
Vol 34 (4) ◽  
pp. 275-283
Author(s):  
Kyoko Itoh ◽  
Akira Matsumoto
Keyword(s):  
Amyloid Precursor Protein ◽  
Human Brain ◽  
Beta Amyloid ◽  
Precursor Protein ◽  
Carboxypeptidase B

Expression of human brain carboxypeptidase B, a possible cleaving enzyme for β-amyloid precursor protein, in peripheral fluids

2001 ◽  
Vol 39 (3) ◽  
pp. 313-317 ◽  
Author(s):  
Akira Matsumoto ◽  
Kenjiro Motozaki ◽  
Tsuneyoshi Seki ◽  
Ryohei Sasaki ◽  
Tetsuya Kawabe
Keyword(s):  
Amyloid Precursor Protein ◽  
Human Brain ◽  
Precursor Protein ◽  
Carboxypeptidase B ◽  
Β Amyloid

scholarly journals The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein.

1990 ◽  
Vol 265 (16) ◽  
pp. 8983-8985 ◽  
Author(s):  
S Sinha ◽  
H F Dovey ◽  
P Seubert ◽  
P J Ward ◽  
R W Blacher ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Beta Amyloid ◽  
Precursor Protein

scholarly journals Secretion of beta-amyloid precursor protein involves multiple cleavage sites.

1994 ◽  
Vol 269 (1) ◽  
pp. 627-632
Author(s):  
Z. Zhong ◽  
J. Higaki ◽  
K. Murakami ◽  
Y. Wang ◽  
R. Catalano ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Beta Amyloid ◽  
Precursor Protein ◽  
Cleavage Sites

Understanding the structural requirements of cyclic sulfone hydroxyethylamines as hBACE1 inhibitors against Aβ plaques in Alzheimer's disease: a predictive QSAR approach

RSC Advances ◽  
2016 ◽  
Vol 6 (34) ◽  
pp. 28171-28186 ◽  
Author(s):  
Pravin Ambure ◽  
Kunal Roy
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Beta Amyloid ◽  
Precursor Protein ◽  
Structural Requirements ◽  
Amyloid Aβ

Beta (β)-site amyloid precursor protein cleaving enzyme 1 (BACE1) is one of the most important targets in Alzheimer's disease (AD), which is responsible for production and accumulation of beta amyloid (Aβ).

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