With excellent flame retardation and thermal insulation properties, SY self-temperature regulation and phase change energy-saving wall insulation material (the material) is composed of concrete and volcano perlite. At present, applied research of this material is not very thorough,especially under the condition of temperature variation, seasonal wind change in North China. In this paper, finite element analysis of external wall insulation layer of the Experimental Teaching Building in Taiyuan University of Science and Technology under negative wind pressure effect is performed. The negative wind load calculated is applied to the surface of the thermal insulation layer as uniform load, and the results show that the material used in the building which shorter than 80 meters in the Taiyuan area has no shedding or destruction under the negative air pressure. This material is safe and available.