The Expression of Inflammatory Cytokines in Liver Cirrhosis Rats Serum under the Condition of the Whole Liver Blood Flow Blocking

SummaryUsing their own modified method the authors simultaneously examined the blood clearances of 198Au colloid and 131I-Rose Bengal and determined the ratio1. in a group of 11 patients with severe liver cirrhosis, portal hypertension and portosystemic shunts, both before and after artificial portocaval anastomosis, and2. in two patients with thrombosis v. lienalis, excessive splenomegaly and extensive portosystemic shunts before and after splenectomy. Ad 1. In 6 patients 55%) a reduction of the effective liver blood flow occured due to the artificial portosystemic anastomosis; the average decrease was ~ 20%. In 7 patients a significant enlargement of the total splenosystemic flow was observed as a result of the artificial communication.Ad 2. In both patients an increase of the effective liver blood flow occured after splenectomy. The minimal preoperative splenosystemic flow was ~ 0.152 and ~ 0.089 of the circulating blood per minute (expressed by means of kAu).The authors discuss the significance of the kAu and kBR values as well as that of the ratio for the estimation of changes in hepatic and portal haemodynamics.

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Sonography, antipyrine clearance and liver blood flow in liver cirrhosis

Journal of Hepatology ◽

10.1016/s0168-8278(85)80409-8 ◽

1985 ◽

Vol 1 ◽

pp. S187

Keyword(s):

Blood Flow ◽

Liver Cirrhosis ◽

Liver Blood Flow ◽

Antipyrine Clearance

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Liver Blood Flow as a Major Determinant of the Clearance of Recombinant Human Tissue-Type Plasminogen Activator

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648385 ◽

1992 ◽

Vol 67 (01) ◽

pp. 083-087 ◽

Cited By ~ 44

Author(s):

A de Boer ◽

C Kluft ◽

J M Kroon ◽

F J Kasper ◽

H C Schoemaker ◽

...

Keyword(s):

Blood Flow ◽

Rat Liver ◽

Healthy Subjects ◽

Liver Blood Flow ◽

Major Determinant ◽

Tissue Type ◽

Perfused Rat Liver ◽

Liver Model ◽

Type Plasminogen Activator ◽

Proportional Change

SummaryThe influence of changes in liver blood flow on the clearance of rt-PA was studied both in healthy subjects and in a perfused rat liver model. Liver blood flow in healthy subjects was documented indirectly by the clearance of indocyanine green (ICG). Exercise reduced liver blood flow on average by 57% with a 95% confidence interval (95% Cl) ranging from 51% to 62% (n = 5) and increased plasma levels of rt-PA activity (after an i. v. infusion of 18 mg of rt-PA over 120 min) by 119% (95% Cl, 58% - 203%) and rt-PA antigen by 91% (95% Cl, 30% - 140%). In the perfused rat liver model it was shown that halving or doubling of the physiological flow rate of a perfusate, containing rt-PA caused a proportional change in the clearance of rt-PA, while the extraction of rt-PA by the liver remained similar. In conclusion, liver blood flow is a major determinant of the clearance of rt-PA. This may have important implications for dosage of rt-PA in patients with myocardial infarction.

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