The Effect of Continuous Nursing Intervention on Quality of Life in Patients with Type 2 Diabetic Retinopathy

Abstract Background and aims Painful polyneuropathy (PPN) is a disabling complication of diabetes. This study aims to determine its prevalence and relationship with Quality of Life (QoL) in a nationwide prospective cohort of incident recently diagnosed Danish type 2 diabetic patients. Methods We sent a detailed questionnaire on neuropathy, pain and QoL to 6726 patients prospectively enrolled from general practitioners and hospital specialist outpatient clinics into the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. Patients who reported pain in both feet and a score ≥3 on the Douleur Neuropathique (DN4) questionnaire were considered to have possible PPN. QoL and pain intensity were measured on a numeric rating scale (NRS, 0–10). The Michigan Neuropathy Screening Instrument (MNSI) was used to assess neuropathy. Results A total of 5371 (79.8%) returned a complete questionnaire. 848 (15.8%) recently diagnosed type 2 diabetic patients reported pain in both feet. Of the 619 patients with pain who completed the DN4 questionnaire, 404 (65.2%) had a DN4 score ≥ 3, corresponding to a prevalence in the total population of possible PPN of 10.3%. Mean pain intensity was 5.2 (SD 2.2) and 89% had a MNSI score ≥ 3. Patients with possible PPN had a substantially lower QoL score than those without PPN (median QoL score 6 versus 8 (p < 0.001)), also when correcting for MNSI score. Conclusions Ten percent of newly diagnosed type 2 diabetic patients in Denmark had possible PPN. Patients with PPN had lower QoL than patients without PPN.

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Analyzing the Role of DNA Hydroxymethylation in BDNF Gene in case of Type 2 Diabetic Retinopathy

International Journal for Research in Applied Science and Engineering Technology ◽

10.22214/ijraset.2019.11018 ◽

2019 ◽

Vol 7 (11) ◽

pp. 97-100

Author(s):

Anuradha Agrawal

Keyword(s):

Diabetic Retinopathy ◽

Bdnf Gene ◽

Dna Hydroxymethylation ◽

Type 2 Diabetic ◽

Type 2 Diabetic Retinopathy

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The Role of Hypertension and Dyslipidaemia in the Progression of Diabetic Retinopathy in Type 2 Diabetes

International Journal of Diabetes & Metabolic Disorders ◽

10.33140/ijdmd.04.04.01 ◽

2019 ◽

Vol 4 (4) ◽

Cited By ~ 1

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Diabetic Retinopathy ◽

Laser Photocoagulation ◽

Vitreoretinal Surgery ◽

Additional Burden

Despite the introduction of retinal laser photocoagulation and vitreoretinal surgery, diabetic retinopathy (DR) remains a significant source of sight disorders and blindness amongst individuals with Type 2 Diabetes Mellitus (T2DM) [1]. Visual impairment and blindness can add an additional burden to individuals with T2DM, thereby, affecting their quality of life and ability to self-manage their diabetes [2]. The number of people registered blind and those with moderate to severe sight complications due to DR rose from 0.2 million to 0.4 and 1.4 million to 2.6 million respectively between 1990 to 2015 [3].

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Elevation in Circulating Soluble CD40 Ligand Concentrations in Type 2 Diabetic Retinopathy and Association with its Severity

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/a-0647-6860 ◽

2018 ◽

Vol 128 (05) ◽

pp. 319-324 ◽

Cited By ~ 2

Author(s):

Laila Ben Lamine ◽

Amira Turki ◽

Ghada Al-Khateeb ◽

Nejla Sellami ◽

Hagger B. Amor ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Linear Regression Analysis ◽

Plasma Concentrations ◽

Cd40 Ligand ◽

Significant Finding ◽

Characteristic Analysis ◽

Soluble Cd40 Ligand ◽

Type 2 Diabetic ◽

Type 2 Diabetic Retinopathy

Abstract Background To investigate the relationship between changes in circulating soluble CD40 ligand (sCD40L) levels and the presence and severity of type 2 diabetic retinopathy (DR). Subjects and methods sCD40L plasma concentrations were measured in 205 type 2 diabetes (T2DM) patients without DR (DWR; n=50) and with DR (n=155), the latter subdivided into non-proliferative diabetic retinopathy [NPDR; n=98 (63.2%)], or proliferative retinopathy [PDR; n=57 (36.8%)] patients. Results Receiver operating characteristic analysis provided good discriminatory power for sCD40L as predictor of DR presence, with high sensitivity and specificity. Categorizing DWR and DR patients into sCD40L quartiles, based on sCD40L concentrations in T2DM without DR, demonstrated statistically significant gradual increase in DR risk with increasing sCD40L levels. sCD40L levels were significantly higher in DR compared to DWR patients. Plasma sCD40L levels differed significantly according to DR severity, and correlated with diabetes duration, dyslipedimea, nephropathy, and presence of DR, but not with gender, age, SBP, DBP, FPG, HbA1c, T2DM medications. Linear regression analysis confirmed the association of increased sCD40L levels with DR, independent of others parameters; mean plasma sCD40L levels differing significantly according to DR severity. Conclusion Plasma sCD40L levels were positively associated with DR. The significant finding here is that sCD40L levels can be predictors of DR severity.

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A cross-sectional assessment of health-related quality of life among type 2 diabetic patients in Pakistan

Journal of Pharmacy And Bioallied Sciences ◽

10.4103/0975-7406.171734 ◽

2016 ◽

Vol 8 (1) ◽

pp. 64 ◽

Cited By ~ 3

Author(s):

Fahad Saleem ◽

Saeedur Rashid Nazir ◽

MohamedAzmi Hassali ◽

Sajid Bashir ◽

Furqan Hashmi ◽

...

Keyword(s):

Quality Of Life ◽

Diabetic Patients ◽

Health Related Quality ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Related Quality ◽

Health Related ◽

Type 2 Diabetic

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Visual Outcomes, Quality of Life and Satisfaction After Phacoemulsification in Patients With Type 2 Diabetes Mellitus and Patients Without Diabetes

10.21203/rs.3.rs-108487/v1 ◽

2020 ◽

Author(s):

Joao Beato ◽

Sonia Torres-Costa ◽

Joao Esteves-Leandro ◽

Manuel Falcão ◽

Vitor Rosas ◽

...

Keyword(s):

Quality Of Life ◽

Visual Acuity ◽

Patient Reported Outcomes ◽

Diabetic Patients ◽

Patient Reported ◽

Visual Function Questionnaire ◽

The Mean ◽

Type 2 Diabetic

Abstract BackgroundDiabetic retinopathy (DR) and cataract are major complications that lead to significant visual impairment of diabetic patients. This study aims to compare the changes in visual acuity, quality of life and satisfaction after phacoemulsification between type 2 diabetic and nondiabetic patients.MethodsFifty-seven diabetic patients (37 with no diabetic retinopathy [DR], 11 with mild/moderate nonproliferative DR and 9 with severe nonproliferative/proliferative DR) and 45 controls were submitted to first-eye cataract surgery by phacoemulsification alone or with co-adjuvant intravitreal injection of bevacizumab or triamcinolone. National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was recorded preoperatively and 6 months after surgery; and satisfaction evaluated at 1-month. ResultsCorrected distance visual acuity (CDVA) of the operated eye at 1 and 6-months (p<0.001) was significantly higher than preoperative value in the controls and all diabetic subgroups. The final CDVA in the severe nonproliferative/proliferative DR subgroup was significantly lower compared to the controls and the remaining diabetic subgroups (p<0.05). The mean NEI VFQ-25 composite score significantly improved in both control (15.413.2 points) and diabetic (15.413.0 points) groups, without differences among the diabetic subgroups (p>0.05). Overall patient satisfaction was 93% in both control and diabetic groups. ConclusionThis study provides vision-related patient-reported outcomes that support the benefit from phacoemulsification in all stages of DR, as long as there is adequate monitoring and treatment of retinopathy.

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