A Case of Maternal Vitamin K Deficiency Associated with Hyperemesis Gravidarum: Its Potential Impact on Fetal Blood Coagulability

Hyperemesis gravidarum can cause various vitamin deficiencies. Vitamin K deficiency can lead to coagulopathy or hemorrhagic diathesis. A nulliparous Japanese woman with hyperemesis gravidarum at 105/7weeks was admitted with giant myoma, intestinal obstruction, and abdominal pain. Treatment for a degenerative myoma was instituted with intravenous antibiotics. The abdominal pain ameliorated, but intestinal obstruction persisted. At 166/7weeks, we performed laparotomy for release of intestinal obstruction, when intraabdominal bleeding of 110 mL existed. Blood tests revealed coagulopathy secondary to vitamin K deficiency. The coagulopathy responded to intravenous vitamin K injection. Coagulopathy due to vitamin K deficiency can occur with hyperemesis gravidarum, and coexisting intestinal obstruction and broad-spectrum antibiotics can aggravate the deficiency.

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Gray matter heterotopias and brachytelephalangic chondrodysplasia punctata: A complication of hyperemesis gravidarum induced vitamin K deficiency?

American Journal of Medical Genetics Part A ◽

10.1002/ajmg.a.31573 ◽

2007 ◽

Vol 143A (2) ◽

pp. 200-204 ◽

Cited By ~ 19

Author(s):

Nicola Brunetti-Pierri ◽

Jill V. Hunter ◽

Cornelius F. Boerkoel

Keyword(s):

Vitamin K ◽

Gray Matter ◽

Hyperemesis Gravidarum ◽

Chondrodysplasia Punctata ◽

Vitamin K Deficiency ◽

K Deficiency

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Coagulopathy secondary to vitamin K deficiency in hyperemesis gravidarum

Obstetrics and Gynecology ◽

10.1016/s0029-7844(98)00150-1 ◽

1998 ◽

Vol 92 (4) ◽

pp. 673-675 ◽

Cited By ~ 17

Author(s):

J ROBINSON

Keyword(s):

Vitamin K ◽

Hyperemesis Gravidarum ◽

Vitamin K Deficiency ◽

K Deficiency

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Binder phenotype and brachytelephalangic chondrodysplasia punctata secondary to maternal vitamin K deficiency

Clinical Dysmorphology ◽

10.1097/mcd.0b013e328335c14a ◽

2010 ◽

Vol 19 (2) ◽

pp. 85-87 ◽

Cited By ~ 10

Author(s):

Jean-Luc Dominique Alessandri ◽

Duksha Ramful ◽

Fabrice Cuillier

Keyword(s):

Vitamin K ◽

Chondrodysplasia Punctata ◽

Vitamin K Deficiency ◽

Maternal Vitamin ◽

K Deficiency

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Vitamin K Deficiency Embryopathy from Hyperemesis Gravidarum

Case Reports in Obstetrics and Gynecology ◽

10.1155/2015/324173 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3 ◽

Cited By ~ 2

Author(s):

Andrew S. Lane ◽

Jennifer L. Stallworth ◽

Kacey Y. Eichelberger ◽

Kenneth F. Trofatter

Keyword(s):

Vitamin K ◽

Enteral Feeding ◽

Hyperemesis Gravidarum ◽

Severe Form ◽

Common Condition ◽

Vitamin K Deficiency ◽

Facial Profile ◽

Prepregnancy Weight ◽

K Deficiency ◽

Nasal Hypoplasia

A 21-year-old primigravida had a pregnancy complicated by hyperemesis gravidarum (HG) beginning at 7-week gestation. Despite medical therapy, she lost 18% of her prepregnancy weight. Early ultrasound at 14 weeks demonstrated a flattened facial profile with nasal hypoplasia (Binder phenotype) consistent with vitamin K deficiency from HG. She had a percutaneous endoscopic gastrojejunostomy tube placed for enteral feeding at 15-week gestation. At repeated anatomy ultrasound at 21-week gestation, delivery, and postnatal pediatric genetics exam, nasal hypoplasia was consistent with vitamin K deficiency embryopathy from HG. Nausea and vomiting of pregnancy is a common condition. HG, the most severe form, has many maternal and fetal effects. Evaluation of vitamin K status could potentially prevent this rare and disfiguring embryopathy.

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