scholarly journals 3. Gene Delivery and Expression Series Overexpression of Recombinant Protein in Large-scale Culture Using a Baculovirus-insect Cell Expression System: Based on the Study of Xanthine Oxidoreductase (3)

2012 ◽  
Vol 8 (1) ◽  
pp. 26-30
Author(s):  
Yuko Kawaguchi ◽  
Ken Okamoto
Keyword(s):  
Recombinant Protein ◽  
Insect Cell ◽  
Large Scale ◽  
Expression System ◽  
Xanthine Oxidoreductase ◽  
Insect Cell Expression System ◽  
Large Scale Culture ◽  
Cell Expression ◽  
Insect Cell Expression ◽  
Cell Expression System

Ecdysteroids increase the yield of recombinant protein produced in baculovirus insect cell expression system

1990 ◽  
Vol 167 (3) ◽  
pp. 1154-1161 ◽  
Author(s):  
Miklós Sárvári ◽  
György Csikós ◽  
Miklós Sass ◽  
Péter Gál ◽  
Verne N. Schumaker ◽  
...  
Keyword(s):  
Recombinant Protein ◽  
Insect Cell ◽  
Expression System ◽  
Insect Cell Expression System ◽  
Cell Expression ◽  
Insect Cell Expression ◽  
Cell Expression System

scholarly journals Innovations in the Insect Cell Expression System for Industrial Recombinant Vaccine Antigen Production

Vaccines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1504
Author(s):  
Manon M. J. Cox
Keyword(s):  
Insect Cell ◽  
Large Scale ◽  
Influenza Pandemic ◽  
Expression System ◽  
Vaccine Antigen ◽  
Scale Production ◽  
Insect Cell Expression System ◽  
Cell Expression ◽  
Insect Cell Expression ◽  
Cell Expression System

The insect cell expression system has previously been proposed as the preferred biosecurity strategy for production of any vaccine, particularly for future influenza pandemic vaccines. The development and regulatory risk for new vaccine candidates is shortened as the platform is already in use for the manufacturing of the FDA-licensed seasonal recombinant influenza vaccine Flublok®. Large-scale production capacity is in place and could be used to produce other antigens as well. However, as demonstrated by the 2019 SARS-CoV-2 pandemic the insect cell expression system has limitations that need to be addressed to ensure that recombinant antigens will indeed play a role in combating future pandemics. The greatest challenge may be the ability to produce an adequate quantity of purified antigen in an accelerated manner. This review summarizes recent innovations in technology areas important for enhancing recombinant-protein production levels and shortening development timelines. Opportunities for increasing product concentrations through vector development, cell line engineering, or bioprocessing and for shortening timelines through standardization of manufacturing processes will be presented.

Protein production using the baculovirus-insect cell expression system

2013 ◽  
Vol 30 (1) ◽  
pp. 1-18 ◽  
Author(s):  
A. Contreras-Gómez ◽  
A. Sánchez-Mirón ◽  
F. García-Camacho ◽  
E. Molina-Grima ◽  
Y. Chisti
Keyword(s):  
Insect Cell ◽  
Protein Production ◽  
Expression System ◽  
Insect Cell Expression System ◽  
Cell Expression ◽  
Insect Cell Expression ◽  
Cell Expression System
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