Treatment of bronchopulmonary dysplasia in children at the modern stage: the main problems and achievements

2014 ◽  
Vol 20 (29) ◽  
pp. 48-54
Author(s):  
Касохова ◽  
V. Kasokhova ◽  
Фидарова ◽  
A. Fidarova ◽  
Касохов ◽  
...  
Keyword(s):  
Bronchopulmonary Dysplasia ◽  
Infectious Complications ◽  
Respiratory Support ◽  
Prevention And Treatment

The informations about current opportunities therapy of bronchopulmonary dysplasia in children is presented in this review. Their assessment on the basis of the results of various studies carried out on the principles of evidence medicine was performed. The main achievements and problems in the treatment of bronchopulmonary dysplasia were revealed. The information about the principles of effective respiratory support, the principles of systemic and inhaled corticosteroids use, about the prospects for the late appointment of surfactant in children with bronchopulmonary dysplasia, etc. was presented. The questions of prevention and treatment of infectious complications of bronchopulmonary dysplasia were highlighted. The prospects of the therapy of this disease in children were determined.

scholarly journals Room air challenge predicts duration of supplemental respiratory support for infants with bronchopulmonary dysplasia

2021 ◽  
Author(s):  
Puneet Arora ◽  
Allison Dahlgren ◽  
Sara Dawson ◽  
Jonathan Leuthner ◽  
Joanne Lagatta
Keyword(s):  
Bronchopulmonary Dysplasia ◽  
Respiratory Support

Lung Ultrasound in Bronchopulmonary Dysplasia: Patterns and Predictors in Very Preterm Infants

Neonatology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Victoria Aldecoa-Bilbao ◽  
Mar Velilla ◽  
Marta Teresa-Palacio ◽  
Carla Balcells Esponera ◽  
Ana Herranz Barbero ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Lung Ultrasound ◽  
Respiratory Support ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Pleural Line ◽  
Respiratory Management ◽  
Postmenstrual Age ◽  
Severity Of The Disease

<b><i>Introduction:</i></b> Lung ultrasound (LUS) is useful for respiratory management in very preterm infants (VPI), but little is known about the echographic patterns in bronchopulmonary dysplasia (BPD), the relation between the image findings, and the severity of the disease and its long-term outcomes. We aimed to describe LUS patterns in BPD and analyze the accuracy of LUS to predict the need for respiratory support at 36 weeks postmenstrual age (PMA) in VPI. <b><i>Methods:</i></b> Preterm infants ≤30.6 weeks of gestational age were recruited. LUS was performed at admission, at 7th, and 28th day of life (DOL) with a standardized protocol (6 zones: anterior, lateral, and posterior fields). Clinical data, respiratory outcomes, and image findings were recorded. <b><i>Results:</i></b> Eighty-nine patients were studied. Infants with BPD had significantly higher LUS score at admission, at 7th, and 28th DOL. Patients with BPD exhibited more consolidations and pleural line abnormalities at 7th and 28th DOL than those without BPD (<i>p</i> &#x3c; 0.001), regardless of the definition used for BPD. LUS at 7th DOL predicted <i>NICHD 2001-BPD</i> with <i>R</i><sup>2</sup> = 0.522; AUC = 0.87 (0.79–0.94), <i>p</i> &#x3c; 0.001, and <i>Jensen 2019-BPD</i> with <i>R</i><sup>2</sup> = 0.315 (AUC = 0.80 [0.70–0.90], <i>p</i> &#x3c; 0.001). A model including mechanical ventilation &#x3e;5 days, oxygen therapy for 7 days and LUS score at 7th DOL accurately predicted the need for respiratory support at 36 weeks PMA (<i>R</i><sup>2</sup> = 0.655, <i>p</i> &#x3c; 0.001) with an AUC = 0.90 (0.84–0.97), <i>p</i> &#x3c; 0.001. <b><i>Conclusion:</i></b> LUS score, pleural line abnormalities, and consolidations can be useful to diagnose BPD in VPI and to predict its severity after the first week of life.

scholarly journals Searching for better animal models of BPD: a perspective

2016 ◽  
Vol 311 (5) ◽  
pp. L924-L927 ◽  
Author(s):  
Namasivayam Ambalavanan ◽  
Rory E. Morty
Keyword(s):  
Animal Models ◽  
Bronchopulmonary Dysplasia ◽  
Prevention And Treatment

There have been many efforts to develop good animal models of bronchopulmonary dysplasia (BPD) to better understand the pathophysiology and mechanisms underlying development of BPD as well as to test potential strategies for its prevention and treatment. This Perspectives summarizes the features of common animal models of BPD and the strengths and limitations of such models. Potential optimal approaches to development of animal models are indicated, with the underlying concepts that require emphasis.

scholarly journals Respiratory Tract Microecology and Bronchopulmonary Dysplasia in Preterm Infants

2021 ◽  
Vol 9 ◽  
Author(s):  
Tong Sun ◽  
Haiyang Yu ◽  
Jianhua Fu
Keyword(s):  
Respiratory Tract ◽  
Microbial Diversity ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Premature Infants ◽  
Respiratory Complication ◽  
Prevention And Treatment ◽  
New Ideas

Bronchopulmonary dysplasia (BPD) is a severe respiratory complication in preterm infants. Although the etiology and pathogenesis of BPD are complex and remain to be clarified, recent studies have reported a certain correlation between the microecological environment of the respiratory tract and BPD. Changes in respiratory tract microecology, such as abnormal microbial diversity and altered evolutional patterns, are observed prior to the development of BPD in premature infants. Therefore, research on the colonization and evolution of neonatal respiratory tract microecology and its relationship with BPD is expected to provide new ideas for its prevention and treatment. In this paper, we review microecological changes in the respiratory tract and the mechanisms by which they can lead to BPD in preterm infants.

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