Lipid peroxidation and antioxidant system in patients with acute мyocardial infarction and diabetes mellitus type 2
Problems of the treatment of comorbid patients in routine clinical practice remain highly relevant. One of the most common combinations – coronary heart disease and diabetes mellitus type 2. In this article, the authors present their own experience of studying the effects of infusion of the drug "Reamberin" at the stage of percutaneous coronary intervention on the dynamics of indicators of lipid peroxidation in patients with myocardial infarction with diabetes mellitus type 2. This study consists of the examination and treatment analysis of 54 patients, men aged 64,3 ± 6,8 years old with coronary heart disease and clinical manifestations of acute myocardial infarction and concomitant diabetes mellitus type 2. The percutaneous intervention was made of this group of patients. To determine the normal values of the studied parameters, the examination of 34 patients with coronary heart disease without exacerbation (men aged 62,5 ± 4,2 years) with concomitant diabetes mellitus type 2, was carried out. It is found that the development of acute myocardial infarction in patients with diabetes type 2 is accompanied by activation of processes of lipid peroxidation and antioxidant system of blood with a predominance of lipid peroxidation. It is proved that the use of succinic acid drug "Reamberin" at the stage of percutaneous coronary intervention in these patients contributes to the decrease in the intensity of free radical processes and increases the activity of enzymatic antioxidants.