Cold-hot Nature Distinguish of Traditional Chinese Medicinal Herbs by Discriminant Analysis of 1H-NMR Spectral Data

In the work we presented the behavior of 5-(4-(4-X-phenylsulfonyl)phenyl)-4-(n-propyl)-2H-1,2,4-triazole-3(4H)-thiones (X= Cl or Br) with some alkylation agents. Thus, new S-alkylated 1,2,4-triazole derivatives were synthesized by reaction of the corresponding 1,2,4-triazole-3-thione derivatives with different �-halogenated compounds (ethyl bromide, ethyl chloroacetate or phenacyl bromide), in basic medium. The structures of synthesized compounds were elucidated by spectral data (1H-NMR, 13C-NMR, mass spectrometry) and elemental analysis.

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Green Synthetic Protocol for (E)-1-Aryl-3-(2-morpholinoquinolin- 3-yl)prop-2-en-1-ones and Their Antimicrobial Activity

Asian Journal of Chemistry ◽

10.14233/ajchem.2019.21968 ◽

2019 ◽

Vol 31 (9) ◽

pp. 1895-1898

Author(s):

Relangi Siva Subrahmanyam ◽

Venkateswara Rao Anna

Keyword(s):

Antimicrobial Activity ◽

Spectral Data ◽

1H Nmr ◽

13C Nmr ◽

Mass Spectral Data ◽

In Vitro Antimicrobial Activity ◽

Mass Spectral ◽

Fungal Organisms

We report here an easy, efficient and green synthetic protocol for the (E)-1-aryl-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones by the Claisen-Schmidt condensation of 2-morpholinoquinoline-3-carbaldehyde and different substituted acetophenones by using 1-butyl-3-methylimidazolium tetrafluoroborate (Bmim)BF4. The compounds were characterized by using 1H NMR, 13C NMR and mass spectral data and screened there in vitro antimicrobial activity against different bacterial and fungal organisms.

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Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of aflatoxin B1

Mutation Research/Genetic Toxicology ◽

10.1016/0165-1218(92)90069-c ◽

1992 ◽

Vol 279 (3) ◽

pp. 209-216 ◽

Cited By ~ 20

Author(s):

Brian Y.Y. Wong ◽

Benjamin H.S. Lau ◽

Padma P. Tadi ◽

Robert W. Teel

Keyword(s):

Dna Binding ◽

Aflatoxin B1 ◽

Medicinal Herbs ◽

Chinese Medicinal Herbs

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Comparative in vitro antimicrobial activity of chinese medicinal herbs

Journal of Ethnopharmacology ◽

10.1016/0378-8741(86)90166-2 ◽

1986 ◽

Vol 15 (3) ◽

pp. 279-288 ◽

Cited By ~ 23

Author(s):

Scott G. Franzblau ◽

Christina Cross

Keyword(s):

Antimicrobial Activity ◽

Medicinal Herbs ◽

Chinese Medicinal Herbs ◽

In Vitro Antimicrobial Activity

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Treatment of precocious puberty in a McCune–Albright syndrome patient using Chinese medicinal herbs combined with megestrol acetate: A case report

Traditional Medicine and Modern Medicine ◽

10.1142/s2575900018720011 ◽

2018 ◽

Vol 01 (01) ◽

pp. 69-74

Author(s):

Wen Sun ◽

Yonghong Wang ◽

Jian Yu ◽

Min Ji

Keyword(s):

Precocious Puberty ◽

Bone Dysplasia ◽

Medicinal Herbs ◽

Megestrol Acetate ◽

Chinese Medicinal Herbs ◽

Gene Encoding ◽

Mccune Albright Syndrome ◽

Activating Mutation ◽

Albright Syndrome ◽

Mccune Albright

Introduction: McCune–Albright Syndrome (MAS) is a rare congenital sporadic disorder characterized by fibrous bone dysplasia, café-au-lait pigmented spots on the skin, and non-gonadotropin dependent precocious puberty (PP), which is caused by a postzygotic somatic activating mutation in the GNAS gene encoding the alpha subunit of Gs protein. In our case study, we recorded a girl with the onset of MAS and treated her with Chinese medicinal herbs combined with megestrol acetate. We aim to provide a method for the treatment of children with this rare form of precocious puberty. Case Presention: A 4-year-old girl presented with vaginal bleeding and enlarged breasts. The activating mutation of GNAS was not detected in the patient’s peripheral blood samples, as some had reported. Because of peripheral PP and fibrous dysplasia of the diagnosed bone, the patient was considered as MAS. We chose the Chinese medicinal herbs combined with megestrol acetate for treatment, and the patient was effectively treated. Conclusion: The combination therapy of Chinese medicinal herbs plus megestrol acetate in managing PP in an MAS is one of the useful treatments.

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