Inhibitory Effect of Camel Urine on Neoplastic and Transformed Cell Lines

2013 ◽  
Vol 8 (2) ◽  
pp. 31-35 ◽  
Author(s):  
Mohammed M. F. Al-Halbosiy ◽  
Rakad M. Kh. Al-Jumaily ◽  
Fadhel M. Lafta ◽  
Hussam M. Hassan
Keyword(s):  
Cell Lines ◽  
Inhibitory Effect ◽  
Transformed Cell ◽  
Transformed Cell Lines

scholarly journals Iodide symporter gene expression in normal and transformed rat thyroid cells

1999 ◽  
pp. 447-451 ◽  
Author(s):  
F Trapasso ◽  
R Iuliano ◽  
E Chiefari ◽  
F Arturi ◽  
A Stella ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Inhibitory Effect ◽  
Mrna Levels ◽  
Iodide Uptake ◽  
Thyroid Cells ◽  
Transformed Cell ◽  
Nis Gene ◽  
Rat Thyroid ◽  
Transformed Cell Lines

OBJECTIVE: Decrease or loss of the Na+/I- symporter (NIS) activity profoundly affects the suitability of the use of radioiodine to detect or treat metastatic thyroid tissues. The aim of our study was to verify whether specific oncogene abnormalities were responsible for the alteration in NIS activity in thyroid cells. DESIGN AND METHODS: Expression of the NIS gene was investigated by Northern blot analysis in normal and in some oncogene-transformed cell lines with different degrees of malignancy which had lost the iodide uptake ability. RESULTS: NIS gene expression was up-regulated by TSH in a dose-dependent and time-dependent way in normal PC Cl 3 cells. The same effect was observed by activating the cAMP-dependent pathway by forskolin. Conversely, insulin and 12-O-tetradecanoylphorbol-13-acetate (TPA) showed a partial inhibitory effect on NIS gene expression. The oncogene-transformed cell lines PC v-erbA, PC HaMSV, PC v-raf, and PC E1A cells showed reduced NIS mRNA levels compared with the normal PC Cl 3 cells. Conversely, an almost complete absence of NIS gene expression was found in PC RET/PTC, PC KiMSV, PC p53(143ala), and PC PyMLV cell lines. CONCLUSIONS: Our data show that oncogene activation could play a role in affecting the iodide uptake ability in thyroid tumoral cells; different mechanisms are involved in the oncogene-dependent loss of NIS activity in transformed thyroid cells.

scholarly journals Effect of tunicamycin on cell growth and morphology of nontransformed and transformed cell lines.

1979 ◽  
Vol 43 (7) ◽  
pp. 1553-1561 ◽  
Author(s):  
Kenji KOHNO ◽  
Akiyoshi HIRAGUN ◽  
Hiromi MITSUI ◽  
Akira TAKATSUKI ◽  
Gakuzo TAMURA
Keyword(s):  
Cell Growth ◽  
Cell Lines ◽  
Transformed Cell ◽  
Transformed Cell Lines

scholarly journals G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA

2015 ◽  
Vol 209 (1) ◽  
pp. 73-84 ◽  
Author(s):  
Anaïs Aulas ◽  
Guillaume Caron ◽  
Christos G. Gkogkas ◽  
Nguyen-Vi Mohamed ◽  
Laurie Destroismaisons ◽  
...  
Keyword(s):  
Normal Stress ◽  
Cell Lines ◽  
Translational Repression ◽  
Primary Neurons ◽  
Processing Bodies ◽  
Transformed Cell ◽  
Upstream Regulator ◽  
Functional Consequences ◽  
Transformed Cell Lines ◽  
Polyadenylated Mrna

G3BP1, a target of TDP-43, is required for normal stress granule (SG) assembly, but the functional consequences of failed SG assembly remain unknown. Here, using both transformed cell lines and primary neurons, we investigated the functional impact of this disruption in SG dynamics. While stress-induced translational repression and recruitment of key SG proteins was undisturbed, depletion of G3BP1 or its upstream regulator TDP-43 disturbed normal interactions between SGs and processing bodies (PBs). This was concomitant with decreased SG size, reduced SG–PB docking, and impaired preservation of polyadenylated mRNA. Reintroduction of G3BP1 alone was sufficient to rescue all of these phenotypes, indicating that G3BP1 is essential for normal SG–PB interactions and SG function.

The preferential cytotoxicity of reovirus for certain transformed cell lines

1977 ◽  
Vol 54 (4) ◽  
pp. 307-315 ◽  
Author(s):  
G. Hashiro ◽  
P. C. Loh ◽  
Jenny T. Yau
Keyword(s):  
Cell Lines ◽  
Transformed Cell ◽  
Transformed Cell Lines

scholarly journals Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation.

1991 ◽  
Vol 88 (9) ◽  
pp. 3792-3796 ◽  
Author(s):  
R. A. Cruciani ◽  
J. L. Barker ◽  
M. Zasloff ◽  
H. C. Chen ◽  
O. Colamonici
Keyword(s):  
Cell Lines ◽  
Cytolytic Activity ◽  
Channel Formation ◽  
Transformed Cell ◽  
Transformed Cell Lines
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