Risk of cancer in an occupationally exposed cohort with increased level of chromosomal aberrations.

1 Twenty-five male workers occupationally exposed to DDT, BHC malathion, parathion, dimethoate, fenitrothion, urea and gromor were selected as subjects for the analysis of chromosomal aberrations and sister chromatid exchanges (SCE) in peripheral lymphocytes. 2 Blood samples were collected from 30 normal healthy males from the same age group and socioeconomic class for the control. 3 The frequency of chromosomal aberrations and SCEs increased significantly irrespective of the duration of exposure to pesticides, when compared to controls.

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The effects of exposure to different clastogens on the pattern of chromosomal aberrations detected by FISH whole chromosome painting in occupationally exposed individuals

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/j.mrfmmm.2005.07.009 ◽

2006 ◽

Vol 594 (1-2) ◽

pp. 20-29 ◽

Cited By ~ 13

Author(s):

O. Beskid ◽

Z. Dušek ◽

I. Solanský ◽

R.J. Šrám

Keyword(s):

Chromosomal Aberrations ◽

Chromosome Painting ◽

Occupationally Exposed ◽

Whole Chromosome Painting

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Occupational low-dose irradiation and cancer risk among medical radiation workers

Occupational Medicine ◽

10.1093/occmed/kqaa130 ◽

2020 ◽

Vol 70 (7) ◽

pp. 476-484 ◽

Cited By ~ 1

Author(s):

H Chartier ◽

P Fassier ◽

K Leuraud ◽

S Jacob ◽

C Baudin ◽

...

Keyword(s):

Epidemiological Studies ◽

Cancer Risks ◽

Quality Of Information ◽

Strength Of Evidence ◽

Cancer Occurrence ◽

Occupationally Exposed ◽

Radiation Workers ◽

Risk Of Cancer ◽

Dosimetry Data

Abstract Background Medical workers are the largest group of workers occupationally exposed to low doses of ionizing radiation (IR) worldwide. Aims This review presents all the cohorts of medical workers exposed in the world and summarizes cancer risks associated with radiation exposure in this population. Methods Epidemiological studies on health professionals exposed to IR published from 1975 to 2019 were reviewed. Strength of evidence was assessed according to the modified Royal College of General Practitioners three-star system. Results Among the 16 epidemiological studies focusing on cancers from 11 cohorts among medical staff exposed to radiation, higher risks of cancer were observed for pre-1950 exposure and for medical workers who performed fluoroscopically guided interventional procedures or radionuclides procedures compared to those who did not. However, strength of evidence supporting the associations remains moderate as several methodological limits including the lack of dosimetry data, lifestyle factors and recent updates may obscure the link between medical occupational exposure and cancer occurrence. Conclusions Excess risk of cancer is suspected for high and former exposures. The more highly exposed professions, i.e. interventional physicians and nuclear medicine workers, should be monitored carefully. Collaborative projects aiming to increase the quantity and quality of information of the studied populations would be a key point

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