Systems Toxicology and the Chemical Effects in Biological Systems (CEBS) Knowledge Base

Almost from the outset, most large companies saw the ‘new biotechnology’ not as a new business but as a set of very powerful techniques that, in time, would radically improve the understanding of biological systems. This new knowledge was generally seen by them as enhancing the process of invention and not as a substitute for tried and tested ways of meeting clearly identified targets. As the knowledge base grows, so the big-company response to biotechnology becomes more positive. Within ICI, biotechnology is now integrated into five biobusinesses (Pharmaceuticals, Agrochemicals, Seeds, Diagnostics and Biological Products). Within the Central Toxicology Laboratory it also contributes to the understanding of the mechanisms of toxic action of chemicals as part of assessing risk. ICI has entered two of these businesses (Seeds and Diagnostics) because it sees biotechnology making a major contribution to the profitability of each.

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Towards standards for data exchange and integration and their impact on a public database such as CEBS (Chemical Effects in Biological Systems)

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2008.06.015 ◽

2008 ◽

Vol 233 (1) ◽

pp. 54-62 ◽

Cited By ~ 14

Author(s):

Jennifer M. Fostel

Keyword(s):

Data Exchange ◽

Biological Systems ◽

Public Database ◽

Chemical Effects

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A knowledge base for integrated biological systems

IEEE Intelligent Systems ◽

10.1109/5254.972085 ◽

2001 ◽

Vol 16 (6) ◽

pp. 52-61 ◽

Cited By ~ 2

Author(s):

C. Capponi ◽

J. Chabalier ◽

Y. Quentin ◽

G. Fichant

Keyword(s):

Knowledge Base ◽

Biological Systems

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Characterization of Antimonium crudum Activity Using Solvatochromic Dyes

Homeopathy ◽

10.1055/s-0039-1697000 ◽

2019 ◽

Vol 109 (02) ◽

pp. 079-086 ◽

Cited By ~ 1

Author(s):

Leoni Villano Bonamin ◽

Renata Rossettini Palombro Pedro ◽

Hannah Maureen G. Mota ◽

Michelle S. Correia Aguiar ◽

Sandra A. G. Pinto ◽

...

Keyword(s):

Dipole Moments ◽

Biological Effects ◽

Biological Systems ◽

Chemical Effects ◽

Solvatochromic Dyes ◽

Physico Chemical ◽

Visible Spectra ◽

Methylene Violet

Abstract Background The mechanism by which highly diluted and agitated solutions have their effect is still unknown, but the development in recent years of new methods identifying changes in water and solute dipole moments is providing insights into potential modes of action. Objective The objective of the current study was to compare the biological effects of Antimonium crudum (AC) previously obtained by our group and already described in the literature with now measurable physico-chemical effects on solvatochromic dyes. Methods Different dilutions of AC and succussed water have been characterized with respect to their effect on the visible spectra of the solvatochromic dyes methylene violet (MV), a pyridinium phenolate (ET33), and a dimethylamino naphthalenone (BDN) compared with in-vitro action against Leishmania amazonensis-infected macrophages. Results Dye responses varied according to the dye used and the level of AC dilution and results were found to corroborate previously published in-vivo and in-vitro effects of AC. In addition, a very significant enhancement in the absorbance increase of MV was seen using the supernatant from AC 200cH-treated cells (15%; p < 0.0001) over that seen with AC 200cH itself (4%; p = 0.034), suggesting the amplification of ultra-high dilution effects by biological systems. Furthermore, supernatants from AC-treated cells increased the range of dilutions of AC that were capable of producing effects on the spectra of MV. The effect of AC dilutions on dye ET33 was eliminated by a weak electric current passed through potency solutions. Conclusion The data confirm a correspondence between the biological effects of dilutions of AC in-vitro and physico-chemical effects on solvatochromic dyes as measured by changes in their visible spectra. Results also indicate high dilutions of AC are sensitive to exposure to electric currents and biological systems.

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Chemical Effects in Biological Systems—Data Dictionary (CEBS-DD): A Compendium of Terms for the Capture and Integration of Biological Study Design Description, Conventional Phenotypes, and ‘Omics Data

Toxicological Sciences ◽

10.1093/toxsci/kfi315 ◽

2005 ◽

Vol 88 (2) ◽

pp. 585-601 ◽

Cited By ~ 28

Author(s):

Jennifer Fostel ◽

Danielle Choi ◽

Craig Zwickl ◽

Norman Morrison ◽

Asif Rashid ◽

...

Keyword(s):

Study Design ◽

Biological Systems ◽

Biological Study ◽

Data Dictionary ◽

Omics Data ◽

Chemical Effects

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Enzymes: Nature's Nanomachines

Biochemical Society Transactions ◽

10.1042/bst0290331 ◽

2001 ◽

Vol 29 (2) ◽

pp. 331-336 ◽

Cited By ~ 1

Author(s):

T.J. Mantle

Keyword(s):

Enzyme Kinetics ◽

Knowledge Base ◽

Biological Systems ◽

Protein Crystallography ◽

Industrial Applications ◽

First Century ◽

Nmr Studies ◽

Novel Technologies ◽

Useful Knowledge ◽

Mechanistic Biology

The development of enzyme kinetics, protein crystallography and NMR studies allows enzymecatalysed reactions to be described in terms of mechanistic chemistry, albeit applied to relatively enormous molecules. These nanomachines, which so inspired Drexler's Engines of Creation, have been working in biological systems for over three billion years and represent a useful knowledge base for our further understanding of mechanistic biology. They also provide a tantalizing glimpse into what may be the basis for novel technologies with industrial applications for the twenty-first century.

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