scholarly journals When the Treatment is the Cause: Disseminated Bacille Calmette–Guérin Infection

Author(s):  
Ana Teresa Marques Afonso ◽  
Montserrat Rodríguez Framil ◽  
Joaquín Sánchez Leira ◽  
Néstor Vázquez Agra ◽  
Federico García-Rodeja Arias

Bacille Calmette–Guérin (BCG) administration for superficial bladder cancer is a well-tolerated and very effective therapy. However, unpredictable systemic complications may occur on rare occasions. We present the case of a patient who attended for consultation because of fever, asthenia and weight loss following BCG immunotherapy. The clinical response to treatment and computed tomography scanning were key to diagnosis.

2012 ◽  
Vol 1 (3) ◽  
Author(s):  
Vincent Fradet ◽  
Christiane Gaudreau ◽  
Paul Perrotte ◽  
Jean Côté ◽  
Jean-Marie Paquin

Intravesical bacille Calmette-Guérin (BCG) therapy is the most effective treatmentfor high-risk superficial bladder cancer. Severe systemic complications are rare, but may occur in approximately 1% of cases. We report a severe complicationof intravesical BCG: a disseminated Mycobacterium bovis infectionwith biopsy-proven granulomatous hepatitis in a patient with bladder cancer. We also elaborate on the different management alternatives.


2021 ◽  
Vol 9 ◽  
pp. 232470962199724
Author(s):  
Bradley C. Sanville ◽  
Brooks T. Kuhn

A 56-year-old man presented with subacute night sweats, fever, and weight loss with worsening dyspnea. Computed tomography (CT) scan demonstrated miliary pattern of nodules evenly distributed throughout all lung fields. Given the patient’s CT findings and temporal association with Bacille Calmette-Guerin (BCG) immunotherapy for bladder cancer, the patient was diagnosed with disseminated Mycobacterium bovis secondary to BCG bladder instillations.


2017 ◽  
Vol 83 (3) ◽  
pp. 557-561 ◽  
Author(s):  
Marta J. Madurska ◽  
Jan O. Jansen ◽  
Viktor A. Reva ◽  
Mohammed Mirghani ◽  
Jonathan J. Morrison

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