scholarly journals Swine Interleukin 2 Activity Produced by Mesenteric Lymph Node Cells.

1993 ◽  
Vol 55 (5) ◽  
pp. 729-734 ◽  
Author(s):  
Hiroyuki IWATA ◽  
Tatsuo UEDA ◽  
Kyoko TAKAYANAGI ◽  
Mutsumi WADA ◽  
Takeshi INOUE
Keyword(s):  
Lymph Node ◽  
Mesenteric Lymph Node ◽  
Interleukin 2 ◽  
Mesenteric Lymph ◽  
Lymph Node Cells

scholarly journals Intranasal Immunization with SAG1 and Nontoxic Mutant Heat-Labile Enterotoxins Protects Mice againstToxoplasma gondii

2001 ◽  
Vol 69 (3) ◽  
pp. 1605-1612 ◽  
Author(s):  
C. Bonenfant ◽  
I. Dimier-Poisson ◽  
F. Velge-Roussel ◽  
D. Buzoni-Gatel ◽  
G. Del Giudice ◽  
...  
Keyword(s):  
Lymph Node ◽  
Mesenteric Lymph Node ◽  
Interleukin 2 ◽  
Mesenteric Lymph ◽  
Heat Labile ◽  
Intestinal Pathogens ◽  
Lymph Node Cells ◽  
High Level ◽  
Humoral Responses

ABSTRACT Effective protection against intestinal pathogens requires both mucosal and systemic immune responses. Intranasal administration of antigens induces these responses but generally fails to trigger a strong protective immunity. Mucosal adjuvants can significantly enhance the immunogenicities of intranasally administered antigens. Cholera toxin (CT) and heat-labile enterotoxin (LT) are strong mucosal adjuvants with a variety of antigens. Moreover, the toxicities of CT and LT do not permit their use in humans. Two nontoxic mutant LTs, LTR72 and LTK63, were tested with Toxoplasma gondii SAG1 protein in intranasal vaccination of CBA/J mice. Vaccination with SAG1 plus LTR72 or LTK63 induced strong systemic (immunoglobulin G [IgG]) and mucosal (IgA) humoral responses. Splenocytes and mesenteric lymph node cells from mice immunized with LTR72 plus SAG1, but not those from mice immunized with LTK63 plus SAG1, responded to restimulation with a T. gondii lysate antigen in vitro. Gamma interferon and interleukin 2 (IL-2) production by splenocytes and IL-2 production by mesenteric lymph node cells were observed in vitro after antigen restimulation, underlying a Th1-like response. High-level protection as assessed by the decreased load of cerebral cysts after a challenge with the 76K strain of T. gondiiwas obtained in the group immunized with LTR72 plus SAG1 and LTK63 plus SAG1. They were as well protected as the mice immunized with the antigen plus native toxins. This is the first report showing protection against a parasite by using combinations of nontoxic mutant LTs and SAG1 antigen. These nontoxic mutant LTs are now attractive candidates for the development of mucosally delivered vaccines.

Evidence for the involvement of a bone marrow-derived cell population in the immune expulsion ofTrichinella spiralis

Parasitology ◽  
1977 ◽  
Vol 74 (3) ◽  
pp. 225-234 ◽  
Author(s):  
D. Wakelin ◽  
Margaret M. Wilson
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Cell Population ◽  
Mesenteric Lymph Node ◽  
Trichinella Spiralis ◽  
Mesenteric Lymph ◽  
Lymph Node Cells

When mice were irradiated immediately before infection withTrichinella spiralisthere was a profound and long-lasting interference with their ability to expel adult worms from the intestine. Irradiation given after the fifth day of infection was progressively less effective in this respect. The ability to expel worms was not restored when mesenteric lymph node cells (MLNC) were transferred (a) on the day of infection in mice irradiated one day previously, or (b) on day 7 of an infection in mice irradiated on day 6, even though the MLNC transferred immunity to intact recipients. Transfer of bone marrow (BM) alone was also without effect. However, worm explusion was restored if, following irradiation and injection of BM, 10 days were allowed for BM differentiation before transfer of MLNC. This restoration was effective even after lethal levels of irradiation and was clearly dependent upon a donor-derived BM component cooperating with, or responding to, the activity of the transferred MLNC. The possibility that the BM component is non-lymphoid in nature is discussed.

Dietary effects on insulin and nutrient metabolism in mesenteric lymph node cells, splenocytes, and pancreatic islets of BB rats

Metabolism ◽  
2000 ◽  
Vol 49 (9) ◽  
pp. 1111-1117 ◽  
Author(s):  
Fraser W. Scott ◽  
Elizabeth Olivares ◽  
Abdullah Sener ◽  
Willy J. Malaisse
Keyword(s):  
Lymph Node ◽  
Pancreatic Islets ◽  
Mesenteric Lymph Node ◽  
Nutrient Metabolism ◽  
Dietary Effects ◽  
Mesenteric Lymph ◽  
Bb Rats ◽  
Lymph Node Cells

scholarly journals Adoptive transfer of nontransgenic mesenteric lymph node cells induces colitis in athymic HLA-B27 transgenic nude rats

2006 ◽  
Vol 143 (3) ◽  
pp. 474-483 ◽  
Author(s):  
F. Hoentjen ◽  
S. L. Tonkonogy ◽  
B. Liu ◽  
R. B. Sartor ◽  
J. D. Taurog ◽  
...  
Keyword(s):  
Lymph Node ◽  
Adoptive Transfer ◽  
Mesenteric Lymph Node ◽  
Hla B27 ◽  
Mesenteric Lymph ◽  
Nude Rats ◽  
Lymph Node Cells

Specific cross-immunity between Trichinella spiralis and Trichuris muris: immunization with heterologous infections and antigens and transfer of immunity with heterologous immune mesenteric lymph node cells

Parasitology ◽  
1982 ◽  
Vol 84 (2) ◽  
pp. 381-389 ◽  
Author(s):  
T. D. G. Lee ◽  
R. K. Grencis ◽  
D. Wakelin
Keyword(s):  
Lymph Node ◽  
Mesenteric Lymph Node ◽  
Primary Infection ◽  
Trichinella Spiralis ◽  
The Other ◽  
Trichuris Muris ◽  
Mesenteric Lymph ◽  
Heterologous Challenge ◽  
Lymph Node Cells ◽  
Cross Immunity

SUMMARYInfections with either 300 infective Trichinella spiralis larvae or 400 embryonated eggs of Trichuris muris were effective in eliciting accelerated expulsion of heterologous challenge infections given 20 days after the primary infection. Accelerated expulsion could also be achieved by the administration of soluble crude worm antigen given 12 days prior to heterologous challenge or by adoptive transfer of mesenteric lymph node cells taken from mice infected with the heterologous parasite. Each species is capable of eliciting an accelerated secondary expulsion response in hosts that have been actively or adoptively immunized against the other species and these results are taken to indicate that there is a specific cross-immunity between T. spiralis and T. muris due to shared antigens. It is postulated that these shared antigens are derived from stichocyte granules.

Accelerated expulsion of adult Trichinella spiralis in mice given lymphoid cells and serum from infected donors

Parasitology ◽  
1976 ◽  
Vol 72 (3) ◽  
pp. 307-315 ◽  
Author(s):  
D. Wakelin ◽  
M. Lloyd
Keyword(s):  
Lymph Node ◽  
Mesenteric Lymph Node ◽  
Adult Stage ◽  
Trichinella Spiralis ◽  
Significant Degree ◽  
Lymphoid Cells ◽  
Mesenteric Lymph ◽  
Lymph Node Cells ◽  
Worm Expulsion

SummaryImmunity to the adult stage of Trichinella spiralis, assessed by an acceleration of worm expulsion, was transferred to recipient mice with mesenteric lymph node cells (MLNC) or serum taken from infected donors. Immunity was transferred most effectively by MLNC taken from donors infected for 8 days, i.e. donors actively responding to infection. Transfer of both MLNC and serum brought about a marked acceleration of worm expulsion in all cases, even where MLNC or serum given separately failed to transfer a significant degree of immunity.

scholarly journals Recombinant Proteins of Cryptosporidium parvum Induce Proliferation of Mesenteric Lymph Node Cells in Infected Mice

2005 ◽  
Vol 73 (8) ◽  
pp. 5245-5248 ◽  
Author(s):  
Inderpal Singh ◽  
Cynthia Theodos ◽  
Saul Tzipori
Keyword(s):  
Lymph Node ◽  
Immune Responses ◽  
Recombinant Proteins ◽  
Cryptosporidium Parvum ◽  
Mesenteric Lymph Node ◽  
Recombinant Antigens ◽  
Cellular Immune Responses ◽  
Mesenteric Lymph ◽  
Lymph Node Cells ◽  
Cellular Immune

ABSTRACT Recombinant antigens of Cryptosporidium parvum, Cp900 and Cp40 but not Cp15, stimulated C. parvum-specific proliferative immune responses of mesenteric lymph node cells in C57BL/6J mice infected with different isolates (MD, GCH1, UCP, and IOWA) of C. parvum, indicating that both Cp900 and Cp40 are immunodominant targets of cellular immune responses during C. parvum infection.

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