Predictive significance of physical and congnitive functions on admission to the rehabilitation facility for regaining of walking ability in patients with stroke

SummaryA double-blind, placebo-controlled randomized study with BAY U3405, a specific thromboxane A2 (TX A2) receptor blocker, was performed in patients suffering from severe stade II limb arteriopathy. BAY U3405 or placebo was administered in 16 patients at 20 mg four times a day (from day 1 to day 3). Hemostatic studies were done before therapy, and on day 2 and day 3 under therapy. On day 3, BAY U3405 was shown to induce a highly statistically significant decrease of the velocity and the intensity of the aggregations mediated by arachidonic acid (56 ± 37% for the velocity, 58 ± 26% for the intensity) or by U46619 endoperoxide analogue (36 ± 35% for the velocity, 37 ± 27% for the intensity). Similar results were already observed on day 2. By contrast, such a decrease was not noticed with ADP mediated platelet aggregation. Furthermore, plasma levels of betathrombo-globulin and platelet factor 4 remained unchanged. Peripheral hemodynamic parameters were also studied. The peripheral blood flow was measured using a Doppler ultrasound; the pain free walking distance and the total walking ability distance were determined under standardized conditions on a treadmill. These last two parameters show a trend to improvement which nevertheless was not statistically significant. All together these results encourage further in vivo studies using BAY U3405 or related compounds on a long-term administration.

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THE EFFECTS OF TREADMILL WALKING COMBINED WITH OBSTALCE-CROSSING ON WALKING ABILITY IN AMBULATORY PATIENTS AFTER STROKE: A PILOT RANDOMIZED CONTROLLED TRIAL

10.26226/morressier.58e389add462b802923854b6 ◽

2017 ◽

Author(s):

Jung-Wan Koo

Keyword(s):

Randomized Controlled Trial ◽

Controlled Trial ◽

Treadmill Walking ◽

Walking Ability ◽

Randomized Controlled ◽

Ambulatory Patients ◽

Pilot Randomized Controlled Trial

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Improving Walking Ability in Parkinson Disease

Case Medical Research ◽

10.31525/ct1-nct03921697 ◽

2019 ◽

Author(s):

Keyword(s):

Parkinson Disease ◽

Walking Ability

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Developing an Instrument for Measuring Walking Ability in Patients With Spinal Stenosis

Case Medical Research ◽

10.31525/ct1-nct04079894 ◽

2019 ◽

Author(s):

Keyword(s):

Spinal Stenosis ◽

Walking Ability

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Effects of Aging Process Exercise Program on Walking ability and Frailty of Elderly Women in Rural

Korean Journal of Sports Science ◽

10.35159/kjss.2018.04.27.2.1115 ◽

2018 ◽

Vol 27 (2) ◽

pp. 1115-1126 ◽

Cited By ~ 1

Author(s):

Seul-Hee Lee ◽

Ga-Ram Hong ◽

Bong-Jo Kim ◽

Eun-Hee Kim

Keyword(s):

Aging Process ◽

Elderly Women ◽

Exercise Program ◽

Walking Ability ◽

Effects Of Aging

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Using a saddle-assistive device equipped with mechanical orthosis for walking of the person with incomplete spinal cord injury

Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine ◽

10.1177/09544119211020146 ◽

2021 ◽

pp. 095441192110201

Author(s):

Akbar Hojjati Najafabadi ◽

Saeid Amini ◽

Farzam Farahmand

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Reaction Force ◽

Assistive Devices ◽

Assistive Device ◽

Walking Ability ◽

Vertical Force ◽

Incomplete Spinal Cord Injury ◽

Combined Application ◽

Cord Injury

The majority of the people with incomplete spinal cord injury lose their walking ability, due to the weakness of their muscle motors in providing torque. As a result, developing assistive devices to improve their conditionis of great importance. In this study, a combined application of the saddle-assistive device (S-AD) and mechanical medial linkage or thosis was evaluated to improve the walking ability in patients with spinal cord injury in the gait laboratory. This mobile assistive device is called the saddle-assistive device equipped with medial linkage or thosis (S-ADEM). In this device, a mechanical orthosis was used in a wheeled walker as previously done in the literature. Initially, for evaluation of the proposed assistive device, the experimental results related to the forces and torques exerted on the feet and upper limbs of a person with the incomplete Spinal Cord Injury (SCI) during walking usingthe standard walker were compared with an those obtained from using the S-ADEM on an able-bodied subject. It was found that using this combination of assistive devices decreases the vertical force and torque on the foot at the time of walking by 53% and 48%, respectively compared to a standard walker. Moreover, the hand-reaction force on the upper limb was negligible instanding and walking positions usingthe introduced device. The findings of this study revealed that the walking ability of the patients with incomplete SCI was improved using the proposed device, which is due to the bodyweight support and the motion technology used in it.

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Using a simple rope-pulley system that mechanically couples the arms, legs, and treadmill reduces the metabolic cost of walking

Journal of NeuroEngineering and Rehabilitation ◽

10.1186/s12984-021-00887-3 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Daisey Vega ◽

Christopher J. Arellano

Keyword(s):

Metabolic Cost ◽

Metabolic Energy ◽

Metabolic Effects ◽

Whole Body ◽

Walking Ability ◽

Arm Swing ◽

Pulley System ◽

Young Subjects ◽

Walking Recovery ◽

Set Up

Abstract Background Emphasizing the active use of the arms and coordinating them with the stepping motion of the legs may promote walking recovery in patients with impaired lower limb function. Yet, most approaches use seated devices to allow coupled arm and leg movements. To provide an option during treadmill walking, we designed a rope-pulley system that physically links the arms and legs. This arm-leg pulley system was grounded to the floor and made of commercially available slotted square tubing, solid strut channels, and low-friction pulleys that allowed us to use a rope to connect the subject’s wrist to the ipsilateral foot. This set-up was based on our idea that during walking the arm could generate an assistive force during arm swing retraction and, therefore, aid in leg swing. Methods To test this idea, we compared the mechanical, muscular, and metabolic effects between normal walking and walking with the arm-leg pulley system. We measured rope and ground reaction forces, electromyographic signals of key arm and leg muscles, and rates of metabolic energy consumption while healthy, young subjects walked at 1.25 m/s on a dual-belt instrumented treadmill (n = 8). Results With our arm-leg pulley system, we found that an assistive force could be generated, reaching peak values of 7% body weight on average. Contrary to our expectation, the force mainly coincided with the propulsive phase of walking and not leg swing. Our findings suggest that subjects actively used their arms to harness the energy from the moving treadmill belt, which helped to propel the whole body via the arm-leg rope linkage. This effectively decreased the muscular and mechanical demands placed on the legs, reducing the propulsive impulse by 43% (p < 0.001), which led to a 17% net reduction in the metabolic power required for walking (p = 0.001). Conclusions These findings provide the biomechanical and energetic basis for how we might reimagine the use of the arms in gait rehabilitation, opening the opportunity to explore if such a method could help patients regain their walking ability. Trial registration: Study registered on 09/29/2018 in ClinicalTrials.gov (ID—NCT03689647).

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Prediction of walking ability following posterior decompression for lumbar spinal stenosis

European Spine Journal ◽

10.1007/s00586-021-06938-6 ◽

2021 ◽

Author(s):

Suzanne McIlroy ◽

Feroz Jadhakhan ◽

David Bell ◽

Alison Rushton

Keyword(s):

Quality Of Life ◽

Higher Education ◽

Spinal Stenosis ◽

Lumbar Spinal Stenosis ◽

Walking Distance ◽

Walking Ability ◽

Poor Outcome ◽

Lumbar Spinal ◽

Reduced Risk

Abstract Purpose Following surgery for lumbar spinal stenosis (LSS) up to 40% of people report persistent walking disability. This study aimed to identify pre-operative factors that are predictive of walking ability post-surgery for LSS. Methods An observational cohort study was conducted using data from the British Spine Registry (2017–2018) of adults (≥ 50 years) with LSS, who underwent ≤ 2 level posterior lumbar decompression. Patients receiving fixation or who had previous lumbar surgery were excluded. Walking ability was assessed by a single item on the Oswestry Disability Index and dichotomised into poor/good outcome. Multivariable regression models were performed. Results 14,485 patients were identified. Pre-operatively 30% patients reported poor walking ability, this decreased to 8% at 12 months follow-up. Predictors associated with poor walking ability at 12 months were: increasing age (≥ 75 years OR 1.54, 95% CI 1.07, 2.18), BMI ≥ 35 kg/m2 (OR 1.52, 95% CI 1.00, 2.30), severity of leg pain (OR 1.10, CI 95% 1.01, 1.21), disability (OR 1.01, 95% CI 1.01, 1.02) and quality of life (OR 0.72, 95% CI 0.56, 0.89). Pre-operative maximum walking distance (OR 1.10, 95% CI 1.05, 1.25) and higher education (OR 0.90, 95% CI 0.80, 0.96) were associated with reduced risk of poor walking ability at 12 months; p < 0.05. Depression, fear of movement and symptom duration were not associated with risk of poor outcome. Conclusion Older age, obesity, greater pre-operative pain and disability and lower quality of life are associated with risk of poor walking ability post-operatively. Greater pre-operative walking and higher education are associated with reduced risk of poor walking ability post-operatively. Patients should be counselled on their risk of poor outcome and considered for rehabilitation so that walking and surgical outcomes may be optimised.

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Differences in Tibia Shape in Organically Reared Chicken Lines Measured by Means of Geometric Morphometrics

Animals ◽

10.3390/ani11010101 ◽

2021 ◽

Vol 11 (1) ◽

pp. 101

Author(s):

Domitilla Pulcini ◽

David Meo Zilio ◽

Francesco Cenci ◽

Cesare Castellini ◽

Monica Guarino Amato

Keyword(s):

Geometric Morphometrics ◽

Body Weight Gain ◽

Growth Speed ◽

Walking Ability ◽

Static Behavior ◽

Walking Behavior ◽

Organic Farm ◽

Genetic Types ◽

External Reference ◽

Slow Growing

In the present study, the conformation of the tibia of seven genetic lines of broilers was analyzed by Geometric Morphometrics and correlated to carcass weight and walking ability. The used chicken genetic lines were classified as fast, medium, or slow growing and ranked for their walking ability. Six chicken types were reared in an organic farm and slaughtered at 81 days of age while one slow-growing and highly walking line (Naked Neck) was reared in a commercial farm and used as external reference for moving activity and growth speed. A mixed landmarks and semi-landmarks model was applied to the study of tibia shape. Results of this study showed that: (i) body weight gain was positively correlated to the curvature of the antero-posterior axis of the tibia; (ii) the shape of the tibia and the active walking behavior were significantly correlated; (iii) walking and not-walking genetic lines could be discriminated in relation to the overall shape of the tibia; (iv) a prevalence of static behavior was correlated to a more pronounced curvature of the antero-posterior axis of the tibia. Results of this study revealed that the walking genetic types have a more functional and natural tibia conformation. This easy morphologic method for evaluating tibia shape could help to characterize the adaptability of genotypes to organic and outdoor rearing.

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