scholarly journals Effects of treadmill exercise on activity, short-term memory, vascular dysfunction in maternal separation rats

2020 ◽  
Vol 16 (2) ◽  
pp. 118-123 ◽  
Author(s):  
Sang-Seo Park ◽  
Tae-Woon Kim ◽  
Hye-Sang Park ◽  
Tae-Beom Seo ◽  
Young-Pyo Kim
Keyword(s):  
Maternal Separation ◽  
Short Term Memory ◽  
Treadmill Exercise ◽  
Vascular Dysfunction ◽  
Short Term ◽  
Term Memory

Treadmill exercise improves short-term memory by suppressing ischemia-induced apoptosis of neuronal cells in gerbils

2004 ◽  
Vol 372 (3) ◽  
pp. 256-261 ◽  
Author(s):  
Young-Je Sim ◽  
Sung-Soo Kim ◽  
Jee-Youn Kim ◽  
Mal-Soon Shin ◽  
Chang-Ju Kim
Keyword(s):  
Short Term Memory ◽  
Treadmill Exercise ◽  
Neuronal Cells ◽  
Short Term ◽  
Term Memory ◽  
Induced Apoptosis

scholarly journals Treadmill exercise improves short-term memory by enhancing neurogenesis in amyloid beta-induced Alzheimer disease rats

2014 ◽  
Vol 10 (1) ◽  
pp. 2-8 ◽  
Author(s):  
Bo-Kyun Kim ◽  
Mal-Soon Shin ◽  
Chang-Ju Kim ◽  
Sang-Bin Baek ◽  
Yeong-Chan Ko ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Amyloid Beta ◽  
Short Term Memory ◽  
Treadmill Exercise ◽  
Short Term ◽  
Term Memory

scholarly journals Forced exercise activates the NrF2 pathway in the striatum and ameliorates motor and behavioral manifestations of Parkinson's disease in rotenone-treated rats

2020 ◽  
Author(s):  
Dina Monir ◽  
Motamed Mahmoud ◽  
Omyma Galal ◽  
Ibrahim Rehan ◽  
Amany Abdelrahman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopaminergic Neurons ◽  
Short Term Memory ◽  
Treadmill Exercise ◽  
Neurodegenerative Disorder ◽  
Short Term ◽  
Term Memory ◽  
Nrf2 Pathway

Abstract Background: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive loss of nigrostriatal dopaminergic neurons leading to dopamine depletion and problems of movement, emotions and cognition. While the pathogenesis of PD is not clear, damage of dopaminergic neurons by oxygen-derived free radicals is considered an important contributing mechanism.This study aimed to evaluate the role of treadmill exercise in male Wister rats as a single treatment and as an aid-therapy with L-dopa for rotenone-induced PD. To study the role of NRF2-ARE pathway as a mechanism involved in exercise associated improvement in rotenone rat model of PD.Method: Animals were divided into 5 groups, (Control, rotenone, rotenone\exercise, rotenone\L-dopa, and rotenone\exercise\L-dopa (combination) groups). After the PD induction, rats in the rotenone\exercise and combination groups were daily treadmill exercised for 4 weeks.Results: Treadmill exercise significantly improved behavioral and motor aspects of rotenone model of PD. When treadmill exercise introduced as a single intervention, it amended most behavioral aspects of PD, gait fully corrected, short-term memory, and motor coordination. Where L-dopa corrected locomotor activity and motor co-ordination but failed to improve short-term memory and only partially corrected the gait of rotenone-treated rats. When treadmill exercise was combined with L-dopa, all features of PD were corrected. It was found that exercise upregulated some of its associative genes to NRF2 pathways such as TFAM, NRF2, Noq.1 mRNA expression.Conclusion: This study suggests that forced exercise improved parkinsonian like features by activating NRF2 pathway.

scholarly journals Effects of treadmill exercise-intensity on short-term memory in the rats born of the lipopolysaccharide-exposed maternal rats

2015 ◽  
Vol 11 (6) ◽  
pp. 296-302 ◽  
Author(s):  
Kijeong Kim ◽  
Yun-Hee Sung ◽  
Jin-Hee Seo ◽  
Sang-Won Lee ◽  
Baek-Vin Lim ◽  
...  
Keyword(s):  
Exercise Intensity ◽  
Short Term Memory ◽  
Treadmill Exercise ◽  
Short Term ◽  
Term Memory

scholarly journals Forced exercise activates the NrF2 pathway in the striatum and ameliorates motor and behavioral manifestations of Parkinson's disease in rotenone-treated rats

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Dina M. Monir ◽  
Motamed E. Mahmoud ◽  
Omyma G. Ahmed ◽  
Ibrahim F. Rehan ◽  
Amany Abdelrahman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopaminergic Neurons ◽  
Motor Coordination ◽  
Short Term Memory ◽  
Treadmill Exercise ◽  
Short Term ◽  
Term Memory ◽  
Nrf2 Pathway

Abstract Background Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive loss of nigrostriatal dopaminergic neurons leading to dopamine depletion and problems of movement, emotions, and cognition. While the pathogenesis of PD is not clear, damage of dopaminergic neurons by oxygen-derived free radicals is considered an important contributing mechanism. This study aimed to evaluate the role of treadmill exercise in male Wister rats as a single treatment and as an aid-therapy with L-dopa for rotenone-induced PD. To study the role of the Nrf2- ARE pathway as a mechanism involved in exercise-associated improvement in rotenone-induced PD in rats. Method Animals were divided into 5 groups, (Control, rotenone, rotenone\exercise, rotenone\L-dopa, and rotenone\exercise\L-dopa (combination)groups). After the PD induction, rats in the rotenone\exercise and combination groups were daily treadmill exercised for 4 weeks. Results Treadmill exercise significantly improved behavioral and motor aspects of rotenone-induced PD. When treadmill exercise was introduced as a single intervention, it amended most behavioral aspects of PD, gait fully corrected, short-term memory, and motor coordination. Where L-dopa corrected locomotor activity and motor coordination but failed to improve short-term memory and only partially corrected the gait of rotenone-treated rats. When treadmill exercise was combined with L-dopa, all features of PD were corrected. It was found that exercise upregulated some of its associative genes to Nrf2 pathways such as TFAM, Nrf2 and NQO.1 mRNA expression. Conclusion This study suggests that forced exercise improved parkinsonian like features by activating the Nrf2 pathway.

scholarly journals Treadmill Exercise Improves Motor Function and Short-term Memory by Enhancing Synaptic Plasticity and Neurogenesis in Photothrombotic Stroke Mice

2020 ◽  
Vol 24 (Suppl 1) ◽  
pp. S28-38
Author(s):  
Minha Hong ◽  
Mia Kim ◽  
Tae-Woon Kim ◽  
Sang-Seo Park ◽  
Myung-Ki Kim ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Motor Function ◽  
Dendritic Spines ◽  
Short Term Memory ◽  
Treadmill Exercise ◽  
Postsynaptic Density ◽  
Short Term ◽  
Term Memory ◽  
Photothrombotic Stroke ◽  
Postsynaptic Density Protein

Purpose: Thrombotic stroke is a type of ischemic stroke characterized by motor dysfunction and memory impairments. In the present study, the effect of treadmill exercise on motor function and short-term memory was evaluated in relation with synaptic plasticity in the mice with photothrombotic stroke.Methods: Photothrombotic stroke was induced by cortical photothrombotic vascular occlusion. The mice in the treadmill exercise groups performed running on a motorized treadmill for 28 days. Motor function was determined using rota-rod test and foot fault test. Step-through avoidance task was conducted to evaluate short-term memory. Immunohistochemistry for 5-bromo-2′-deoxyuridine and doublecortin was conducted to detect new cell generation. Postsynaptic density protein 95, synaptophysin, brain-derived neurotrophic factor (BDNF), and tyrosine kinase B receptor (TrkB) were determined using western blot. The number of dendritic spines was determined using Golgi stain.Results: Treadmill exercise improved motor function and short-term memory in mice with the photothrombotic stroke. The infarct size was reduced and the number of dendritic spines and expression of postsynaptic density protein 95 and synaptophysin in the peri-infarct cortex and hippocampus were increased by treadmill exercise in photothrombotic stroke mice. Treadmill exercise enhanced neurogenesis through increasing the expression of the hippocampal BDNF and TrkB in photothrombotic stroke mice.Conclusions: Treadmill exercise improved motor function and short-term memory through increasing synaptic plasticity and neurogenesis in photothrombotic stroke mice. Treadmill exercise can be used as an effective treatment strategy to improve brain function related to stroke.

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