Serum TNF Alpha as a Non-Invasive Marker for Diagnosing Biliary Atresia

2017 ◽  
Vol 5 ◽  
pp. 1-6
Author(s):  
Haidy Zakaria ◽  
Keyword(s):  
Biliary Atresia ◽  
Tnf Alpha ◽  
Non Invasive

scholarly journals Increased Serum Levels of Activated Caspases in Murine and Human Biliary Atresia

2021 ◽  
Vol 10 (12) ◽  
pp. 2718
Author(s):  
Omid Madadi-Sanjani ◽  
Gunnar Bohlen ◽  
Fabian Wehrmann ◽  
Julia Andruszkow ◽  
Karim Khelif ◽  
...  
Keyword(s):  
Liver Injury ◽  
Biliary Atresia ◽  
Caspase 3 ◽  
Serum Levels ◽  
Healthy Individuals ◽  
Serological Detection ◽  
Caspase Activation ◽  
Hepatocyte Apoptosis ◽  
Non Invasive ◽  
Cholestatic Diseases

In biliary atresia (BA), apoptosis is part of the pathomechanism, which results in progressive liver fibrosis. There is increasing evidence suggesting that apoptotic liver injury can be non-invasively detected by measuring the caspase activity in the serum. The purpose of this study was to investigate whether serological detection of caspase activation mirrors apoptotic liver injury in the infective murine BA-model and represents a suitable biomarker for BA in humans. Analysis showed increased caspase-3 activity and apoptosis in the livers of cholestatic BALB/c mice, which correlated significantly with caspase activation in the serum. We then investigated caspase activation and apoptosis in liver tissues and sera from 26 BA patients, 23 age-matched healthy and 11 cholestatic newborns, due to other hepatopathies. Compared to healthy individuals, increased caspase activation in the liver samples of BA patients was present. Moreover, caspase-3 activity was significantly higher in sera from BA infants compared to patients with other cholestatic diseases (sensitivity 85%, specificity 91%). In conclusion, caspase activation and hepatocyte apoptosis play an important role in experimental and human BA. We demonstrated that serological detection of caspase activation represents a reliable non-invasive biomarker for monitoring disease activity in neonatal cholestatic liver diseases including BA.

Measurement of serum TNF alpha as a sensitive and specific marker in diagnosing extrahepatic biliary atresia

2014 ◽  
Vol 33 (5) ◽  
pp. 482-483 ◽  
Author(s):  
Mohammadreza Fariborzi ◽  
Fatemeh Farahmand ◽  
Gholamhosein Fallahi ◽  
Mohammadtaghi Ashtyani ◽  
Masumeh Hashemi ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Tnf Alpha ◽  
Specific Marker ◽  
Extrahepatic Biliary Atresia

Personalized mathematical model of endotoxin-induced inflammatory responses in young men and associated changes in heart rate variability

2018 ◽  
Vol 13 (5) ◽  
pp. 42 ◽  
Author(s):  
R. Brady ◽  
D.O. Frank-Ito ◽  
H.T. Tran ◽  
S. Janum ◽  
K. Møller ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Inflammatory Responses ◽  
Interleukin 10 ◽  
Tnf Alpha ◽  
Non Invasive ◽  
Estimated Parameters ◽  
Subject Specific ◽  
The Subject ◽  
Necrosis Factor

The objective of this study was to develop a personalized inflammatory model and estimate subject-specific parameters that could be related to changes in heart rate variability (HRV), a measure that can be obtained non-invasively in real time. An inflammatory model was developed and calibrated to measurements of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), interleukin-8 (IL-8) and interleukin-10 (IL-10) over 8 hours in 20 subjects administered a low dose of lipopolysaccharide. For this model, we estimated 11 subject-specific parameters for all 20 subjects. Estimated parameters were correlated with changes in HRV, computed from ECG measurements using a built-in HRV module available in Labchart. Results revealed that patients could be separated into two groups expressing normal and abnormal responses to endotoxin. Abnormal responders exhibited increased HRV, most likely as a result of increased vagal firing. The observed correlation between the inflammatory response and HRV brings us a step further towards understanding if HRV predictions can be used as a marker for inflammation. Analyzing HRV parameters provides an easy, non-invasively obtained measure that can be used to assess the state of the subject, potentially translating to identifying a non-invasive marker that can be used to detect the onset of sepsis.

Non-invasive urinary metabolomic profiles discriminate biliary atresia from infantile hepatitis syndrome

Metabolomics ◽  
2018 ◽  
Vol 14 (7) ◽  
Author(s):  
Wei-Wei Li ◽  
Yan Yang ◽  
Qi-Gang Dai ◽  
Li-Li Lin ◽  
Tong Xie ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Non Invasive ◽  
Infantile Hepatitis Syndrome

OC.03.8 CAN NON-INVASIVE METHODS PREDICT ESOPHAGEAL VARICES IN CHILDREN WITH BILIARY ATRESIA AFTER KASAI OPERATION?

2010 ◽  
Vol 42 ◽  
pp. S78
Author(s):  
A. Di Biase ◽  
E. Scaioli ◽  
A. Colecchia ◽  
V. Spezzani ◽  
S. Cipolli ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Esophageal Varices ◽  
Non Invasive ◽  
Kasai Operation

Assessment of native liver fibrosis using ultrasound elastography and serological fibrosis indices in children with biliary atresia after the Kasai procedure

2020 ◽  
pp. 028418512094848
Author(s):  
Jisun Hwang ◽  
Hee Mang Yoon ◽  
Kyung Mo Kim ◽  
Seak Hee Oh ◽  
Jung-Man Namgoong ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Fibrosis ◽  
Liver Function ◽  
Diagnostic Accuracy ◽  
Biliary Atresia ◽  
Non Invasive ◽  
Kasai Procedure ◽  
Serologic Markers ◽  
Native Liver ◽  
Us Elastography

Background Validated non-invasive examinations are necessary to monitor liver fibrosis in children with biliary atresia (BA) after the Kasai procedure. Purpose To evaluate the diagnostic accuracy of two-dimensional shear wave elastography (2D-SWE), transient elastography (TE), and the serologic biomarkers of aspartate transaminase-to-platelet ratio index (APRI) and Fibrosis-4 (FIB-4) score for evaluating native liver fibrosis in children with BA. Material and Methods We retrospectively reviewed same-day 2D-SWE and TE liver stiffness (LS) measurements of 63 patients with BA who underwent the Kasai procedure. The APRI and FIB-4 score were computed. Hepatic fibrosis was categorized into three clinical categories based on the ultrasound (US) hepatic morphology and clinical manifestations of liver cirrhosis: I, pre-cirrhotic liver state (n = 15); II, US and/or clinical signs of liver cirrhosis with compensated liver function (n = 27); and III, liver cirrhosis with decompensated liver function (n = 21). We compared area under the receiver operating characteristic curve (AUC) data among 2D-SWE, TE, APRI, and FIB-4 score. Combined evaluation of serologic fibrosis indices and US elastography was conducted and AUCs of combinations were analyzed. Results 2D-SWE, TE, APRI, and FIB-4 score showed good to excellent diagnostic accuracy for differentiating clinical categories (AUCs 0.779–0.955). AUC values were significantly increased after adding TE to FIB-4 score for detecting liver cirrhosis ( P = 0.02). Conclusion 2D-SWE, TE, APRI, and FIB-4 score are accurate non-invasive markers for monitoring native liver fibrosis in patients with BA. Combined use of serologic markers and US elastography could yield more accurate diagnoses of liver fibrosis than serologic markers alone.

F.N.4 CAN NON-INVASIVE METHODS PREDICT ESOPHAGEAL VARICES IN CHILDREN WITH BILIARY ATRESIA AFTER KASAY OPERATION?

2010 ◽  
Vol 42 ◽  
pp. S34
Author(s):  
A. Colecchia ◽  
A.R. Di Biase ◽  
E. Scaioli ◽  
V. Spezzani ◽  
S. Cipolli ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Esophageal Varices ◽  
Non Invasive
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