Nondestructive Early Detection of Bruising in Pear Fruit Using Optical Coherence Tomography

2019 ◽  
Vol 37 (1) ◽  
Keyword(s):  
Optical Coherence Tomography ◽  
Early Detection ◽  
Optical Coherence ◽  
Pear Fruit

scholarly journals FRI0226 OPTICAL COHERENCE TOMOGRAPHY OF THE SKIN DETECTS SCLERODERMA CHANGES IN CLINICALLY UNAFFECTED SKIN: AN OPPORTUNITY FOR EARLY DETECTION OF SYSTEMIC SCLEROSIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 696.2-696
Author(s):  
G. Abignano ◽  
D. Temiz Karadağ ◽  
O. Gundogdu ◽  
G. Lettieri ◽  
M. C. Padula ◽  
...  
Keyword(s):  
At Risk ◽  
Clinical Trials ◽  
Optical Coherence Tomography ◽  
Systemic Sclerosis ◽  
Early Detection ◽  
Classification Criteria ◽  
Healthy Controls ◽  
Optical Coherence ◽  
Risk Patients ◽  
Unaffected Skin

Background:The Very Early Diagnosis Of Systemic Sclerosis (VEDOSS) study has shown that 82% of patients with Raynaud’s Phenomenon, specific ANA positivity and scleroderma pattern at nail fold videocapillaroscopy will fulfil classification criteria within 5 years. This is suggesting that there is a subclinical window of opportunity to diagnose systemic sclerosis (SSc) before clinical manifestations occur. In this scenario, a non-invasive tool to diagnose SSc in clinically unaffected skin might improve the early detection of disease in at risk-patients. Optical coherence tomography (OCT) of the skin has been shown to be a sensitive and accurate biomarker of skin fibrosis in SSc.Objectives:Here we aimed to assess the ability of skin OCT to “detect” SSc in clinically unaffected skin from a multicentre cohort.Methods:Dorsal forearm skin of SSc patients and matched-healthy controls (HC) was evaluated using VivoSight scanner (Michelson Diagnostics). Mean A-scans (mean OCT signal plotted against depth-in-tissue) were derived as previously described. Minimum Optical Density (MinOD), Maximum OD (MaxOD) and OD at 300 micron-depth (OD300) were calculated. Clinical involvement was assessed by an operator blinded to OCT findings using the mRSS. Receiver-operating characteristic (ROC) curve analysis was carried out for MinOD, MaxOD, and OD300 to evaluate their ability to discriminate between SSc and HC. Statistical analysis was performed using GraphPad Prism software V.7.0.Results:One hundred seventy four OCT images were collected from 87 subjects [43 SSc (39 Female, mean age 49.7±9.1 years) and 44 gender/age-matched healthy controls (HC) (36 Female, mean age 50.2±8.3 years)] in two different SSc centres. All patients fulfilled classification criteria for SSc. OCT measures demonstrated discriminative ability in SSc skin detection with any clinical skin involvement (0-3 at site of analysis) with an AUC of 0.73 (MinOD, 95%CI 0.64-0.81), 0.77 (MaxOD, 95%CI 0.7-0.85) and 0.82 (OD300, 95%CI 0.76-0.89); p<0.0001 for all as previously indicated. Most importantly, all three measures showed comparable performance in detecting scleroderma also in clinically unaffected skin (mRss=0 at site of analysis), with an AUC of 0.7 (95%CI 0.6-0.81, p=0.001), 0.72 (95%CI 0.61-0.83, p=0.0003) and 0.72 (95%CI 0.61-0.83, p=0.0003) for MinOD, MaxOD and OD300 respectively.Conclusion:Virtual biopsy by OCT recognises clinically unaffected skin of SSc patients from the HC skin. This is consistent with gene array data showing that scleroderma specific signatures are consistent in affected and clinically unaffected skin. These results inform future studies on at risk patients with clinically unaffected skin which may define a role for OCT in detecting subclinical SSc.Disclosure of Interests:Giuseppina Abignano: None declared, Duygu Temiz Karadağ: None declared, Ozcan Gundogdu: None declared, Giovanni Lettieri: None declared, Maria Carmela Padula: None declared, Angela Padula: None declared, Paul Emery Grant/research support from: AbbVie, Bristol-Myers Squibb, Merck Sharp & Dohme, Pfizer, Roche (all paid to employer), Consultant of: AbbVie (consultant, clinical trials, advisor), Bristol-Myers Squibb (consultant, clinical trials, advisor), Lilly (clinical trials, advisor), Merck Sharp & Dohme (consultant, clinical trials, advisor), Novartis (consultant, clinical trials, advisor), Pfizer (consultant, clinical trials, advisor), Roche (consultant, clinical trials, advisor), Samsung (clinical trials, advisor), Sandoz (clinical trials, advisor), UCB (consultant, clinical trials, advisor), Salvatore D’Angelo: None declared, Francesco Del Galdo: None declared

scholarly journals Short wave–automated perimetry (SWAP) versus optical coherence tomography in early detection of glaucoma [Corrigendum]

2018 ◽  
Vol Volume 12 ◽  
pp. 2313-2314
Author(s):  
Adel Galal Zaky ◽  
Ahmed Tarek Yassin ◽  
Saber Hamed El Sayid
Keyword(s):  
Optical Coherence Tomography ◽  
Early Detection ◽  
Short Wave ◽  
Automated Perimetry ◽  
Optical Coherence

scholarly journals In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography

2009 ◽  
Vol 14 (6) ◽  
pp. 060503 ◽  
Author(s):  
Jiechen Yin ◽  
Gangjun Liu ◽  
Jun Zhang ◽  
Lingfeng Yu ◽  
Sari Mahon ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Early Detection ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Swept Source ◽  
Airway Injury

scholarly journals Early detection of retinal changes in patients using hydroxychloroquine – An optical coherence tomography-based study

2020 ◽  
Vol 32 (1) ◽  
pp. 60
Author(s):  
Aiswarya Sasidharan ◽  
AnthrayosC.V. Kakkanatt ◽  
Mercy Paul ◽  
Francy Louis ◽  
Arino John
Keyword(s):  
Optical Coherence Tomography ◽  
Early Detection ◽  
Optical Coherence

The Validity of Optical Coherence Tomography Angiography as a Screening Test for the Early Detection of Retinal Changes in Patients with Hydroxychloroquine Therapy

2018 ◽  
Vol 44 (3) ◽  
pp. 311-315 ◽  
Author(s):  
Yasin Sakir Goker ◽  
Cemile Ucgul Atılgan ◽  
Kemal Tekin ◽  
Hasan Kızıltoprak ◽  
Esat Yetkin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Early Detection ◽  
Screening Test ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence

Spectroscopic optical coherence tomography for early detection of colorectal cancer in a mouse model

2021 ◽  
Author(s):  
Wesley Y. Kendall ◽  
Julianna Bordas ◽  
Evan T. Jelly ◽  
Babak Mirminachi ◽  
Abel Joseph ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Optical Coherence Tomography ◽  
Early Detection ◽  
Mouse Model ◽  
Optical Coherence
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