Improved Oral Pharmacokinetics of Diclofenac Sodium from SNEDDS in Human Volunteers

2016 ◽  
Vol 3 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Gannu Kumar ◽  
◽  
Devaraj Rambhau ◽  
Shashank Apte
Keyword(s):  
Diclofenac Sodium ◽  
Human Volunteers ◽  
Oral Pharmacokinetics

Influence of Simulated Weightlessness on the Intramuscular and Oral Pharmacokinetics of Promethazine in 12 Human Volunteers

2006 ◽  
Vol 46 (9) ◽  
pp. 1008-1016 ◽  
Author(s):  
Peggy Gandia ◽  
Sylvie Saivin ◽  
Anne Pavy Le-Traon ◽  
Antonio Guell ◽  
Georges Houin
Keyword(s):  
Simulated Weightlessness ◽  
Human Volunteers ◽  
Oral Pharmacokinetics

Invitro cell membrane stability study of methanol and aqueous extract of Begonia trichocarpa Dalzell

2020 ◽  
Vol 10 (2) ◽  
pp. 28-32
Author(s):  
Jeyasekhar M P ◽  
Jaslin Edward J
Keyword(s):  
Aqueous Extract ◽  
Blood Test ◽  
Methanol Extract ◽  
Cell Layer ◽  
Diclofenac Sodium ◽  
Stability Study ◽  
Cell Membrane Stability ◽  
Human Volunteers ◽  
Present Evaluation ◽  
Standard Medication

The point of present evaluation was to decide the layer balancing out impact of methanol and aqueous extract of Begonia trichocarpa on human red platelet (RBC) film. It was an invitro determination, where blood test was collected from the human volunteers and particular concentrations were made by weakening with supports. The cell suspensions were presented to 100 to 1000 μg/mL arrangement of methanol and aqueous extracts of Begonia trichocarpa. Cell film strength was broke down with various conditions like change in temperature and pH. Diclofenac sodium was utilized as standard medication. Every grouping of concentrates was performed in a triplicate way and the information were determined and introduced as Mean with standard deviation. Film settling exercises were altogether higher with cells which were presented to methanol concentrate of Begonia trichocarpa than fluid concentrate. The restraint of cell film break was focus dependent. This evaluation results demonstrated that the two concentrates has cell layer balancing out action on human RBC however methanol extract was powerful than fluid concentrate. Study report proposed that Begonia trichocarpa plant extracts may offer some helpful impacts in the management inflammatory mediators.

Oral Pharmacokinetics of Fluazifop-Butyl in Human Volunteers

1991 ◽  
Vol 10 (1) ◽  
pp. 39-43 ◽  
Author(s):  
B.H. Woollen ◽  
T.B. Hart ◽  
P.L. Batten ◽  
W.J.D. Laird ◽  
D.S. Davies ◽  
...  
Keyword(s):  
Body Weight ◽  
Active Ingredient ◽  
Half Life ◽  
Pharmacokinetic Model ◽  
Serum Proteins ◽  
Peak Plasma ◽  
Plasma Concentrations ◽  
Elimination Half ◽  
Human Volunteers ◽  
Oral Pharmacokinetics

1 Fluazifop-butyl, the active ingredient of FUSILADE, a selective herbicide, was administered orally to three male volunteers at a dose level of 0.07 mg kg-1 body weight. Over a period of 6 d between 80 and 93% of the dose was excreted in urine as the metabolite fluazifop, the majority within the first 24 h. Peak plasma concentrations of fluazifop occurred 1-2.5 h after administration. 2 The elimination of fluazifop from plasma and urine can be described by a one-compartment pharmacokinetic model and the elimination half-life was estimated from blood and urine data to be within the range 9-37 h. Fluazifop was found to bind to serum proteins. 3 The study indicates that the amount of fluazifop-butyl absorbed in exposed persons can be assessed by measuring fluazifop concentrations in urine.

Release behaviour of diclofenac sodium dispersed in Gelucire® and encapsulated with alginate beads

2008 ◽  
pp. 1-4
Author(s):  
Bashar Al-Taani ◽  
Mai Khanfar ◽  
Mutaz Sheikh Salem ◽  
Alsayed Sallam
Keyword(s):  
Diclofenac Sodium ◽  
Alginate Beads
Sign in / Sign up

Export Citation Format

Share Document