Evaluation of Drug Utilisation Pattern and Clinical Presentation in Covid19 Patients Based on the Disease Severity

Coronavirus disease of 2019 (COVID-19) is an extremely communicable disease characterized by the serious acute respiratory influenza virus 2, a recently identified novel viral disease (SARS-CoV-2). Hitherto, the quantity of established instances worldwide has reached 135 million, and the number of deaths is 2.9 million. In India, the cases were found to be 20 million and the mortality rate is 3,51,000. This virus was first identified in Wuhan City, Hubei Province in China, at the end of 2019. Until now, it affected more than 200 countries. The treatment pattern and clinical presentations were assessed in COVID 19 patients. A total of 146 patients, severe patients (n = 71) and non-severe patients (n = 75) where included in the study. The mean age of the study population was found to be 58.76±14.32 and the most common symptoms of patients include fever, fatigue, dry cough, and diarrhea there is no statistically significant difference in the clinical features between severe and non-severe patients. There is no significant difference in the laboratory findings except lymphocyte count, CORADS and N/L ratio between severe and non-severe patients. COVID-19 affects all age groups especially the elderly. The risk for severe illness with COVID-19 increases with age. COVID 19 patients were presented with various the risk factors and the clinical features in the severe and non severe conditions patients, our study shows great significance to prevent the patient turning to critical condition during diagnosis and treatment.

A study on Private Car Accidents

In this study, road traffic injury (RTI) was defined as any injury resulting from a road traffic accident irrespective of severity and outcome. Road traffic accident (RTA) was defined as any crash on the road involving at least one moving vehicle, irrespective of it resulting in an injury. This could include collision with a vehicle or any non`moving object while driving/riding a vehicle, collision with a moving vehicle while walking/running/standing/ sitting on the road, or fall from a moving vehicle. The burden of road traffic accidents (RTA) is a leading cause of all trauma admissions in hospitals worldwide. Road traffic injuries cause considerable economic losses to victims, their families, and to nations as a whole. These losses arise from the cost of treatment (including rehabilitation and incident investigation) as well as reduced/lost productivity (e.g. in wages) for those killed or disabled by their injuries and for family members who need to take time off work (or school) to care for the injured. Road traffic fatality in the Kingdom of Saudi Arabia (KSA) is the highest, accounts for 4.7% of all mortalities. Road injuries also are reported to be the most serious in this country, with an accident to injury ratio of 8:6. In this study, we try to focus on some causes of the accidents in KSA, so we can implement the prevention plan.

Effect of antioxidant activity of basella on convulsions mediated enzymes

Seizures and epilepsy are inter-related conditions that are often seen in the patients with neurological conditions. In general there are various types of epilepsies like the grand mal, petit mal and clonic tonic types. Typically epilepsies are caused due to the oxidative free radicals that are generated in the brain. There are numerous investigations and researches that are carried out in this field to prove that the oxidative stress and free radicals are the primary etiology for the brain damage and epilepsy. The epilepsy and seizures are often evaluated with the elevation or variations in the brain enzymes. Herbs are few of those drugs that contain rich antioxidants and chemicals. There had been numerous investigations that were performed to prove the activities. They also contain chemicals like Vitamins, polyphenols, flavonoids, alkaloids etc. that posess the activity on brain. In this study, formulations were prepared using the extracts of Basella alba, Bacopa moneira. The effect of these formulations on the antioxidant levels in the brain are estimated and compared to the standard formulation Saraswathiaristam formulation. The formulations showed a better activity compared to the standard ayurvedic formulation. The prevention of tissue damage was estimated by determining the antioxidant enzyme levels.

Simultaneous estimation of simvstatin and piperine in its formulation by UV spectrophotometric method

The active ingredient, called piperine, is present in black pepper. The ions are very small so they are easily consumed by the tissue and nervous system, causing the chemical release within the brain. Piperine has been shown to help ease gastrointestinal ailments, help with vomiting, and has the ability to help with inflammation of the body. This explains to us how simvastatin can help expedite piperine in the body. The new, clear, effective, quick, accurate ultraviolet spectrophotometric method has to be validated and developed for the study of simvastatin and piperine in bulk and poly-herbal formulations. Data from validation experiments was tested using methodological techniques. Since processing at a wavelength of 285nm, the standard solution appeared to have a far higher absorbance than at other wavelengths. Normal simvastatin and piperine have been measured in varying amounts, and they make spectrums of overlays. In Beer Law, the concentration (C) of a solvent is plotted against the absorbance (A) from a calibration curve, as a result. A linearity range of between 14and 39μg/mL was observed. The sample was tested by prorating the standard deviation and standard error of the approximate means with the sample size, demonstrating the accuracy and the precision of the methods used in the analysis. Based on the experimental findings, it can be easily inferred that for UV spectrometry estimation of simvastatin and piperine from pharmaceutical intravenous liquid formulation, the proposed method is very simple, fast, accurate, precise, economical and reproducible.

Invivo Activity of Polyherbal Gels Prepared Using Carbopol

Pain and inflammation are the basic defense responses of the body that the result of the injury and any other damage to the body. During the years the concerns were raised towards the inflammation that is caused to the oxidative damage that is resulted in the physiological stress due to oxidation. There are a lot of drugs that are used to treat the condition effectively and the typical examples are NSAID’s and SAID’s which have a noted mechanism to show the anti-inflammatory activity. They have serious problems with the side effects like Gastrointestinal irritation, Gastric pain, Gastric perforations and peptic ulcers. Herbs have been used as better alternatives that are used to treat diseases. The significance of the medicinal plants had been emphasized significantly in tradition rich countries like India and all over the world. The research proof of those herbs for their activities and their traditional claims were proven. Poly Herbal Gels were prepared using the root extracts of the plant Corchorus olitorius. The gels were prepared using the Carbopol 940 and the prepared gels were investigated for their anti-inflammatory property and the gels showed a significantly better activity compared to the plant extract and the standard drug too. The addition of other drugs in to the gels added and advantage to the increase in the activity and faster onset of action as the gel was applied directly in the place of the inflammation.

Isolation and characterization of oleochemical compounds from watermelon seed

The common watermelon item (Citrullus lanatus) seeds were gained from castoffs verdant nourishments for use by decorating, sun ventilation and pulverizing. Light yellow-toned oil was gotten by dissolvable withdrawal using oil atmosphere and the going with traits were gotten using oil ether: pH, refractive rundown, thickness, dissolvable miscibility, coagulating temperature, fire nature, express gravity, streak point and warmth of consuming. With a shallow level of unsaturation, stepped level of smoothness, and proximity of raised degree of the sensible proportion of free unsaturated fats. The low assessment of the solidifying temperature of the oil offered a hint that the oil can be managed in various areas paying little heed to the qualification in temperature. The following level of linoleic destructive of the oil offers a hint of natural gradation of solidarity. Fatty esters are increasing expanding significance as a biodegradable swap for mineral oils. In some request regions, for example, cutting tool oil, gearbox, pressure-driven oils, and greases for raw petroleum creation, the oleochemical items are set up. Nonetheless, certain particular wellsprings of fatty esters are hitherto to be abused for this comparative reason. This exploration subsequently tests into one of the less used wellsprings of fatty esters in watermelon. The oil from the kernels demonstrations a top-notch yield presents significant utilitarian gatherings for change and thus was utilized to set up an assortment of oleochemicals which demonstrated excellence materials in contrast with the routinely utilized oils feed frameworks for oleochemicals after portrayal. The photopolymers acquired indicated piercing vinyl protons for consistent polymerize.

Identification and characterization of marine based compounds for cancer treatment

Since antiquated occasions, nature has been a significant wellspring of medication: a reality outlined by the vast number of the characteristic items as of now utilized in clinical practice. Some of them have pharmacological movement because of their particular cooperations with receptors and chemicals. Since these substances become weakened by vast volumes of seawater, they need to be profoundly intense on a molar premise and need to hold a moderately low dissolvability. These items have been recognized and created through fables information on the vital possessions of plants, creature concentrates and minerals. Throughout the most recent couple of decades, noteworthy endeavours have been made, by both the drug organizations and the scholarly establishments, to disconnect and distinguish new marine inferred characteristic items. There are various specialized cycles associated with the assortment and distinguishing proof of the marine items with the potential enemy of tumour properties. Microorganisms are likewise a productive wellspring of novel operators. They have produced the absolute most significant drug items, for example, anti-microbials, penicillin and aminoglycosides, which speak to tourist spots throughout the entire existence of medication. Practically 60% of the medications affirmed for malignant growth are of the regular root. Vincristine, irinotecan, etoposide, taxanes and camptothecins are all plant determined mixes. Anthracyclins are of microbial inception. This paper presents a survey on how the marine and amphibian condition can be utilized for the advancement of anticancer medications.

Impact of organic farming in the pharmaceutical industry

Natural cultivating is types of unindustrialized that be contingent on strategy, for example, crop turn, green excrement, fertilizer and organic bug control. Depending upon whose characterization is exploited manure and insecticides (which incorporates herbicides bug sprays and fungicides) on the off chance that they are watched, as usual, Homology demonstrating, otherwise referred to as comparable displaying of protein which mentions to emerging a nuclear aim version of the "target" protein from its corrosive amino grouping and a three-dimensional test shape of an associated homologous protein (the "layout"). Natural humanizing work incongruity with fauna in its place of in contradiction of it. This comprises using approaches to complete excellent harvest yields without aching the shared environment or the individuals who animate and work in it. Scope of natural techniques can be utilized simultaneously to permit them to collaborate for the most dangerous benefit. For occurrence, the application of green nourishments and cautious expansion composed give favoured regulator of weeds over if the strategies were exploited all alone. Natural cultivating gives long haul advantages to individuals and the earth. Numerous research found that therapeutic plants developed naturally could improve good mixes. Examination to gather GAP (Good Agricultural Practices) for rejuvenating plants developed naturally in Indonesia should be urged to help the economical flexibly and effective of crude materials.

Review on nanobodies and its application in health sector

Today, bio-clinical endeavours are incoming the subcellular level, which is seen with the quick creating grounds of nanomedicine, nanodiagnostics and nano therapy related to the execution of nanoparticles for ailment counteraction, analysis, treatment and development. Nanoparticles or nanocontainers offer favourable circumstances counting high affectability, lower poisonousness and enhanced security—attributes that are exceptionally esteemed in the oncology field. Malignant growth cells create and multiply in complex microenvironments prompting heterogeneous infections, regularly with a deadly result for the patient. Even though counteracting agent-based treatment is generally utilized in the clinical consideration of patients with muscular tumours, its productivity certainly needs improvement. Restrictions of antibodies result for the most part from their colossal size and helpless entrance in healthy tissues. Nanobodies are a novel and unique class of antigen-restricting parts, gotten from naturally happening substantial chain-just antibodies present in the serum of camelids. Their boss properties, for example, small size, high soundness, solid antigen-restricting partiality, water solvency and common starting point make them reasonable for advancement into cutting edge bio drugs. Under 30 years after the disclosure of useful hefty chain-just antibodies, the nanobody subordinates are as of now broadly utilized by the biotechnology research network. Also, various nanobodies are under clinical examination for a wide range of human sicknesses including irritation, bosom malignancy, cerebrum tumours, lung maladies and irresistible ailments.

Application of carbon nanotubes targeting against infectious diseases

Carbon nanotubes can address the difficulties of fighting irresistible specialists by both limiting poisonousness by portion decrease of standard therapeutics and permitting a different payload ability to accomplish both focused on action and battling irresistible strains, safe strains precisely. One of their one of a kind attributes is the system of carbon particles in the nanometer scale, permitting the formation of nano-channels utilizing cell films. This audit centres around the portrayal, improvement, mix and utilization of carbon nanotubes as nano carrier-based conveyance frameworks and their fitting plan for accomplishing the ideal medication conveyance brings about the various zones of irresistible infections. While a more broad toxicological and pharmacological profile must be acquired, this audit will concentrate on existing examination and preclinical information concerning the likely utilization of carbon nanotubes. Because of their surprising possessions, carbon nanotubes have been widely utilized in hardware, optics and nanotechnology, among others. All the more as of late, they have additionally been utilized as vehicles for medication and antigen conveyance, the last being an original vaccination procedure in contradiction of irresistible infections and malignant growth. Here we talk about the capability of carbon nanotubes as an antigen conveyance device and propose additional headings in the ground of inoculation.